Natural history of liver fibrosis progression in patients with chronic hepatitis C
Abstract
Background Our aim was to assess the natural history of liver fibrosis progression in hepatitis C and the factors associated with this progression. Methods We recruited 2235 patients from the Observatoire de l'Hépatite C (OBSVIRC) population, the Cohorte Hépatite C Pitié-Salpétrière (DOSVIRC) population, and the original METAVIR population. All the patients had a biopsy sample compatible with chronic hepatitis C as assessed by the METAVIR scoring system (grades the stage of fibrosis on a five-point scale, F0 = no fibrosis, F4 = cirrhosis, and histological activity on a four-point scale, A0 = no activity, A3 = severe activity). No patient had received interferon treatment before the liver biopsy sample was obtained. We assessed the effect of nine factors on fibrosis progression: age at biopsy; estimated duration of infection; sex; age at infection; alcohol consumption; hepatitis C virus C (HCV) genotype; HCV viraemia; cause of infection; and histological activity grade. We defined fibrosis progression per year as the ratio between fibrosis stage in METAVIR units and the duration of infection (1 unit = one stage, 4 units = cirrhosis). Findings The median rate of fibrosis progression per year was 0.133 fibrosis unit (95% CI 0.125-0.143), which was similar to the estimates from previous studies (0.146 to 0.154). Three independent factors were associated with an increased rate of fibrosis progression: age at infection older than 40 years, daily alcohol consumption of 50 g or more, and male sex. There was no association between fibrosis progression and HCV genotype. The median estimated duration of infection for progression to cirrhosis was 30 years (28-32), ranging from 13 years in men infected after the age of 40 to 42 years in women who did not drink alcohol and were infected before the age of 40. Without treatment, 377 (33%) patients had an expected median time to cirrhosis of less than 20 years, and 356 (31%) will never progress to cirrhosis or will not progress for at least 50 years. Interpretation The host factors of ageing, alcohol consumption, and male sex have a stronger association with fibrosis progression than virological factors in HCV infection.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In patients with chronic liver disease, the rate of fibrosis progression varies widely, ranging from 10 to 50 years until cirrhosis develops.
“It is well known that individual patients with virtually any chronic liver disease demonstrate significant differences in the rate of fibrosis progression, ranging widely from 10 to 50 years until cirrhosis develops1.”
From Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis (2020) · cites this paper as [1]
Cites
An Algorithm for the Grading of Activity in Chronic Hepatitis C
Bédossa, P., & Poynard, T. (1996) · Hepatology · doi:10.1002/hep.510240201 · Cited by 4,054 · see citing works
Self-citationClassification of chronic hepatitis: Diagnosis, grading and staging
Desmet, V. J., Gerber, M. A., Hoofnagle, J. H., Manns, M. P., & Scheuer, P. J. (1994) · Hepatology · doi:10.1002/hep.1840190629 · Cited by 2,591 · see citing works
Bédossa, P. (1994) · Hepatology · doi:10.1002/hep.1840200104 · Cited by 2,189 · see citing works
Kiyosawa, K., Sodeyama, T., Tanaka, E., Gibo, Y., Yoshizawa, K., Nakano, Y., Furuta, S., Akahane, Y., Nishioka, K., Purcell, R. H., et al. (1990) · Hepatology · doi:10.1002/hep.1840120409 · Cited by 1,217 · see citing works
Clinical Outcomes after Transfusion-Associated Hepatitis C
Tong, M. J., El-Farra, N. S., Reikes, A., & Co, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506013322202 · Cited by 1,193 · see citing works
Poynard, T., Leroy, V., Cohard, M., Thévenot, T., Mathurin, P., Opolon, P., & Zarski, J. (1996) · Hepatology · doi:10.1002/hep.510240405 · Cited by 670 · see citing works
Self-citationThe Long–Term Pathological Evolution of Chronic Hepatitis C
