Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study
Abstract
CONTEXT: Mild cognitive impairment (MCI) may be a precursor to dementia, at least in some cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI. OBJECTIVE: To estimate the prevalence of neuropsychiatric symptoms in dementia and MCI in a population-based study. DESIGN: Cross-sectional study derived from the Cardiovascular Health Study, a longitudinal cohort study. SETTING AND PARTICIPANTS: A total of 3608 participants were cognitively evaluated using data collected longitudinally over 10 years and additional data collected in 1999-2000 in 4 US counties. Dementia and MCI were classified using clinical criteria and adjudicated by committee review by expert neurologists and psychiatrists. A total of 824 individuals completed the Neuropsychiatric Inventory (NPI); 362 were classified as having dementia, 320 as having MCI; and 142 did not meet criteria for MCI or dementia. MAIN OUTCOME MEASURE: Prevalence of neuropsychiatric symptoms, based on ratings on the NPI in the previous month and from the onset of cognitive symptoms. RESULTS: Of the 682 individuals with dementia or MCI, 43% of MCI participants (n = 138) exhibited neuropsychiatric symptoms in the previous month (29% rated as clinically significant) with depression (20%), apathy (15%), and irritability (15%) being most common. Among the dementia participants, 75% (n = 270) had exhibited a neuropsychiatric symptom in the past month (62% were clinically significant); 55% (n = 199) reported 2 or more and 44% (n = 159) 3 or more disturbances in the past month. In participants with dementia, the most frequent disturbances were apathy (36%), depression (32%), and agitation/aggression (30%). Eighty percent of dementia participants (n = 233) and 50% of MCI participants (n = 139) exhibited at least 1 NPI symptom from the onset of cognitive symptoms. There were no differences in prevalence of neuropsychiatric symptoms between participants with Alzheimer-type dementia and those with other dementias, with the exception of aberrant motor behavior, which was more frequent in Alzheimer-type dementia (5.4% vs 1%; P =.02). CONCLUSIONS: Neuropsychiatric symptoms occur in the majority of persons with dementia over the course of the disease. These are the first population-based estimates for neuropsychiatric symptoms in MCI, indicating a high prevalence associated with this condition as well. These symptoms have serious adverse consequences and should be inquired about and treated as necessary. Study of neuropsychiatric symptoms in the context of dementia may improve our understanding of brain-behavior relationships.
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Case-control studies suggest depressive symptoms are somewhat more common in older people with mild cognitive impairment or dementia than in those without cognitive impairment.
“case-control studies suggest that depressive symptoms are somewhat more common in older people with mild cognitive impairment or dementia compared to those without cognitive impairment”
From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Lyketsos et al., 2002
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
(1987) · PubMed · Cited by 2,657 · see citing works
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065 · see citing works
Self-citationMild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,833 · see citing works
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,774 · see citing works
Telephone Interview for Cognitive Status
Brandt, J., Spencer, M., & Folstein, M. F. (1988) · PsycTESTS Dataset · doi:10.1037/t28542-000 · Cited by 1,504 · see citing works
Lyketsos, C. G., Steinberg, M. I., Tschanz, J. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.708 · Cited by 1,125 · see citing works
Self-citationA 5-month, randomized, placebo-controlled trial of galantamine in AD
Tariot, P. N., Solomon, P. R., Morris, J. C., Kershaw, P. R., Lilienfeld, S., Ding, C., & the Galantamine USA- Study Group (2000) · Neurology · doi:10.1212/wnl.54.12.2269 · Cited by 915 · see citing works
Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.8.1049 · Cited by 744 · see citing works
Katz, I. R., Jeste, D. V., Mintzer, J. E., Clyde, C., Napolitano, J. A., Brecher, M., & The Risperidone Study Group (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0207 · Cited by 741 · see citing works
