KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season

Smith, Jeremy T.; Clay, Colin M.; Caraty, Alain; Clarke, Iain J.

doi:10.1210/en.2006-1435

Cited by 404Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season

Smith, Jeremy T., Clay, Colin M., Caraty, Alain, Clarke, Iain J.·2007·Endocrinology

DOI 10.1210/en.2006-1435

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Abstract

The KiSS-1 gene encodes a family of peptides called kisspeptins, which are endogenous ligands for the G protein-coupled receptor GPR54. Kisspeptin function appears to be critical for GnRH secretion and the initiation of puberty. To test the hypothesis that steroid hormones regulate KiSS-1 mRNA expression in the ewe, we examined the brains of ovary-intact (luteal phase) and ovariectomized (OVX) ewes, as well as OVX ewes that received estradiol (E) or progesterone (P) replacement. KiSS-1 mRNA-expressing cells were predominantly located in the arcuate nucleus (ARC). Here, expression was increased after OVX but returned to the level of gonad-intact animals with E treatment. Treatment with P partially restored KiSS-1 expression toward gonad-intact levels. Double-label immunohistochemistry revealed that approximately 86% of kisspeptin-immunoreactive cells in the ARC are also P-receptor positive. Finally, we tested the hypothesis that KiSS-1 mRNA is lower during anestrus, due to a non-steroid-dependent seasonal effect. In OVX ewes, expression in the ARC was lower at the time of year corresponding to anestrus. We conclude that KiSS-1 expression in the ARC of the ewe brain is negatively regulated by chronic levels of E and P, suggesting that both steroids may exert negative feedback control on GnRH secretion through altered kisspeptin signaling. Furthermore, a seasonal alteration in KiSS-1 expression in the ARC of OVX ewes strongly suggests that kisspeptin is fundamentally involved in the control of seasonal changes in reproductive function.

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In animal models, the KISS1 neurons appear to mediate sex steroid feedback effects in the hypothalamus.
“In animal models, the KISS1 neurons appear to mediate sex steroid feedback effects in the hypothalamus.58,59”
From Pubertal development and regulation (2016) · cites this paper as [59]