Yano, M., Kumada, H., Kage, M., Ikeda, K., Shimamatsu, K., INOUE, O., Hashimoto, E., Lefkowitch, J. H., Ludwig, J., & Okuda, K. (1996) · Hepatology · doi:10.1002/hep.510230607 · Cited by 598 · see citing works
Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis
Bisceglie, A. M. D., Goodman, Z. D., Ishak, K. G., Hoofnagle, J. H., Melpolder, J. J., & Alter, H. J. (1991) · Hepatology · doi:10.1002/hep.1840140603 · Cited by 538 · see citing works
Epidemiology of Hepatitis C in the West
Alter, M. J. (1995) · Seminars in Liver Disease · doi:10.1055/s-2007-1007259 · Cited by 482 · see citing works
Poynard, T., Bédossa, P., Chevallier, M., Mathurin, P., Lemonnier, C., TREPO, C. G., Couzigou, P., Payen, J. L., Sajus, M., Costa, J. M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506013322201 · Cited by 454 · see citing works
Self-citationLong-term follow-up of non-A, non-B (type C) post-transfusion hepatitis
Tremolada, F., Casarin, C., Alberti, A., Drago, C., TAGGER, A., Ribero, M. L., & Realdi, G. (1992) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80657-9 · Cited by 263 · see citing works
The natural course of chronic hepatitis C
Iwarson, S. A. (1994) · FEMS Microbiology Reviews · doi:10.1016/0168-6445(94)90033-7 · Cited by 204 · see citing works
Kobayashi, M. (1996) · Hepatology · doi:10.1053/jhep.1996.v23.pm0008666319 · Cited by 189 · see citing works
The nomenclature of chronic active hepatitis: An obituary
Ludwig, J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90037-d · Cited by 187 · see citing works
Treatment of chronic type B and C hepatitis with interferon alfa: An economic appraisal
Dusheiko, G. M., & Roberts, J. A. (1995) · Hepatology · doi:10.1002/hep.1840220636 · Cited by 132 · see citing works
Natural course of chronic hepatitis C.
Takahashi, M., Yamada, G., Miyamoto, R., Doi, T., Endo, H., & Tsuji, T. (1993) · PubMed · Cited by 123 · see citing works
Sáez-Royuela, F., Porres, J. C., Moreno, A., Castillo, I., Martınez, G., Galiana, F., & Carréño, V. (1991) · Hepatology · doi:10.1002/hep.1840130220 · Cited by 104 · see citing works
Randomised trial of lymphoblastoid α-interferon in chronic hepatitis C
Camps, J., Castilla, A., Ruiz, J., Civeira, M. P., & Prìeto, J. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80223-5 · Cited by 82 · see citing works
Sáez-Royuela, F. (1991) · Hepatology · doi:10.1016/0270-9139(91)92448-h · Cited by 74 · see citing works
Rubio, M. G., Porres, J. C., Castillo, I., Quiroga, J. A., Moreno, A., & Carreno, V. (1990) · Journal of Hepatology · doi:10.1016/0168-8278(90)90166-o · Cited by 72 · see citing works
Blood-Borne Non-A, Non-B Hepatitis: Hepatitis C
Genescà, J., Esteban, J. I., & Alter, H. J. (1991) · Seminars in Liver Disease · doi:10.1055/s-2008-1040432 · Cited by 68 · see citing works
Hispathology of chronic hepatitis C in relation to epidemiological factors
Delladetsima, J. K., Rassidakis, G. Z., Tassoppoulos, N. C., Papatheodoridis, G., Smyrnoff, T., & Vafiadis, I. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80182-6 · Cited by 60 · see citing works
Presentation of hepatitis C in a unique uniform cohort 17 years from inoculation
Crowe, S. F., Doyle, C., Fielding, J. F., Holloway, H., Keegan, M., Kelleher, D. P., Kelly, P., Leader, M., Little, M. A., McDonald, G. S. A., et al. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)28518-0 · Cited by 26 · see citing works
Koff, R. S., & Seeff, L. B. (1995) · Hepatology · doi:10.1002/hep.1840220638 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Lauer, G. M., & Walker, B. D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107053450107 · Cited by 3,010 · see citing works
Diagnosis, management, and treatment of hepatitis C: An update # † ‡
Ghany, M. G., Strader, D. B., Thomas, D. L., & Seeff, L. B. (2008) · Hepatology · doi:10.1002/hep.22759 · Cited by 2,971 · see citing works
Global epidemiology of hepatitis C virus infection
Shepard, C. W., Finelli, L., & Alter, M. J. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70216-4 · Cited by 2,758 · see citing works
Sampling Variability of Liver Fibrosis in Chronic Hepatitis C