Surveillance and ascertainment of cardiovascular events
Ives, D. G., Fitzpatrick, A. L., Bild, D. E., Psaty, B. M., Kuller, L. H., Crowley, P. M., Cruise, R. G., & Theroux, S. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00093-9 · Cited by 688 · see citing works
Self-citationFinkel, S. I., Miller, S., Silva, J. C. E., Cohen, G. D., & Sartorius, N. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297003943 · Cited by 651 · see citing works
Behavioral Treatment of Depression in Dementia Patients: A Controlled Clinical Trial
Teri, L. L., Logsdon, R. G., Uomoto, J. M., & McCurry, S. M. (1997) · The Journals of Gerontology Series B · doi:10.1093/geronb/52b.4.p159 · Cited by 641 · see citing works
Lopez, O. L., Jagust, W. J., DeKosky, S. T., Becker, J. T., Fitzpatrick, A., Dulberg, C., Breitner, J., Lyketsos, C., Jones, B., Kawas, C., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.10.1385 · Cited by 618 · see citing works
Self-citationA randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia
Deyn, P. P. D., Rabheru, K., Rasmussen, A. M. L., Bocksberger, J. P., DAUTZENBERG, P. L. J., Eriksson, S., & LAWLOR, B. A. (1999) · Neurology · doi:10.1212/wnl.53.5.946 · Cited by 611 · see citing works
Street, J. S. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.968 · Cited by 583 · see citing works
Recruitment of adults 65 years and older as participants in the cardiovascular health study
Tell, G. S., Fried, L. P., Hermanson, B., Manolio, T. A., Newman, A. B., & Borhani, N. O. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90062-9 · Cited by 558 · see citing works
The Detection of Dementia in the Primary Care Setting
Valcour, V., Masaki, K., Curb, J. D., & Blanchette, P. L. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.19.2964 · Cited by 498 · see citing works
Manolio, T. A., Kronmal, R. A., Burke, G. L., Poirier, V. C., O’Leary, D. H., Gardin, J. M., Fried, L. P., Steinberg, E. P., & Bryan, R. N. (1994) · Stroke · doi:10.1161/01.str.25.2.318 · Cited by 457 · see citing works
The neuropathology of aminergic nuclei in Alzheimer's disease
Zweig, R. M., Ross, C. A., Hedreen, J. C., Steele, C., Cardillo, J. E., Whitehouse, P. J., Folstein, M. F., & Price, D. L. (1988) · Annals of Neurology · doi:10.1002/ana.410240210 · Cited by 446 · see citing works
Efficacy and Tolerability of Carbamazepine for Agitation and Aggression in Dementia
Tariot, P. N., Erb, R., Podgorski, C. A., Cox, C., Patel, S., Jakimovich, L., & Irvine, C. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.54 · Cited by 422 · see citing works
Psychosis of Alzheimer's Disease and Related Dementias: Diagnostic Criteria for a Distinct Syndrome
Jeste, D. V., & Finkel, S. I. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200002000-00004 · Cited by 394 · see citing works
Predicting Time to Nursing Home Care and Death in Individuals With Alzheimer Disease
Stern, Y. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340040030 · Cited by 359 · see citing works
Assessment of Cognitive Decline in the Elderly by Informant Interview
Jorm, A. F., & Korten, A. E. (1988) · The British Journal of Psychiatry · doi:10.1192/bjp.152.2.209 · Cited by 344 · see citing works
Major and minor depression in Alzheimer's disease: prevalence and impact
Lyketsos, C. G., Steele, C., Baker, L., Galik, E. M., Kopunek, S., Steinberg, M., & Warren, A. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.4.556 · Cited by 321 · see citing works
Self-citationNeuropathologic and Neurochemical Correlates of Psychosis in Primary Dementia
Zubenko, G. S., Moossy, J. J., Martinez, A. J., Rao, G., Claassen, D. O., Rosen, J., & Kopp, U. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530180075020 · Cited by 275 · see citing works
Cholinesterase Inhibitors for Alzheimer??s Disease
Grutzendler, J., & Morris, J. C. (2001) · Drugs · doi:10.2165/00003495-200161010-00005 · Cited by 270 · see citing works
Nyth, A. L., Gottfries, C. G., Lyby, K., Smedegaard-Andersen, L., Jp, G.-S., Kristensen, M., Refsum, H. E., Øfsti, E., Eriksson, S., & Syversen, S. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03242.x · Cited by 261 · see citing works
