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Miconazole, a Broad-Spectrum Antimycotic Agent with Antibacterial Activity
Abstract
Miconazole tested in vitro against the most important fungi pathogenic for man and animals, and against gram-positive bacteria has proved to be highly potent. The dermatophytes, yeasts, dimorphic fungi, Aspergilli and the mycetoma-causing agents are the most sensitive. This activity was confirmed by in vivo tests on guinea pigs infected with Trichophyton mentagrophytes, Microsporum canis or Candida albicans. Miconazole used orally or topically was very active against experimental tinea and candidosis in guinea pigs. For each test, the authors compared the activity of miconazole with different reference compounds.
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Citations
Cited by
Overview of medically important antifungal azole derivatives
Fromtling, R. A. (1988) · Clinical Microbiology Reviews · doi:10.1128/cmr.1.2.187 · Cited by 398
Strategies in the Treatment of Systemic Fungal Infections
Medoff, G., & Kobayashi, G. S. (1980) · New England Journal of Medicine · doi:10.1056/nejm198001173020304 · Cited by 342
Econazole: A Review of its Antifungal Activity and Therapeutic Efficacy
Heel, R. C., Brogden, R. N., Speight, T. M., & Avery, G. S. (1978) · Drugs · doi:10.2165/00003495-197816030-00001 · Cited by 296
Saputo, S., Faustoferri, R. C., & Quivey, R. G. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01674-17 · Cited by 29
Metadata
- Authors
- Van Cutsem, J. M., & Thienpont, D.
- Venue
- Chemotherapy
- Publisher
- S. Karger AG
- Published
- 1972
- Volume
- 17
- Issue
- 6
- Pages
- 392-404
- ISSN
- 0009-3157 (ISSN-L)
- 1421-9794
- OpenAlex
- W1967004337
- Cited by
- 263
- References
- 0
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Van Cutsem, J. M., & Thienpont, D. (1972). Miconazole, a Broad-Spectrum Antimycotic Agent with Antibacterial Activity. Chemotherapy. https://doi.org/10.1159/000220875
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