Bédossa, P., Dargère, D., & Paradis, V. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.022 · Cited by 2,370 · see citing works
Poynard, T., Marcellin, P., Lee, S. S., Niederau, C., Minuk, G., Ideo, G., Bain, V. G., Heathcote, J., Zeuzem, S., TREPO, C. G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)07124-4 · Cited by 2,310 · see citing works
Self-citationSchuppan, D., & Afdhal, N. H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60383-9 · Cited by 2,089 · see citing works
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780 · see citing works
Lai, C., Ratziu, V., Yuen, M., & Poynard, T. (2003) · The Lancet · doi:10.1016/s0140-6736(03)15108-2 · Cited by 1,724 · see citing works
Self-citationDiagnosis, management, and treatment of hepatitis C†
Strader, D. B., Wright, T. L., Thomas, D. L., & Seeff, L. B. (2004) · Hepatology · doi:10.1002/hep.20119 · Cited by 1,705 · see citing works
Imamura, H., Matsuyama, Y., Tanaka, E., Ohkubo, T., Hasegawa, K., Miyagawa, S., Sugawara, Y., Minagawa, M., Takayama, T., Kawasaki, S., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00360-4 · Cited by 1,592 · see citing works
Natural history of chronic hepatitis C
Seeff, L. B. (2002) · Hepatology · doi:10.1053/jhep.2002.36806 · Cited by 1,535 · see citing works
Imbert‐Bismut, F., Ratziu, V., Piéroni, L., Charlotte, F., Benhamou, Y., & Poynard, T. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04258-6 · Cited by 1,422 · see citing works
Self-citationPanel, A. I. H. G. (2015) · Hepatology · doi:10.1002/hep.27950 · Cited by 1,385 · see citing works
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Benhamou, Y., Bochet, M., Martino, V. D., Charlotte, F., Azria, F., Coutellier, A., Vidaud, M., Bricaire, F., Opolon, P., Katlama, C., et al. (1999) · Hepatology · doi:10.1002/hep.510300409 · Cited by 1,218 · see citing works
Self-citationPoynard, T., McHutchison, J. G., Manns, M. P., TREPO, C. G., Lindsay, K. L., Goodman, Z. D., Ling, M.-H., & Albrecht, J. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.33023 · Cited by 1,141 · see citing works
Self-citationIdentification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
Forns, X., Ampurdanés, S., Llovet, J. M., Aponte, J. Á. N., Quintó, L., Martínez‐Bauer, E., Bruguera, M., Sánchez-Tapias, J. M., & Rodés, J. (2002) · Hepatology · doi:10.1053/jhep.2002.36128 · Cited by 1,123 · see citing works
Yoshida, H., Shiratori, Y., Moriyama, M., Arakawa, Y., Ide, T., Sata, M., INOUE, O., Yano, M., Tanaka, M., Fujiyama, S., et al. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-3-199908030-00003 · Cited by 1,096 · see citing works
Gender differences in autoimmune disease
Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074 · see citing works
Adinolfi, L. E., Gambardella, M., Andreana, A., Tripodi, M., Utili, R., & Ruggiero, G. (2001) · Hepatology · doi:10.1053/jhep.2001.24432 · Cited by 1,052 · see citing works
Epidemiology and natural history of HCV infection
Hajarizadeh, B., Grebely, J., & Dore, G. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.107 · Cited by 994 · see citing works
Graham, C. S., Baden, L. R., Yu, E., Mrus, J. M., Carnie, J., Heeren, T., & Koziel, M. J. (2001) · Clinical Infectious Diseases · doi:10.1086/321909 · Cited by 973 · see citing works
Bica, I., McGovern, B. G., Dhar, R., Stone, D., McGowan, K., Scheib, R. G., & Snydman, D. R. (2001) · Clinical Infectious Diseases · doi:10.1086/318501 · Cited by 970 · see citing works
Ghany, M. G., Morgan, T. R. M., & Panel, A. H. C. G. (2019) · Hepatology · doi:10.1002/hep.31060 · Cited by 956 · see citing works
Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin
Kenny-Walsh, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904223401602 · Cited by 911 · see citing works
Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C
Liang, T. J., Rehermann, B., Seeff, L. B., & Hoofnagle, J. H. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-4-200002150-00008 · Cited by 868 · see citing works
The Natural History of Hepatitis C Virus (HCV) Infection