Bryant, J., Clegg, A. P., Nicholson, T., McIntyre, L., Broe, S. D., Gerard, K., & Waugh, N. R. (2001) · Health Technology Assessment · doi:10.3310/hta5010 · Cited by 246 · see citing works
Evaluation of Dementia in the Cardiovascular Health Cognition Study
López, O. L., Kuller, L. H., Fitzpatrick, A. L., Ives, D. G., Becker, J. T., & Beauchamp, N. (2003) · Neuroepidemiology · doi:10.1159/000067110 · Cited by 238 · see citing works
Self-citationDevanand, D. P., Marder, K. S., Michaels, K. S., Sackeïm, H. A., Bell, K. L., Sullivan, M. A., Cooper, T. B., Pelton, G. H., & Mayeux, R. P. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.11.1512 · Cited by 236 · see citing works
Neurochemical Correlates of Major Depression in Primary Dementia
Zubenko, G. S., Moossy, J. J., & Kopp, U. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530020117023 · Cited by 232 · see citing works
A Validation Study of the Dementia Questionnaire
Kawas, C. H., Segal, J., Stewart, W. F., Corrada, M. M., & Thal, L. J. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210073015 · Cited by 231 · see citing works
Lyketsos, C. G., Leoutsakos, J., Steele, C. D., Kopunek, S., Steinberg, M., Baker, A. S., Brandt, J., & Rabins, P. V. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1686 · Cited by 214 · see citing works
Self-citationSchneider, L. S. S., Tariot, P. N., Lyketsos, C. G., Dagerman, K., Davis, K. L., Thomas, S., Hsiao, J., Jeste, D. V., Katz, I. R., Olin, J. T., et al. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200111000-00004 · Cited by 211 · see citing works
Self-citationClinical and neuropathological correlates of depression in Alzheimer's disease
Förstl, H., Burns, A. S., Luthert, P. J., Cairns, N. J., Lantos, P. L., & Levy, R. (1992) · Psychological Medicine · doi:10.1017/s0033291700038459 · Cited by 208 · see citing works
Placebo-Controlled Study of Divalproex Sodium for Agitation in Dementia
Porsteinsson, A. P., Tariot, P. N., Erb, R., Cox, C., Smith, E., Jakimovich, L. J., Noviasky, J. A., Kowalski, N., Holt, C. J., & Irvine, C. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200102000-00009 · Cited by 206 · see citing works
Roth, M., Mountjoy, C. Q., Amrein, R., & The International Collaborative Study Group (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.2.149 · Cited by 187 · see citing works
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R. C., & STARKSTEIN, S. E. (1996) · Journal of Neuropsychiatry · doi:10.1176/jnp.8.3.270 · Cited by 176 · see citing works
Dopamine Receptor Genetic Variation, Psychosis, and Aggression in Alzheimer Disease
Sweet, R. A., Nimgaonkar, V. L., Kamboh, M. I., López, O. L., Zhang, F., & DeKosky, S. T. (1998) · Archives of Neurology · doi:10.1001/archneur.55.10.1335 · Cited by 164 · see citing works
Self-citationRabins, P. V., Lyketsos, C. G., & Steele, C. D. (2006) · Oxford University Press eBooks · doi:10.1093/med/9780195169782.001.0001 · Cited by 146 · see citing works
Self-citationA SPECT study of delusions in Alzheimer's disease
STARKSTEIN, S. E., Vázquez, S., Petracca, G., Sabe, L., Migliorelli, R., Tesón, A., & Leiguarda, R. C. (1994) · Neurology · doi:10.1212/wnl.44.11.2055 · Cited by 123 · see citing works
Lyketsos, C. G., Breitner, J. C. S., & Rabins, P. V. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.440 · Cited by 94 · see citing works
Self-citationSerotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms
PROCTER, A. W., Francis, P. T., Stratmann, G. C., & Bowen, D. M. (1992) · Neurochemical Research · doi:10.1007/bf00993268 · Cited by 65 · see citing works
Shankle, W. R., Nielson, K. A., & Cotman, C. W. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199500940-00010 · Cited by 55 · see citing works
Victoroff, J., Zarow, C., Mack, W. J., Hsu, E., & Chui, H. C. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550050058024 · Cited by 50 · see citing works
Shankle, W. R., Nielson, K. A., & Cotman, C. W. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199509040-00010 · Cited by 49 · see citing works
Devi, G. (2000) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12.3.411 · Cited by 47 · see citing works
Predicting time to nursing home care and death in individuals with Alzheimer disease
Stern, Y. (1997) · JAMA · doi:10.1001/jama.277.10.806 · Cited by 46 · see citing works
