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Inhibition of Allergic Reactions with Antibodies to IgE
Abstract
Numerous clinical studies show that direct interference with the IgE response leads to a decrease or elimination of allergic symptoms. The aim of these studies was to design a therapy aimed at decreasing IgE levels in order to ameliorate atopic disease. To this end, a murine monoclonal antibody, MAE11, directed against IgE was identified, which had all the properties necessary to interfere with IgE responses, but lacked the harmful side effects of inducing receptor cross-linking. The antibody was selected on the basis of its ability to bind circulating IgE at the same site as the high-affinity receptor, thus blocking the binding of IgE to mast cells and basophils. To allow for possible chronic administration and to avoid the problems of antigenicity, MAE11 was humanized. The best of several humanized variants, version 25 (rhumAb-E25) was selected since it possessed binding affinity and biological activity comparable to MAE11. Clinical studies are underway to determine the safety and efficacy of this treatment for allergic rhinitis and asthma.
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Cited by
Busse, W., Corren, J., Lanier, B. Q., McAlary, M., Fowler-Taylor, A., Cioppa, G. D., van As, A., & Gupta, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117880 · Cited by 1,307
Holgate, S. T., Chuchalin, A. G., Hébert, J., Lötvall, J., Persson, G. B., Chung, K. F., Bousquet, J., Kerstjens, H. A., Fox, H., Thirlwell, J., et al. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.1916.x · Cited by 522
Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis☆☆☆★★★
Casale, T. B., Bernstein, I. L., Busse, W. W., LaForce, C. F., Tinkelman, D. G., Stoltz, R. R., Dockhorn, R. J., Reimann, J., Su, J. Q., & Fick Jr., R. B. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70202-1 · Cited by 326
Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria
Kaplan, A. P., Giménez-Arnau, A. M., & Saini, S. S. (2017) · Allergy · doi:10.1111/all.13083 · Cited by 293
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Lane, J. E., Cheyney, J. M., Lane, T. N., Kent, D. E., & Cohen, D. J. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.09.030 · Cited by 188
Metadata
- Authors
- Shields, R. L., Whether, W. R., Zioncheck, K., O’Connell, L., Fendly, B., Presta, L. G., Thomas, D., Saban, R., & Jardieu, P.
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 1995
- Volume
- 107
- Issue
- 1-3
- Pages
- 308-312
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- OpenAlex
- W2009376119
- Cited by
- 183
- References
- 0
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of Allergic Reactions with Antibodies to IgE. https://app.cochat.ai/papers/10.1159/000237010
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- Shields, R. L., Whether, W. R., Zioncheck, K., O’Connell, L., Fendly, B., Presta, L. G., Thomas, D., Saban, R., & Jardieu, P. (1995). Inhibition of Allergic Reactions with Antibodies to IgE. International Archives of Allergy and Immunology. https://doi.org/10.1159/000237010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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