Chen, S. L., & Morgan, T. R. M. (2006) · International Journal of Medical Sciences · doi:10.7150/ijms.3.47 · Cited by 868 · see citing works
Colloredo, G., Guido, M., Sonzogni, A., & Leandro, G. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00191-0 · Cited by 866 · see citing works
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease†
Kim, W. R., Flamm, S. L., Bisceglie, A. M. D., & Bodenheimer, H. C. (2008) · Hepatology · doi:10.1002/hep.22109 · Cited by 858 · see citing works
ACG Clinical Guideline: Alcoholic Liver Disease
Singal, A. K., Bataller, R. A., Ahn, J. C., Kamath, P. S., & Shah, V. H. (2018) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.469 · Cited by 834 · see citing works
Estimation of stage‐specific fibrosis progression rates in chronic hepatitis C virus infection
Thein, H., Yi, Q., Dore, G. J., & Krahn, M. D. (2008) · Hepatology · doi:10.1002/hep.22375 · Cited by 828 · see citing works
Poynard, T., Yuen, M., Ratzin, V., & Lai, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)15109-4 · Cited by 806 · see citing works
Self-citationTreatment of Acute Hepatitis C with Interferon Alfa-2b
Jaeckel, E., Cornberg, M., Wedemeyer, H. H., Santantonio, T. A., Mayer, J. H., Zankel, M., Pastore, G., Dietrich, M., Trautwein, C., & Manns, M. P. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011232 · Cited by 794 · see citing works
Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c
Poynard, T., Ratziu, V., Charlotte, F., Goodman, Z., McHutchison, J., & Albrecht, J. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00097-0 · Cited by 749 · see citing works
Self-citationHCV-related fibrosis progression following liver transplantation: increase in recent years
Berenguer, M., Ferrell, L. D., Watson, J. J., Prieto, M., Kim, M., Rayón, M., Córdoba, J., García‐Herola, A., Ascher, N. L., Mir, J., et al. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80231-7 · Cited by 747 · see citing works
Alter, H. J., & Seeff, L. B. (2000) · Seminars in Liver Disease · doi:10.1055/s-2000-9505 · Cited by 734 · see citing works
Shiratori, Y., Imazeki, F., Moriyama, M., Yano, M., Arakawa, Y., Yokosuka, O., Kuroki, T., Nishiguchi, S., Sata, M., Yamada, G., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-7-200004040-00002 · Cited by 732 · see citing works
Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
Anstee, Q. M., & Goldin, R. D. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00465.x · Cited by 714 · see citing works
Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression
Hui, J. M., Sud, A., Farrell, G. C., Bandara, P., Byth, K., Kench, J. G., McCaughan, G. W., & George, J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.032 · Cited by 717 · see citing works
Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis
Gomaa, A. I., Khan, S. A., Toledano, M. B., Waked, I. A., & Taylor-Robinson, S. D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4300 · Cited by 692 · see citing works
Fibrosis in Chronic Hepatitis C Correlates Significantly With Body Mass Index and Steatosis
Hourigan, L. F., Macdonald, G. A., Purdie, D. M., Whitehall, V., Shorthouse, C., Clouston, A. D., & Powell, E. E. (1999) · Hepatology · doi:10.1002/hep.510290401 · Cited by 673 · see citing works
Donato, F. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.4.323 · Cited by 672 · see citing works
Non-invasive assessment of hepatic iron stores by MRI
Gandon, Y., Olivié, D., Guyader, D., Aubé, C., Oberti, F., Sebille, V., & Deugnier, Y. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15436-6 · Cited by 668 · see citing works
Pincus, T., Swearingen, C. J., & Wolfe, F. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199910)42:10 · Cited by 403 · see citing works
Self-citationEpidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Massarweh, N. N., & El‐Serag, H. B. (2017) · Cancer Control · doi:10.1177/1073274817729245 · Cited by 637 · see citing works
El‐Serag, H. B. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200211002-00002 · Cited by 633 · see citing works
Prognosis of Chronic Hepatitis C: Results of A Large, Prospective Cohort Study