Lyketsos, C. G., Corazzini, K., & Steele, C. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.3.350 · Cited by 36 · see citing works
Self-citationPlacebo-Controlled Study of Divalproex Sodium for Agitation in Dementia
Porsteinsson, A. P. (2001) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.9.1.58 · Cited by 36 · see citing works
Dementia in the hospitalized elderly—a study of 100 consecutive cases in Singapore
Sahadevan, S., Lim, P. P. J., & Choo, P. W. J. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199904)14:4 · Cited by 16 · see citing works
Self-citationCholinesterase inhibitors for Alzheimer's disease
Schneider, L. S. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11329-8 · Cited by 12 · see citing works
A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia
Cummings, J. L. (2000) · Current Psychiatry Reports · doi:10.1007/s11920-000-0025-3 · Cited by 12 · see citing works
Neuropsychiatric symptoms in dementia
Tan, E. Y. L. (2022) · doi:10.26481/dis.20221104et · Cited by 1 · see citing works
Gonzalez-Salvador (1999) · doi:10.1002/(sici)1099-1166(199909)14:9
Self-citation
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Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Behavioral and psychological symptoms of dementia
Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00073 · Cited by 1,425 · see citing works
O'Brien, J. T., & Thomas, A. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00463-8 · Cited by 1,136 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease
Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., Cedarbaum, J., Brashear, R., & Miller, D. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2410 · Cited by 1,139 · see citing works
Self-citationSex differences in Alzheimer disease — the gateway to precision medicine
for the Women’s Brain Project and the Alzheimer Precision Medicine Initiative, Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., Baracchi, F., Girouard, H., Misoch, S., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0032-9 · Cited by 1,009 · see citing works
Clinical Practice Recommendations
Fowler, M. J. (2011) · Clinical Diabetes · doi:10.2337/diaclin.29.4.163 · Cited by 996 · see citing works
2012 Alzheimer's disease facts and figures Alzheimer's Association ∗
Thies, W. H., & Bleiler, L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.001 · Cited by 984 · see citing works
Zhao, Q.-F., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Xu, W., Li, J.-Q., Wang, J., Lai, T.-J., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.069 · Cited by 916 · see citing works
Prevalence of Cognitive Impairment without Dementia in the United States
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-6-200803180-00005 · Cited by 927 · see citing works
Recurrent Concussion and Risk of Depression in Retired Professional Football Players
GUSKIEWICZ, K. M., MARSHALL, S. W., BAILES, J., MCCREA, M., HARDING, H. P., MATTHEWS, A., MIHALIK, J. R., & CANTU, R. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180383da5 · Cited by 928 · see citing works
Petersen, R. C. (2016) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000313 · Cited by 925 · see citing works
Effectiveness of Collaborative Care for Older Adults With Alzheimer Disease in Primary Care
Callahan, C. M., Boustani, M. A., Unverzagt, F. W., Austrom, M. G., Damush, T. M., Perkins, A. J., Fultz, B. A., Hui, S. L., Counsell, S. R., & Hendrie, H. C. (2006) · JAMA · doi:10.1001/jama.295.18.2148 · Cited by 799 · see citing works
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence
Sink, K. M., Holden, K. F., & Yaffe, K. (2005) · JAMA · doi:10.1001/jama.293.5.596 · Cited by 910 · see citing works
Podewils, L. J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi092 · Cited by 675 · see citing works
Rolland, Y., Pillard, F., Klapouszczak, A., Reynish, E., Thomas, D., Andrieu, S., Rivière, D., & Vellas, B. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01035.x · Cited by 661 · see citing works
Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders
Robert, P., Onyike, C., Leentjens, A., Dujardin, K., Aalten, P., Starkstein, S., Verhey, F., Yessavage, J., Clément, J., Drapier, D., et al. (2009) · European psychiatry · doi:10.1016/j.eurpsy.2008.09.001 · Cited by 635 · see citing works
Late-Life Depression, Mild Cognitive Impairment, and Dementia: Possible Continuum?
