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Osteoporosis after Stroke: A Review of the Causes and Potential Treatments
Open accessAbstract
Osteoporosis is a known consequence of stroke, associated with an increased incidence of fractures, mainly of the hip, leading to further disability. The pattern of bone loss seen in stroke patients is different from that usually encountered with postmenopausal osteoporosis, since it is limited to the paretic side and more evident in the upper extremities. Several factors appear to have an influence on bone mass in stroke patients, such as the degree of paresis, gait disability and the duration of immobilization. The pathogenesis of osteoporosis after stroke remains unclear. Paresis, reduced mobility and reduced bone load seem to play a major role. Other factors such as nutritional and iatrogenic ones may also play an important part. In this paper, the clinical evidence, pathophysiology and possible treatments of poststroke osteoporosis will be reviewed.
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Affected trial reports were included in three reviews where it was unclear if findings would be altered by the omission of the affected reports' data.
“Affected trial reports were included in three reviews (Alibhai et al 35 118 citations, October 2018; Carda et al 36 24 citations, September 2018; Simpson et al 37 14 citations, April 2018) where it was unclear if findings would be altered by the omission of the affected reports’ data.”
From An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature (2019) · cites this paper as [36]
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“…been cited 346 times, including September 2018, and it references four of the six above-mentioned affected trial reports, with these reports being the sole sources of data evidencing the reduction in fractures from bisphosphonates in patients with Parkinson’s disease, Alzheimer’s disease or stroke.”
Background
Metadata
- Authors
- Carda, S., Cisari, C., Invernizzi, M., & Bevilacqua, M.
- Affiliations
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Milan (IT)
- Venue
- Cerebrovascular Diseases
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 28
- Issue
- 2
- Pages
- 191-200
- ISSN
- 1015-9770 (ISSN-L)
- 1421-9786
- OpenAlex
- W2085742735
- Cited by
- 104
- References
- 87
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 12 · 2023: 6 · 2022: 13 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2009-06-30)
- Open access
- bronze
- doi.org
- Locations
- Cerebrovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- stroke, bone loss, hip fracture, paresis, immobilization, gait disability, bone mass, pathogenesis, osteoporosis treatment, dietary factors, iatrogenic factors
- MeSH terms
- Stroke Rehabilitation, Combined Modality Therapy, Female, Humans, Male, Osteoporosis, Risk Factors, Bone Density, Treatment Outcome, Risk Assessment, Stroke
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