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Dynamics of gonadotropin-releasing hormone release during a pulse.
Moenter, S. M., Brand, R. M., MIDGLEY, A. R., & Karsch, F. J. (1992) · Endocrinology · doi:10.1210/endo.130.1.1727719 · Cited by 1,257 · see citing works
Kisspeptin Signaling in the Brain
Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0005 · Cited by 842 · see citing works
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 802 · see citing works
Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
Lehman, M. N., Coolen, L. M., & Goodman, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0022 · Cited by 768 · see citing works
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B
Goodman, R. L., Lehman, M. N., Smith, J. T., Coolen, L. M., de Oliveira, C. V. R., Jafarzadehshirazi, M. R., Pereira, A., Iqbal, J., Caraty, A., Ciofi, P., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0961 · Cited by 692 · see citing works
Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works
Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
Wakabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, V. M., Clifton, D. K., Mori, Y., Tsukamura, H., Maeda, K.-I., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5848-09.2010 · Cited by 597 · see citing works
Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge
Clarkson, J., d'Anglemont de Tassigny, X., Moreno, A. S., Colledge, W. H., & Herbison, A. E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1775-08.2008 · Cited by 436 · see citing works
Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
Rometo, A. M., Krajewski, S. J., Lou Voytko, M., & Rance, N. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0553 · Cited by 396 · see citing works
Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep
Smith, J. T., Coolen, L. M., Kriegsfeld, L. J., Sari, I. P., Jaafarzadehshirazi, M. R., Maltby, M., Bateman, K., Goodman, R. L., Tilbrook, A. J., Ubuka, T., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0581 · Cited by 387 · see citing works
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes
Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380 · see citing works
Hypothalamic pathways linking energy balance and reproduction
Hill, J. W., Elmquist, J. K., & Elias, C. F. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00670.2007 · Cited by 366 · see citing works
Characterization of Kiss1 neurons using transgenic mouse models
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J., Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.022 · Cited by 353 · see citing works
Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain
Clarkson, J., D’Anglemont de Tassigny, X., Colledge, W. H., Caraty, A., & Herbison, A. E. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01892.x · Cited by 346 · see citing works
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
Roa, J., Aguilar, E., Diéguez, C., Pinilla, L., & Tena‐Sempere, M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.002 · Cited by 343 · see citing works
Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes
Caraty, A., Smith, J. T., Lomet, D., Ben Saïd, S., Morrissey, A., Cognie, J., Doughton, B., Baril, G., Briant, C., & Clarke, I. J. (2007) · Endocrinology · doi:10.1210/en.2007-0554 · Cited by 313 · see citing works
The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep
Cheng, G., Coolen, L. M., Padmanabhan, V., Goodman, R. L., & Lehman, M. N. (2009) · Endocrinology · doi:10.1210/en.2009-0541 · Cited by 304 · see citing works
Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women
Dhillo, W. S., Chaudhri, O. B., Thompson, E. L., Murphy, K. G., Patterson, M., Ramachandran, R., Nijher, G. M. K., Amber, V., Kokkinos, A. D., Donaldson, M., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1116 · Cited by 293 · see citing works
Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells
Backholer, K., Smith, J. T., Rao, A. V. N., Pereira, A., Iqbal, J., Ogawa, S., Li, Q., & Clarke, I. J. (2010) · Endocrinology · doi:10.1210/en.2009-1190 · Cited by 289 · see citing works
Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy
Ramaswamy, S., Guerriero, K. A., Gibbs, R. B., & Plant, T. M. (2008) · Endocrinology · doi:10.1210/en.2008-0438 · Cited by 279 · see citing works
GnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259 · see citing works
Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence
Smith, J. T., Li, Q., Yap, K. S., Shahab, M., Roseweir, A. K., Millar, R. P., & Clarke, I. J. (2011) · Endocrinology · doi:10.1210/en.2010-1225 · Cited by 254 · see citing works
Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network
Herbison, A. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00011-9 · Cited by 255 · see citing works
The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction
Popa, S. M., Clifton, D. K., & Steiner, R. A. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100540 · Cited by 245 · see citing works
Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
Rance, N. E. (2009) · Peptides · doi:10.1016/j.peptides.2008.05.016 · Cited by 237 · see citing works