Panza, F., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Imbimbo, B. P., Santamato, A., Vendemiale, G., Seripa, D., Pilotto, A., et al. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181b0fa13 · Cited by 609 · see citing works
Livingston, G., Johnston, K., Katona, C., Paton, J., Lyketsos, C. G., & Old Age Task Force of the World Federation of Biological Psychiatry (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.1996 · Cited by 591 · see citing works
Self-citationHalagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580 · see citing works
Boustani, M. A., Peterson, B., Hanson, L. C., Harris, R., & Lohr, K. N. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-11-200306030-00015 · Cited by 573 · see citing works
Wang, C., & Holtzman, D. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 589 · see citing works
Benzodiazepine use and risk of Alzheimer's disease: case-control study
de Gage, S. B., Moride, Y., Ducruet, T., Kurth, T., Verdoux, H., Tournier, M., Pariente, A., & Bégaud, B. (2014) · BMJ · doi:10.1136/bmj.g5205 · Cited by 560 · see citing works
Modrego, P. J., & Ferrández, J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1290 · Cited by 537 · see citing works
Ismail, Z., Elbayoumi, H., Fischer, C. E., Hogan, D. B., Millikin, C. P., Schweizer, T., Mortby, M. E., Smith, E. E., Patten, S. B., & Fiest, K. M. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3162 · Cited by 532 · see citing works
Aarsland, D., Brønnick, K., Ehrt, U., Deyn, P. P. D., Tekin, S., Emre, M., & Cummings, J. L. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.083113 · Cited by 519 · see citing works
Prospective Study of Alcohol Consumption and Risk of Dementia in Older Adults
Mukamal, K. J., Kuller, L. H., Fitzpatrick, A. L., Longstreth, W. T., Mittleman, M. A., & Siscovick, D. S. (2003) · JAMA · doi:10.1001/jama.289.11.1405 · Cited by 520 · see citing works
Self-citationKelly, M. E., Loughrey, D., Lawlor, B. A., Robertson, I. H., Walsh, C., & Brennan, S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.004 · Cited by 509 · see citing works
Bahar-Fuchs, A., Clare, L., & Woods, B. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003260.pub2 · Cited by 507 · see citing works
Does retirement affect cognitive functioning?
Bonsang, É., Adam, S., & Sergio Perelman, A. (2012) · Journal of Health Economics · doi:10.1016/j.jhealeco.2012.03.005 · Cited by 470 · see citing works
Barnes, D. E., Alexopoulos, G. S., Lopez, O. L., Williamson, J. D., & Yaffe, K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.273 · Cited by 465 · see citing works
Prevalence of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Normal Cognitive Aging
Geda, Y. E., Roberts, R. O., Knopman, D. S., Petersen, R. C., Christianson, T. J. H., Pankratz, V. S., Smith, G. E., Boeve, B. F., Ivnik, R. J., Tangalos, E. G., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.10.1193 · Cited by 437 · see citing works
Predictors of progression from mild cognitive impairment to Alzheimer disease
Palmer, K., Berger, A., Monastero, R., Winblad, B. G., Bäckman, L., & Fratiglioni, L. (2007) · Neurology · doi:10.1212/01.wnl.0000260968.92345.3f · Cited by 436 · see citing works
Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
Buchman, A. S., Boyle, P. A., Wilson, R. S., Tang, Y., & Bennett, D. A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068de1d · Cited by 420 · see citing works
Obesity and cognitive decline: role of inflammation and vascular changes
Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 429 · see citing works
Belleville, S., Gilbert, B., Fontaine, F. S., Gagnon, L., Ménard, É., & Gauthier, S. G. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000096316 · Cited by 420 · see citing works
Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature
Apostolova, L. G., & Cummings, J. L. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000112509 · Cited by 395 · see citing works
Social brain, social dysfunction and social withdrawal
Porcelli, S., van der Wee, N. J. A., van der Werff, S. J., Aghajani, M., Glennon, J. C., van Heukelum, S., Mogavero, F., Lobo, A., Olivera, F. J. N., Lobo, E., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.012 · Cited by 397 · see citing works
Neuropsychiatric Syndromes in Dementia
Aalten, P., Verhey, F. R. J., Boziki, M. K., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., Elina, K., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000110738 · Cited by 388 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., Evans, J., Lee, M., Porsteinsson, A., Lanctôt, K. L., et al. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.12.001 · Cited by 378 · see citing works
Self-citationDistinguishing Alzheimer’s disease from other major forms of dementia
Karantzoulis, S., & Galvin, J. E. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.155 · Cited by 385 · see citing works
Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment
Dotson, V. M., Beydoun, M. A., & Zonderman, A. B. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e62124 · Cited by 385 · see citing works
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374 · see citing works
Implementing a screening and diagnosis program for dementia in primary care
Boustani, M., Callahan, C. M., Unverzagt, F. W., Austrom, M. G., Perkins, A. J., Fultz, B. A., Hui, S. L., & Hendrie, H. C. (2005) · Journal of General Internal Medicine · doi:10.1007/s11606-005-0103-7 · Cited by 374 · see citing works
Savva, G., Zaccai, J., Matthews, F., Davidson, J., McKeith, I., & Brayne, C. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.049619 · Cited by 384 · see citing works
Management of behavioral problems in Alzheimer's disease
Gauthier, S., Cummings, J., Ballard, C., Brodaty, H., Grossberg, G., Robert, P., & Lyketsos, C. (2010) · International Psychogeriatrics · doi:10.1017/s1041610209991505 · Cited by 369 · see citing works
Self-citationThe Mental Health and Substance Use Workforce for Older Adults: In Whose Hands?