Niederau, C., Lange, S., Heintges, T., Erhardt, A., Buschkamp, M., Hürter, D., Nawrocki, M., Kruska, L., Hensel, F., Petry, W., et al. (1998) · Hepatology · doi:10.1002/hep.510280632 · Cited by 632 · see citing works
Estimating progression to cirrhosis in chronic hepatitis C virus infection
Freeman, A. J., Dore, G. J., Law, M. G., Thorpe, M. E. C., von Overbeck, J., Lloyd, A. R., Marinos, G., & Kaldor, J. M. (2001) · Hepatology · doi:10.1053/jhep.2001.27831 · Cited by 620 · see citing works
Berenguer, M., Prieto, M., Juan, F. S., Rayón, J. M., Martinez, F., Carrasco, D., Moya, A., Orbís, F., Mir, J., & Berenguer, J. (2002) · Hepatology · doi:10.1053/jhep.2002.33993 · Cited by 599 · see citing works
Estimating future hepatitis C morbidity, mortality, and costs in the United States
Wong, J. B., McQuillan, G. M., McHutchison, J. G., & Poynard, T. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.10.1562 · Cited by 566 · see citing works
Self-citationLeandro, G., Mangia, A., Hui, J. M., Fabris, P., Rubbia‐Brandt, L., Colloredo, G., Adinolfi, L. E., Asselah, T., Jonsson, J. R., Smedile, A., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.014 · Cited by 562 · see citing works
Now there are many (stages) where before there was one
García–Tsao, G., Friedman, S. L., Iredale, J. P., & Pinzani, M. (2009) · Hepatology · doi:10.1002/hep.23478 · Cited by 539 · see citing works
Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection
Adams, L. A., Bulsara, M. K., Rossi, E., DeBoer, B., Speers, D. J., George, J., Kench, J. G., Farrell, G. C., McCaughan, G. W., & Jeffrey, G. P. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.048389 · Cited by 536 · see citing works
Impact of Hepatitis B and C Virus on Kidney Transplantation Outcome
Mathurin, P., Mouquet, C., Poynard, T., Sylla, C., Benalia, H., Fretz, C., Thibault, V., Cadranel, J., Bernard‐Chabert, B., Opolon, P., et al. (1999) · Hepatology · doi:10.1002/hep.510290123 · Cited by 531 · see citing works
Self-citationKim, I. H., Kisseleva, T., & Brenner, D. A. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000176 · Cited by 499 · see citing works
Darby, S. C., Ewart, D. W., Giangrande, P. L. F., Spooner, R. J. D., Rizza, C. R., Dusheiko, G. M., Lee, C. A., Ludlam, C. A., & Preston, F. E. (1997) · The Lancet · doi:10.1016/s0140-6736(97)05413-5 · Cited by 496 · see citing works
Rosen, H. R. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp1006613 · Cited by 487 · see citing works
Chronic hepatitis C virus (HCV) disease burden and cost in the United States
Razavi, H., ElKhoury, A. C., Elbasha, E., Estes, C., Pasini, K., Poynard, T., & Kumar, R. (2013) · Hepatology · doi:10.1002/hep.26218 · Cited by 474 · see citing works
Self-citationSteatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
Lonardo, A., Adinolfi, L. E., Loria, P., Carulli, N., Ruggiero, G., & Day, C. P. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.020 · Cited by 476 · see citing works
A comparison of fibrosis progression in chronic liver diseases
Poynard, T., Mathurin, P., Lai, C., Guyader, D., Poupon, R. E., Tainturier, M.-H., Myers, R. P., Muntenau, M., Ratziu, V., Manns, M. P., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00413-0 · Cited by 472 · see citing works
Self-citationNatural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
Fassio, E., �lvarez, E., Dom�nguez, N., Landeira, G., & Longo, C. (2004) · Hepatology · doi:10.1002/hep.20410 · Cited by 470 · see citing works
Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
Ratziu, V., Bonyhay, L., Martino, V. D., Charlotte, F., Cavallaro, L. G., Sayegh-Tainturier, M.-H., Giral, P., Grimaldi, A., Opolon, P., & Poynard, T. (2002) · Hepatology · doi:10.1053/jhep.2002.33324 · Cited by 461 · see citing works
Self-citationElastic modulus measurements of human liver and correlation with pathology
Yeh, W., Li, P., Jeng, Y., Hsu, H., Kuo, P.-L., Li, M., Yang, P., & Lee, P. (2002) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(02)00489-1 · Cited by 459 · see citing works