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Felip, A., Zanuy, S., Pineda, R., Pinilla, L., Carrillo, M., Tena‐Sempere, M., & Gómez, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.017 · Cited by 232 · see citing works
Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)
Kanda, S., Akazome, Y., Matsunaga, T., Yamamoto, N., Yamada, S., Tsukamura, H., Maeda, K., & Oka, Y. (2008) · Endocrinology · doi:10.1210/en.2007-1503 · Cited by 231 · see citing works
The role of kisspeptin in the control of gonadotrophin secretion
Roseweir, A. K., & Millar, R. P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn058 · Cited by 213 · see citing works
Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction
Kauffman, A. S., Clifton, D. K., & Steiner, R. A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.001 · Cited by 214 · see citing works
Kisspeptin Neurons in the Ovine Arcuate Nucleus and Preoptic Area Are Involved in the Preovulatory Luteinizing Hormone Surge
Smith, J. T., Li, Q., Pereira, A. Z., & Clarke, I. J. (2009) · Endocrinology · doi:10.1210/en.2009-0712 · Cited by 208 · see citing works
Tracking the seasons: the internal calendars of vertebrates
Paul, M. J., Zucker, I., & Schwartz, W. J. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2143 · Cited by 204 · see citing works
Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
Maeda, K., Ohkura, S., Uenoyama, Y., Wakabayashi, Y., Oka, Y., Tsukamura, H., & Okamura, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.026 · Cited by 192 · see citing works
Discovery and Evolutionary History of Gonadotrophin‐Inhibitory Hormone and Kisspeptin: New Key Neuropeptides Controlling Reproduction
Tsutsui, K., Bentley, G. E., Kriegsfeld, L. J., Osugi, T., Seong, J. Y., & Vaudry, H. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02018.x · Cited by 191 · see citing works
KNDy Cells Revisited
Moore, A. M., Coolen, L. M., Porter, D. T., Goodman, R. L., & Lehman, M. N. (2018) · Endocrinology · doi:10.1210/en.2018-00389 · Cited by 190 · see citing works
Neuroendocrine control by dopamine of teleost reproduction
Dufour, S., Sébert, M., Weltzien, F., Rousseau, K., & Pasqualini, C. (2010) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2009.02499.x · Cited by 184 · see citing works
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Billings, H. J., Connors, J. M., Altman, S., Hileman, S. M., Holásková, I., Lehman, M. N., McManus, C. J., Nestor, C. C., Jacobs, B. H., & Goodman, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0174 · Cited by 179 · see citing works
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects
Lehman, M. N., Hileman, S. M., & Goodman, R. L. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-6199-9_3 · Cited by 180 · see citing works
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat
Krajewski, S. J., Burke, M. C., Anderson, M. J., McMullen, N. T., & Rance, N. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.053 · Cited by 178 · see citing works
The Role of Kisspeptin Signaling in Reproduction
de Tassigny, X. D., & Colledge, W. H. (2010) · Physiology · doi:10.1152/physiol.00009.2010 · Cited by 174 · see citing works
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
Clarke, H., Dhillo, W. S., & Jayasena, C. N. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.2.124 · Cited by 175 · see citing works
Anatomy of the kisspeptin neural network in mammals
Lehman, M. N., Merkley, C. M., Coolen, L. M., & Goodman, R. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.020 · Cited by 172 · see citing works
Mammalian Seasonal Rhythms: Behavior and Neuroendocrine Substrates
Stevenson, T. J., Prendergast, B. J., & Nelson, R. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00013-4 · Cited by 169 · see citing works
Leptin and reproductive function
Hausman, G. J., Barb, C. R., & Lents, C. A. (2012) · Biochimie · doi:10.1016/j.biochi.2012.02.022 · Cited by 164 · see citing works
Oestrogen, Kisspeptin, GPR54 and the Pre‐Ovulatory Luteinising Hormone Surge
Clarkson, J., & Herbison, A. E. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01835.x · Cited by 159 · see citing works
Sex Steroids and the Control of the Kiss1 System: Developmental Roles and Major Regulatory Actions
García-Galiano, D., Pinilla, L., & Tena‐Sempere, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02230.x · Cited by 153 · see citing works
RFamide‐Related Peptide and its Cognate Receptor in the Sheep: cDNA Cloning, mRNA Distribution in the Hypothalamus and the Effect of Photoperiod
Dardente, H., Birnie, M. J., Lincoln, G. A., & Hazlerigg, D. G. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01784.x · Cited by 146 · see citing works
Guinea Pig Kisspeptin Neurons Are Depolarized by Leptin via Activation of TRPC Channels
Qiu, J., Fang, Y., Bosch, M. A., Rønnekleiv, O. K., & Kelly, M. J. (2011) · Endocrinology · doi:10.1210/en.2010-1285 · Cited by 146 · see citing works
KNDy (Kisspeptin/Neurokinin B/Dynorphin) Neurons Are Activated during Both Pulsatile and Surge Secretion of LH in the Ewe
Merkley, C. M., Porter, K. L., Coolen, L. M., Hileman, S. M., Billings, H. J., Drews, S., Goodman, R. L., & Lehman, M. N. (2012) · Endocrinology · doi:10.1210/en.2012-1357 · Cited by 138 · see citing works