Eden, J., Maslow, K., Le, M., & Blazer, D. G. (2013) · Cited by 351 · see citing works
Feldman, H., Ferris, S. H., Winblad, B. G., Sfikas, N., Mancione, L., He, Y., Tekin, S., Burns, A. S., Cummings, J. L., del Ser, T., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70109-6 · Cited by 335 · see citing works
Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives
Ma, L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00009 · Cited by 323 · see citing works
McCurry, S. M., Logsdon, R. G., Teri, L. L., & Vitiello, M. V. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.09.002 · Cited by 315 · see citing works
Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives
Rolland, Y., Abellan van Kan, G., & Vellas, B. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.02.007 · Cited by 312 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302 · see citing works
Self-citationAntidepressants for agitation and psychosis in dementia
Seitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008191.pub2 · Cited by 304 · see citing works
Best practice in the management of behavioural and psychological symptoms of dementia
Tible, O., Riese, F., Savaskan, E., & von Gunten, A. (2017) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285617712979 · Cited by 302 · see citing works
A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment
Monastero, R., Mangialasche, F., Camarda, C., Ercolani, S., & Camarda, R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1120 · Cited by 297 · see citing works
Caregiver Burden in Alzheimer Disease: Cross-Sectional and Longitudinal Patient Correlates
Mohamed, S., Rosenheck, R. A., Lyketsos, C. G., & Schneider, L. S. S. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181d5745d · Cited by 291 · see citing works
Self-citationLate-Life Anxiety and Cognitive Impairment: A Review
Beaudreau, S. A., & O'Hara, R. M. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817945c3 · Cited by 290 · see citing works
Nelson, J. C., & Devanand, D. P. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03355.x · Cited by 284 · see citing works
Perspectives on Depression, Mild Cognitive Impairment, and Cognitive Decline
Steffens, D. C., Otey, E., Alexopoulos, G. S., Butters, M. A., Cuthbert, B., Ganguli, M., Geda, Y. E., Hendrie, H. C., Krishnan, R. R., Kumar, A., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.130 · Cited by 274 · see citing works
Self-citationPractice constraints, behavioral problems, and dementia care: primary care physicians' perspectives
Hinton, L., Franz, C. E., Reddy, G., Flores, Y., Kravitz, R. L., & Barker, J. C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0317-y · Cited by 268 · see citing works
Development and validation of a short form of the Geriatric Anxiety Inventory – the GAI-SF
Byrne, G. J., & Pachana, N. A. (2011) · International Psychogeriatrics · doi:10.1017/s1041610210001237 · Cited by 273 · see citing works
Selbæk, G., Engedal, K., & Bergh, S. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.09.027 · Cited by 271 · see citing works
Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults
Potvin, O., Lorrain, D., Forget, H., Dubé, M., Grenier, S., Préville, M., & Hudon, C. (2012) · SLEEP · doi:10.5665/sleep.1732 · Cited by 268 · see citing works
de Medeiros, K., Robert, P. H., Gauthier, S. G., Stella, F., Politis, A. M., Leoutsakos, J., Taragano, F. E., Kremer, J., Brugnolo, A., Porsteinsson, A. P., et al. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210000876 · Cited by 266 · see citing works
Self-citationKales, H. C., Valenstein, M., Kim, H. M., McCarthy, J. F., Ganoczy, D., Cunningham, F., & Blow, F. C. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101710 · Cited by 258 · see citing works
Mild Cognitive Impairment is Associated With Characteristic Neuropsychiatric Symptoms
Hwang, T., Masterman, D. L., Ortiz, F., Fairbanks, L. A., & Cummings, J. L. (2004) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200401000-00004 · Cited by 259 · see citing works
