Suppression of Acute Experimental Allergic Encephalomyelitis by the Synthetic Sex Hormone 17-Alpha-Ethinylestradiol: An Immunological Study in the Lewis Rat
Abstract
Induction of experimental allergic encephalomyelitis (EAE) in female Lewis rats led to the well-known clinical symptoms and histological signs. Treatment with the synthetic estrogen 17-α-ethinylestradiol (EE) from day ––4 before induction until day 21 after induction resulted in partial suppression of these signs and symptoms. Analysis of the peripheral blood leukocyte (sub)populations in these treated animals indicated some remarkable changes. However, these changes were also observed without EE treatment. EE treatment of EAE rats resulted in a significant decrease of the relative weights of both thymus and spleen, which changes however were not reflected in the peripheral blood. Apparently the effects of EE treatment on EAE in the present experiments indicate an action locally at the site of the EAE lesion and do not seem to be mediated by gross changes in the levels of peripheral blood leukocytes.
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In EAE, administration of estrogens leads to functional benefits.
“In EAE, administration of estrogens lead to functional benefits 5, 25, 43, 52.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [52]
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A Potential Role for Estrogen in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
OFFNER, H., & POLANCZYK, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.021 · Cited by 102 · see citing works
Taylor, L. C., Gilmore, W., & Matsushima, G. K. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00230.x · Cited by 84 · see citing works
- Authors
- Trooster, W. J., Teelken, A. W., Kampinga, J., Loof, J. G., Nieuwenhuis, P., & Minderhoud, J. M.
- Affiliations
- University of Groningen (NL)
- ORCID
- Nieuwenhuis, P.
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2009-09-03
- Volume
- 102
- Issue
- 2
- Pages
- 133-140
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- OpenAlex
- W2059714334
- Cited by
- 49
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2013: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Archives of Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- experimental autoimmune encephalomyelitis, ethinyl estradiol, synthetic estrogens, immunosuppression, Lewis rats, thymus weight, spleen weight, local immunomodulation, autoimmune disease
- MeSH terms
- Acute Disease, Animals, Corticosterone, Encephalomyelitis, Autoimmune, Experimental, Ethinyl Estradiol, Female, Guinea Pigs, Immunosuppression Therapy, Leukocyte Count, Organ Size, Rats, Inbred Lew, Spleen, Thymus Gland, T-Lymphocyte Subsets, Rats
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