Social Regulation of Gene Expression in the Hypothalamic-Pituitary-Gonadal Axis
Maruska, K. P., & Fernald, R. D. (2011) · Physiology · doi:10.1152/physiol.00032.2011 · Cited by 137 · see citing works
Hypothalamic Expression of KISS1 and Gonadotropin Inhibitory Hormone Genes During the Menstrual Cycle of a Non-Human Primate1
Smith, J. T., Shahab, M., Pereira, A., Pau, K. ‐. F., & Clarke, I. J. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.085407 · Cited by 137 · see citing works
Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe
Smith, J. T. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.002 · Cited by 132 · see citing works
Kisspeptin: A key link to seasonal breeding
Revel, F. G., Ansel-Bollepalli, L., Klosen, P., Saboureau, M., Pévet, P., Mikkelsen, J. D., & Simonneaux, V. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9031-7 · Cited by 131 · see citing works
Melatonin‐Dependent Timing of Seasonal Reproduction by the Pars Tuberalis: Pivotal Roles for Long Daylengths and Thyroid Hormones
Dardente, H. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02250.x · Cited by 128 · see citing works
Molecular Characterization and Estrogen Regulation of Hypothalamic KISS1 Gene in the Pig1
Tomikawa, J., Homma, T., Tajima, S., Shibata, T., Inamoto, Y., Takase, K., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.079863 · Cited by 126 · see citing works
Kisspeptin and energy balance in reproduction
Bond, J. P. D., & Smith, J. T. (2013) · Reproduction · doi:10.1530/rep-13-0509 · Cited by 126 · see citing works
A simple model of estrous cycle negative and positive feedback regulation of GnRH secretion
Herbison, A. E. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100837 · Cited by 125 · see citing works
Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept
Hrabovszky, E., Sipos, M. T., Molnár, C. S., Ciofi, P., Borsay, B. Á., Gergely, P., Herczeg, L., Bloom, S. R., Ghatei, M. A., Dhillo, W. S., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1545 · Cited by 124 · see citing works
Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep
Nestor, C. C., Briscoe, A. M. S., Davis, S. M., Valent, M., Goodman, R. L., & Hileman, S. M. (2012) · Endocrinology · doi:10.1210/en.2011-2009 · Cited by 118 · see citing works
Kisspeptins and GnRH neuronal signalling
Colledge, W. H. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.10.005 · Cited by 120 · see citing works
Seasonal control of gonadotropin-inhibitory hormone (GnIH) in birds and mammals
Kriegsfeld, L. J., Ubuka, T., Bentley, G. E., & Tsutsui, K. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.001 · Cited by 117 · see citing works
Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty
Clarkson, J., Han, S., Liu, X., Lee, K., & Herbison, A. E. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.026 · Cited by 115 · see citing works
Sex steroid control of hypothalamic Kiss1 expression in sheep and rodents: Comparative aspects
Smith, J. T. (2008) · Peptides · doi:10.1016/j.peptides.2008.08.013 · Cited by 115 · see citing works
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system
Mead, E. J., Maguire, J. J., Kuc, R. E., & Davenport, A. P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707295 · Cited by 115 · see citing works
International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function
Kirby, H. R., Maguire, J. J., Colledge, W. H., & Davenport, A. P. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002774 · Cited by 109 · see citing works
Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe
Backholer, K., Smith, J., & Clarke, I. J. (2009) · Endocrinology · doi:10.1210/en.2009-0604 · Cited by 109 · see citing works
Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction
Uenoyama, Y., Nagae, M., Tsuchida, H., Inoue, N., & Tsukamura, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724632 · Cited by 112 · see citing works
Genetic Aspects of Reproduction in Sheep
Notter, D. R. (2008) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2008.01151.x · Cited by 105 · see citing works
Kisspeptin and the seasonal control of reproduction in hamsters
Simonneaux, V., Ansel-Bollepalli, L., Revel, F. G., Klosen, P., Pévet, P., & Mikkelsen, J. D. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.006 · Cited by 106 · see citing works
Redefining the Limits of Day Length Responsiveness in a Seasonal Mammal
Wagner, G., Johnston, J. D., Clarke, I. J., Lincoln, G. A., & Hazlerigg, D. G. (2007) · Endocrinology · doi:10.1210/en.2007-0658 · Cited by 106 · see citing works
Kisspeptin neurons from mice to men: similarities and differences
Goodman, R. L., & Lehman, M. N. (2012) · Endocrinology · doi:10.1210/en.2012-1550 · Cited by 103 · see citing works
Kisspeptin immunoreactive neurons in the equine hypothalamus
Decourt, C., Tillet, Y., Caraty, A., Franceschini, I., & Briant, C. (2008) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2008.07.008 · Cited by 102 · see citing works
Shift in Kiss1 cell activity requires estrogen receptor α
Frazão, R., Cravo, R. M., Donato, J., Ratra, D. V., Clegg, D., Elmquist, J., Zigman, J., Williams, K. W., & Elias, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1610-12.2013 · Cited by 84 · see citing works
