Cyclosporin A: alterations of the cellular immune response in S-antigen-induced experimental autoimmune uveitis
Abstract
We have previously shown that Cyclosporin A (CsA) is effective in preventing S-antigen (S-Ag)-induced experimental autoimmune uveitis (EAU). Lewis rats, which readily develop EAU, were studied for the alterations in cell-mediated immune functions associated with CsA therapy. Lymph nodes draining the site of S-Ag immunization were significantly smaller in the CsA-treated animals when compared to the nonprotected group (p less than 0.01), and also showed profound histologic alterations when compared to controls. In vitro responses of lymphocytes from lymph node and peripheral blood were greatly diminished in the CsA-treated animals. Sera from rats treated with CsA also were capable of inhibiting in vitro proliferative responses. These findings demonstrate that CsA-treated Lewis rats have alterations in several cell-mediated immune functions, thereby not permitting full development of the immune events that ultimately lead to uveitis.
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The usage of cyclosporine, rapamycin, or daclizumab for uveitis is based on its effectiveness in experimental autoimmune uveitis.
“the usage of cyclosporine, rapamycin, or daclizumab for uveitis is based on its effectiveness in experimental autoimmune uveitis”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Nussenblatt et al., 1983
There are successful therapies for human disease that arose from mouse models.
“there are successful therapies for human disease that arose from mouse models”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Nussenblatt et al., 1983
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- Authors
- Nussenblatt, R. B., Salinas-Carmona, M., Waksman, B. H., & Gery, I.
- Affiliations
- National Multiple Sclerosis Society (US)
- National Institutes of Health (US)
- Venue
- International Archives of Allergy and Applied Immunology
- Publisher
- S. Karger AG
- Published
- 2009-08-04
- Volume
- 70
- Issue
- 4
- Pages
- 289-294
- ISSN
- 0020-5915 (ISSN-L)
- 2571-6662
- OpenAlex
- W2024047721
- Cited by
- 42
- References
- 0
- Citations by year
- 2019: 1 · 2017: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Archives of Allergy and Applied Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- cyclosporine, experimental autoimmune uveitis, S-antigen, cell-mediated immunity, lymph node histopathology, lymphocyte proliferation inhibition, immunosuppression, Lewis rats
- MeSH terms
- Animals, Antigens, Arthritis, Experimental, Cell Division, Cyclosporins, Disease Models, Animal, Female, Immunity, Cellular, Lymph Nodes, Organ Size, Rats, Inbred Lew, Skin Tests, Uveitis, Arrestin, Rats
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