MR Elastography of the Liver: Preliminary Results
Rouvière, O., Yin, M., Dresner, M. A., Rossman, P. J., Burgart, L. J., Fidler, J. L., & Ehman, R. L. (2006) · Radiology · doi:10.1148/radiol.2402050606 · Cited by 446 · see citing works
Influence of Human Immunodeficiency Virus Infection on Chronic Hepatitis B in Homosexual Men
Colin, J., Cazals-Hatem, D. L., Loriot, M., Martinot-Peignoux, M., Pham, B. N., Auperin, A., Degott, C., Benhamou, J., Erlinger, S., Valla, D. C., et al. (1999) · Hepatology · doi:10.1002/hep.510290447 · Cited by 444 · see citing works
Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors
Schütte, K., Bornschein, J., & Malfertheiner, P. (2009) · Digestive Diseases · doi:10.1159/000218339 · Cited by 441 · see citing works
Dufour, D. R., Lott, J. A., Nolte, F. S., Gretch, D. R., Koff, R. S., & Seeff, L. B. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.12.2050 · Cited by 439 · see citing works
Long–Term Outcomes of Cirrhosis in Nonalcoholic Steatohepatitis Compared With Hepatitis C
Hui, J. M., Kench, J. G., Chitturi, S., Sud, A., Farrell, G. C., Byth, K., Hall, P. D. L. Μ., Khan, M., & George, J. (2003) · Hepatology · doi:10.1053/jhep.2003.50320 · Cited by 436 · see citing works
Webster, D. P., Klenerman, P., & Dusheiko, G. M. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62401-6 · Cited by 436 · see citing works
An appraisal of the histopathological assessment of liver fibrosis
Standish, R. A., Cholongitas, Ε., Dhillon, A. P., Burroughs, A. K., & Dhillon, A. P. (2006) · Gut · doi:10.1136/gut.2005.084475 · Cited by 428 · see citing works
Benhamou, Y., Martino, V. D., Bochet, M., Colombet, G., Thibault, V., Liou, A., Katlama, C., & Poynard, T. (2001) · Hepatology · doi:10.1053/jhep.2001.26517 · Cited by 422 · see citing works
Self-citationRisk Factors for the Rising Rates of Primary Liver Cancer in the United States
El‐Serag, H. B., & Mason, A. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3227 · Cited by 418 · see citing works
Natural history of hepatitis C
Seeff, L. B. (1997) · Hepatology · doi:10.1002/hep.510260704 · Cited by 414 · see citing works
DeLeve, L. D., Wang, X., & Guo, Y. (2008) · Hepatology · doi:10.1002/hep.22351 · Cited by 408 · see citing works
Thein, H., Yi, Q., Dore, G. J., & Krahn, M. D. (2008) · AIDS · doi:10.1097/qad.0b013e32830e6d51 · Cited by 408 · see citing works
Hepatitis C in the HIV-Infected Person
Sulkowski, M. S., & Thomas, D. L. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-3-200302040-00012 · Cited by 405 · see citing works
Progression of fibrosis in chronic hepatitis C
Ghany, M. G., Kleiner, D. E., Alter, H. J., Doo, E. C., Khokar, F., Promrat, K., Herion, D. W., Park, Y., Liang, T. J., & Hoofnagle, J. H. (2003) · Gastroenterology · doi:10.1053/gast.2003.50018 · Cited by 402 · see citing works
Natural History of Hepatitis C
Thomas, D. L., & Seeff, L. B. (2005) · Clinics in Liver Disease · doi:10.1016/j.cld.2005.05.003 · Cited by 401 · see citing works
Fibrosis and disease progression in hepatitis C
Marcellin, P., Asselah, T., & Boyer, N. (2002) · Hepatology · doi:10.1053/jhep.2002.36993 · Cited by 398 · see citing works
Host genetic factors influence disease progression in chronic hepatitis C
Powell, E. E., Edwards-Smith, C. J., Hay, J. L., Clouston, A. D., Crawford, D. H., Shorthouse, C., Purdie, D. M., & Jonsson, J. R. (2000) · Hepatology · doi:10.1053/he.2000.6253 · Cited by 397 · see citing works
American Gastroenterological Association Technical Review on the Management of Hepatitis C
Dienstag, J. L., & McHutchison, J. G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.010 · Cited by 382 · see citing works
Global epidemiology and burden of HCV infection and HCV-related disease
Thrift, A. P., El‐Serag, H. B., & Kanwal, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.176 · Cited by 382 · see citing works
Ikeda, M., Yi, M., Li, K., & Lemon, S. M. (2002) · Journal of Virology · doi:10.1128/jvi.76.6.2997-3006.2002 · Cited by 381 · see citing works
Reversal of Hepatic Fibrosis — Fact or Fantasy?