Kisspeptin and GnRH Pulse Generation
Okamura, H., Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y., & Maeda, K. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_14 · Cited by 101 · see citing works
Differential Regulation of Kiss1 Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters
Ansel-Bollepalli, L., Bolborea, M., Bentsen, A. H., Klosen, P., Mikkelsen, J. D., & Simonneaux, V. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410361918 · Cited by 101 · see citing works
Mechanisms underlying reduced fertility in anovular dairy cows
Santos, J. E. P., Bisinotto, R. S., & Ribeiro, E. S. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.04.038 · Cited by 98 · see citing works
Insulin-Like Growth Factor-I Activates KiSS-1 Gene Expression in the Brain of the Prepubertal Female Rat
Hiney, J. K., Srivastava, V. K., Pine, M. D., & Dees, W. L. (2008) · Endocrinology · doi:10.1210/en.2008-0954 · Cited by 99 · see citing works
Melatonin Controls Seasonal Breeding by a Network of Hypothalamic Targets
Revel, F. G., Masson‐Pévet, M., Pévet, P., Mikkelsen, J. D., & Simonneaux, V. (2009) · Neuroendocrinology · doi:10.1159/000219588 · Cited by 97 · see citing works
Kisspeptins and the control of gonadotropin secretion in male and female rodents
Roa, J., Castellano, J. M., Navarro, V. M., Handelsman, D. J., Pinilla, L., & Tena‐Sempere, M. (2008) · Peptides · doi:10.1016/j.peptides.2008.08.009 · Cited by 97 · see citing works
Estradiol modulates Kiss1 neuronal response to ghrelin
Frazão, R., Lemko, H. M. D., da Silva, R. P., Ratra, D. V., Lee, C. E., Williams, K. W., Zigman, J. M., & Elias, C. F. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00211.2013 · Cited by 96 · see citing works
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders
Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Richardson, R. E., Sykes, C. M., Phumsatitpong, C., Mills, E., Modi, M., Izzi‐Engbeaya, C. N., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci139681 · Cited by 99 · see citing works
Gonadotropin-releasing hormone plasticity: A comparative perspective
Stevenson, T. J., Hahn, T. P., MacDougall‐Shackleton, S. A., & Ball, G. F. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.001 · Cited by 94 · see citing works
Sex Steroid Regulation of Kisspeptin Circuits
Smith, J. T. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_13 · Cited by 90 · see citing works
Neuroanatomy of the Human Hypothalamic Kisspeptin System
Hrabovszky, E. (2013) · Neuroendocrinology · doi:10.1159/000356903 · Cited by 88 · see citing works
Hypothalamus as an Endocrine Organ
Clarke, I. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140019 · Cited by 104 · see citing works
Kisspeptin expression in the brain: Catalyst for the initiation of puberty
Smith, J. T., & Clarke, I. J. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9026-4 · Cited by 86 · see citing works
Interactions between nutrition and reproduction in the management of the mature male ruminant
Martin, G. B., Blache, D., Miller, D. W., & Vercoe, P. E. (2010) · animal · doi:10.1017/s1751731109991674 · Cited by 89 · see citing works
Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats
Wakabayashi, Y., Yamamura, T., Sakamoto, K., Mori, Y., & OKAMURA, H. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-136 · Cited by 84 · see citing works
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0013-7227/07/$15.00/0 Endocrinology 148(3):1150–1157 Printed in U.S.A. Copyright © 2007 by The Endocrine Society doi: 10.1210/en.2006-1435 KiSS-1 Messenger Ribonucleic Acid Expression in the Hypothalamus of the Ewe Is Regulated by Sex Steroids and Season
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Authors: Smith, J. T., Clay, C. M., Caraty, A., & Clarke, I. J.
Affiliations: Monash University (AU)
Colorado State University (US)
Université de Tours (FR)
Corresponding author: Clarke, Iain J.
ORCID: Clay, Colin M.
Clarke, Iain J.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2007-03
Volume: 148
Issue: 3
Pages: 1150-1157
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2006-1435
OpenAlex: W2058782486
Cited by: 404
References: 73
Citations by year: 2026: 4 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 17 · 2021: 26 · 2020: 16 · 2019: 18 · 2018: 30 · 2017: 16 · 2016: 18 · 2015: 25 · 2014: 22 · 2013: 35 · 2012: 32
FWCI: 24.93
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Monash University
Medical Research Council
National Health and Medical Research Council
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: KISS1, kisspeptin, GPR54, hypothalamus, arcuate nucleus, ewes, sex steroids, estradiol, progesterone, ovariectomy, seasonal reproduction, anestrus, GnRH secretion, puberty, negative feedback, kisspeptin receptor
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Estradiol, Female, Gene Expression Regulation, Hypothalamus, Ovariectomy, Progesterone, RNA, Messenger, Seasons, Gonadal Steroid Hormones, Sheep, Tissue Distribution, Tumor Suppressor Proteins

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KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season

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