Clinical features and multidisciplinary approaches to dementia care
MacDonald, S. W. S., Grand, & Caspar (2011) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s17773 · Cited by 266 · see citing works
Oliveira, A. M. D., Radanovic, M., Mello, P. C. H. D., Buchain, P. C., Vizzotto, A. D. B., Celestino, D. L., Stella, F., Piersol, C. V., & Forlenza, O. V. (2015) · BioMed Research International · doi:10.1155/2015/218980 · Cited by 247 · see citing works
Luis, C. A., Loewenstein, D., Acevedo, A., Barker, W. W., & Duara, R. (2003) · Neurology · doi:10.1212/01.wnl.0000080366.90234.7f · Cited by 245 · see citing works
Livingston, G., Kelly, L., Lewis-Holmes, E., Baio, G., Stephen Morris, A., Patel, N. V., Omar, R., Katona, C., & Cooper, C. (2014) · Health Technology Assessment · doi:10.3310/hta18390 · Cited by 244 · see citing works
Karttunen, K., Karppi, P., Hiltunen, A., Vanhanen, M., Välimäki, T. H., Martikainen, J. A., Valtonen, H. J., Sivenius, J., Soininen, H. S., Hartikainen, S. A., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2550 · Cited by 240 · see citing works
A Cross-Sectional Study of Neuropsychiatric Symptoms in 435 Patients With Alzheimer's Disease
Craig, D., Mirakhur, A., Hart, D. J., McIlroy, S. P., & Passmore, A. P. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.6.460 · Cited by 240 · see citing works
O'Connor, D. W., Ames, D., Gardner, B., & King, M. (2009) · International Psychogeriatrics · doi:10.1017/s1041610208007588 · Cited by 239 · see citing works
Aalten, P., de Vugt, M. E., Jaspers, N., Jolles, J., & Verhey, F. R. J. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1316 · Cited by 239 · see citing works
Law, C.-K., Lam, F. M., Chung, R. C., & Pang, M. Y. (2020) · Journal of Physiotherapy · doi:10.1016/j.jphys.2019.11.014 · Cited by 243 · see citing works
Awata, S., Bech, P., Koizumi, Y., Seki, T., Kuriyama, S., Hozawa, A., Ohmori, K., Nakaya, N., Matsuoka, H., & Tsuji, I. (2006) · International Psychogeriatrics · doi:10.1017/s1041610206004212 · Cited by 231 · see citing works
Geda, Y. E., Knopman, D. S., Mrazek, D. A., Jicha, G. A., Smith, G. E., Negash, S., Boeve, B. F., Ivnik, R. J., Petersen, R. C., Pankratz, V. S., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.3.435 · Cited by 230 · see citing works
Depression in Alzheimer’s disease: heterogeneity and related issues
Lee, H. B., & Lyketsos, C. G. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00543-2 · Cited by 230 · see citing works
Self-citationAging and mental health in the decade ahead: What psychologists need to know
Karel, M. J., Gatz, M., & Smyer, M. A. (2012) · American Psychologist · doi:10.1037/a0025393 · Cited by 228 · see citing works
Art Therapy for Alzheimer's Disease and Other Dementias
Chancellor, B., Duncan, A. C., & Chatterjee, A. K. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131295 · Cited by 228 · see citing works
Mild Behavioral Impairment and Risk of Dementia
Taragano, F. E., Allegri, R., Krupitzki, H. B., Sarasola, D., Serrano, C. M., Loñ, L., & Lyketsos, C. G. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04181 · Cited by 225 · see citing works
Self-citationChen, Y., Dang, M., & Zhang, Z. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00456-1 · Cited by 224 · see citing works
Diagnostic criteria for apathy in clinical practice
Mulin, E., Leone, E., Dujardin, K., Delliaux, M., Leentjens, A. F. G., Nobili, F. M., Dessi, B., Tible, O., Agüera-Ortíz, L., Osorio, R. S., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2508 · Cited by 221 · see citing works
Behavioural changes and psychological symptoms in dementia disorders
McKeith, I. G., & Cummings, J. L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70219-2 · Cited by 222 · see citing works
Apathy associated with neurocognitive disorders: Recent progress and future directions
Lanctôt, K. L., Agüera-Ortíz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.05.008 · Cited by 222 · see citing works
Selectivity of executive function deficits in mild cognitive impairment.
