Cited by 178Dementia and Cognitive Impairment ResearchGeriatric Care and Nursing HomesAging, Health, and Disability

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Determinants of Quality of Life in Nursing Home Residents with Dementia

Wetzels, R.B., Zuidema, S.U., de Jonghe, J.F.M., Verhey, F.R.J., Koopmans, R.T.C.M.·2010·Dementia and Geriatric Cognitive Disorders

DOI 10.1159/000280437

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Abstract

Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.

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Authors: Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M.
Affiliations: Radboud University Nijmegen (NL)
Maastricht University Medical Centre (NL)
ORCID: Zuidema, S.U.
Verhey, F.R.J.
Venue: Dementia and Geriatric Cognitive Disorders
Publisher: S. Karger AG
Published: 2010
Volume: 29
Issue: 3
Pages: 189-197
ISSN: 1420-8008 (ISSN-L)
1421-9824
DOI: 10.1159/000280437
OpenAlex: W2073516783
Cited by: 178
References: 54
Citations by year: 2026: 6 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 16 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 7 · 2014: 18 · 2013: 16 · 2012: 9
FWCI: 8.07
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Dementia and Geriatric Cognitive Disorders (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Radboud Universiteit
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: quality of life, dementia, nursing home residents, neuropsychiatric symptoms, psychotropic drug use, agitation, depression, psychosis, psychomotor agitation, cognitive impairment, dementia severity, Global Deterioration Scale, activities of daily living
MeSH terms: Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Data Interpretation, Statistical, Dementia, Drug Utilization, Female, Humans, Length of Stay, Male, Middle Aged, Neuropsychological Tests, Nursing Homes, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotropic Drugs, Quality of Life, Regression Analysis, Sex Factors, Marital Status

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Determinants of Quality of Life in Nursing Home Residents with Dementia

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