Friedman, S. L., & Bansal, M. B. (2006) · Hepatology · doi:10.1002/hep.20974 · Cited by 377 · see citing works
The role of liver biopsy in chronic hepatitis C
Dienstag, J. L. (2002) · Hepatology · doi:10.1002/hep.1840360720 · Cited by 377 · see citing works
The evolving epidemiology of hepatocellular carcinoma: a global perspective
Wallace, M. C., Preen, D. B., Jeffrey, G. P., & Adams, L. A. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1028363 · Cited by 374 · see citing works
Epidemiology and natural history of hepatocellular carcinoma
McGlynn, K. A., & London, W. T. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.10.004 · Cited by 373 · see citing works
Natural history of hepatitis C
Alberti, A., Chemello, L., & Benvegnù, L. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80369-9 · Cited by 366 · see citing works
Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol
Monto, A., Alonzo, J., Watson, J. J., Grünfeld, C., & Wright, T. L. (2002) · Hepatology · doi:10.1053/jhep.2002.35064 · Cited by 360 · see citing works
Bräu, N., Salvatore, M., Ríos‐Bedoya, C. F., Fernández-Carbia, A., Paronetto, F., Rodríguez‐Orengo, J. F., & Rodriguez‐Torres, M. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.07.006 · Cited by 359 · see citing works
Genetic Polymorphisms and the Progression of Liver Fibrosis: A Critical Appraisal
Bataller, R. A., North, K. E., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50127 · Cited by 354 · see citing works
Féray, C., Caccamo, L., Alexander, G., Ducot, B., Gugenheim, J., Casanovas, T., Loinaz, C., Gigou, M., Burra, P., Barkholt, L., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70454-3 · Cited by 353 · see citing works
International trends and patterns of primary liver cancer
McGlynn, K. A., Tsao, L., Hsing, A. W., Devesa, S. S., & Fraumeni, J. F. (2001) · International Journal of Cancer · doi:10.1002/ijc.1456 · Cited by 350 · see citing works
Wiese, M., Berr, F., Lafrenz, M., Porst, H., & Oesen, U. (2000) · Hepatology · doi:10.1053/jhep.2000.8169 · Cited by 349 · see citing works
Noninvasive Measures of Liver Fibrosis
Rockey, D. C., & Bissell, M. D. (2006) · Hepatology · doi:10.1002/hep.21046 · Cited by 348 · see citing works
45-Year Follow-up of Hepatitis C Virus Infection in Healthy Young Adults
Seeff, L. B., Miller, R. N., Rabkin, C. S., Buskell‐Bales, Z., Straley-Eason, K. D., Smoak, B. L., Johnson, L. D., Lee, S. R., & Kaplan, E. L. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-2-200001180-00003 · Cited by 348 · see citing works
Hepatic inflammation and progressive liver fibrosis in chronic liver disease
Czaja, A. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2515 · Cited by 354 · see citing works
Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
Li, D., & Friedman, S. L. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01928.x · Cited by 337 · see citing works
Wanless, I. R., Nakashima, E., & Sherman, M. (2000) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2000-124-1599-rohc · Cited by 340 · see citing works
- Authors
- Poynard, T., Bedossa, P., & Opolon, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Poynard, Thierry
- ORCID
- Poynard, Thierry
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 349
- Issue
- 9055
- Pages
- 825-832
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2132290252
- Cited by
- 3,011
- References
- 24
- Citations by year
- 2026: 16 · 2025: 35 · 2024: 33 · 2023: 38 · 2022: 43 · 2021: 45 · 2020: 71 · 2019: 74 · 2018: 72 · 2017: 90 · 2016: 117 · 2015: 141 · 2014: 120 · 2013: 138 · 2012: 114
- FWCI
- 60.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Assistance Publique - Hôpitaux de Paris
- Assistance publique-Hôpitaux de Paris
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- chronic hepatitis C, liver fibrosis progression, natural history (disease), METAVIR scoring, liver cirrhosis, age at infection, alcohol consumption, sex differences, HCV genotypes, HCV viraemia, host factors, infection duration, histological activity, liver biopsy
- MeSH terms
- Adult, Age Factors, Alcohol Drinking, Biopsy, Cross-Sectional Studies, Female, Hepatitis, Chronic, Hepatitis C, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Risk Factors, Sex Factors, Time Factors, Prevalence, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