Brandt, J., Aretouli, E., Neijstrom, E., Samek, J., Manning, K. J., Albert, M., & Bandeen‐Roche, K. (2009) · Neuropsychology · doi:10.1037/a0015851 · Cited by 219 · see citing works
Behavioral symptoms in mild cognitive impairment
Feldman, H., Scheltens, P., Scarpini, E. A., Hermann, N., Mesenbrink, P. G., Mancione, L., Tekin, S., Lane, R. M., & Ferris, S. H. (2004) · Neurology · doi:10.1212/01.wnl.0000118301.92105.ee · Cited by 219 · see citing works
Sleep disorders in aging and dementia
Bombois, S., Derambure, P., Pasquier, F., & Monaca, C. C. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0052-7 · Cited by 220 · see citing works
Bidirectional Relationship between Cognitive Function and Pneumonia
Shah, F. A., Pike, F., Alvarez, K., Angus, D. C., Newman, A. B., López, O. L., Tate, J. A., Kapur, V. K., Wilsdon, A., Krishnan, J. A., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2154oc · Cited by 215 · see citing works
Okura, T., Plassman, B. L., Steffens, D. C., Llewellyn, D. J., Potter, G. G., & Langa, K. M. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02680.x · Cited by 215 · see citing works
Deep representation learning of electronic health records to unlock patient stratification at scale
Landi, I., Glicksberg, B. S., Lee, H.-C., Cherng, S., Landi, G., Danieletto, M., Dudley, J. T., Furlanello, C., & Miotto, R. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0301-z · Cited by 213 · see citing works
Physical Training Improves Motor Performance in People with Dementia: A Randomized Controlled Trial
Hauer, K. A., Schwenk, M., Zieschang, T., Essig, M., Becker, C., & Oster, P. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03778.x · Cited by 209 · see citing works
Contribution of Depression to Cognitive Impairment and Dementia in Older Adults
Potter, G. G., & Steffens, D. C. (2007) · The Neurologist · doi:10.1097/01.nrl.0000252947.15389.a9 · Cited by 210 · see citing works
Teng, E., Lu, P. H., & Cummings, J. L. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107100 · Cited by 208 · see citing works
Dementia Prevention and Treatment
Reuben, D. B., Kremen, S. A., & Maust, D. T. (2024) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.8522 · Cited by 214 · see citing works
Aalten, P., Verhey, F. R. J., Boziki, M. K., Brugnolo, A., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111082 · Cited by 207 · see citing works
Longitudinal Associations Between Visual Impairment and Cognitive Functioning
Zheng, D. D., Swenor, B. K., Christ, S. L., West, S. K., Lam, B. L., & Lee, D. J. (2018) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2018.2493 · Cited by 208 · see citing works
Sosa, A. L., Albanese, E., Stephan, B. C. M., Dewey, M. E., Acosta, D. M., Ferri, C. P., Guerra, M., Huang, Y., Jacob, K. S., Jiménez‐Velázquez, I. Z., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001170 · Cited by 202 · see citing works
- Authors
- Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S.
- Affiliations
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- Wake Forest University (US)
- University of Washington (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2002-09-25
- Volume
- 288
- Issue
- 12
- Pages
- 1475
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2088361570
- Cited by
- 2,049
- References
- 57
- Citations by year
- 2026: 57 · 2025: 94 · 2024: 105 · 2023: 99 · 2022: 98 · 2021: 117 · 2020: 115 · 2019: 104 · 2018: 109 · 2017: 101 · 2016: 98 · 2015: 92 · 2014: 93 · 2013: 97 · 2012: 98
- FWCI
- 24.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc085079-024, n01hc015103-009, 5r01mh056511-05, n01hc085086-022, n01hc035129-010)
- National Institute on Aging (R01 AG 11380, R01AG011380, 5R01 AG 15928-02, R01AG015928)
- National Heart, Lung, and Blood Institute (N01HC15103, N01 HC85086, N01-HC85079, N01HC35129)
- National Institute of Mental Health (R01 MH 56511)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- neuropsychiatric symptoms, dementia, mild cognitive impairment, prevalence, Neuropsychiatric Inventory, depression, apathy, irritability, agitation, aberrant motor behavior, Alzheimer-type dementia, Cardiovascular Health Study, population-based study, symptom onset timing, aberrant behavior
- MeSH terms
- Aged, Aggression, Anxiety, Feeding and Eating Disorders, Behavioral Symptoms, Cognition Disorders, Cross-Sectional Studies, Delusions, Dementia, Depression, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Sleep Wake Disorders, Comorbidity, Prevalence
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