Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe
Abstract
Background: Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to kisspeptin treatment varies between the breeding and nonbreeding seasons. Methods: Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 μg or maximal dose: 250 μg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle. Results: Kisspeptin treatment increased the concentration of luteinizing hormone (LH) in all animals. We found the LH response to kisspeptin (20 μg) was greater in ewes during the anestrous period, being 4-fold that seen during the luteal phase of the estrous cycle. Within the breeding season, kisspeptin (20 μg) was most effective during the late-follicular phase of the estrous cycle. Kisspeptin treatment (both 20 and 250 μg) had no effect on plasma levels of growth hormone, prolactin or cortisol. The variable effect of kisspeptin (20 μg) on LH secretion appeared to mirror that of GnRH treatment indicating that the effect may be mediated by a change in the pituitary response to GnRH. Conclusion: We conclude that the gonadotropic response to kisspeptin depends upon the reproductive status of the female.
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Kisspeptin has been reported not to affect circulating levels of PRL in adult rats, ewes, rhesus monkeys, or healthy women.
“Kisspeptin has been reported not to affect circulating levels of PRL in adult rats (38), ewes (39), rhesus monkeys (40), or healthy women (41).”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [39]
Cites
The <i>GPR54</i> Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557 · see citing works
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 1× · see citing works
“and are critical for the onset of puberty and normal reproductive function [”
BackgroundNavarro, V. M., Castellano, J. M., Fernández-Fernández, R., Tovar, S., Roa, J., Mayen, A., Nogueiras, R., Vazquez, M. J., Barreiro, M. L., Magni, P., et al. (2005) · Endocrinology · doi:10.1210/en.2004-0836 · Cited by 449 · see citing works
Smith, J. T., Clay, C. M., Caraty, A., & Clarke, I. J. (2007) · Endocrinology · doi:10.1210/en.2006-1435 · Cited by 404 · see citing works
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Chan, Y.-M., Butler, J. P., Sidhoum, V. F., Pinnell, N. E., & Seminara, S. B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1282 · Cited by 100 · see citing works
Kisspeptin regulates prolactin release through hypothalamic dopaminergic neurons
Szawka, R. E., Ribeiro, A. B., Leite, C. M., Helena, C. V. V., Franci, C. R., Anderson, G. M., Hoffman, G. E., & Anselmo-Franci, J. A. (2010) · Endocrinology · doi:10.1210/en.2009-1414 · Cited by 97 · see citing works
Smith, J. T. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2011.11.003 · Cited by 55 · see citing works
Self-citationKisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans
Hoskova, K., Kayton Bryant, N., Chen, M. E., Nachtigall, L. B., Lippincott, M. F., Balasubramanian, R., & Seminara, S. B. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac166 · Cited by 39 · see citing works
- Authors
- Smith, J. T., Saleh, S. N. H., & Clarke, I. J.
- Affiliations
- Monash University (AU)
- ORCID
- Clarke, Iain J.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 90
- Issue
- 3
- Pages
- 283-291
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2093706999
- Cited by
- 49
- References
- 4
- Citations by year
- 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 7
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- kisspeptin, luteinizing hormone, kisspeptin-10, gonadotropin-releasing hormone, anestrus, estrous cycle, seasonal reproduction, ewes, Corriedale sheep, reproductive status, follicular phase, luteal phase
- MeSH terms
- Anestrus, Animals, Female, Follicle Stimulating Hormone, Hydrocortisone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Oligopeptides, Periodicity, Prolactin, Radioimmunoassay, Seasons, Sheep, Growth Hormone, Estrous Cycle, Mice, Kisspeptins
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