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Studies on Blood Coagulation and Fibrinolysis in Pregnancy, during Delivery and in the Puerperium
Abstract
Blood coagulation and fibrinolytic variables were investigated with recently developed laboratory methods during normal pregnancy, at delivery and during puerperium. The state of hypercoagulability was registered by an increase in activity of factors XII, X and VIII, in VIII antigen, in ratio between VIII antigen and activity as well as in fibrinogen. Activation of blood coagulation at delivery results in decreasing levels of factors XII and XI and an increase in fibrinopeptide A. However, normal mean values of antithrombin and platelets were observed. An increase is noted in the plasminogen level as well as in urokinase inhibitor during pregnancy. In addition alpha 2-antiplasmin and prekallikrein were studied; however, no marked changes were noted.
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Citations
Cited by
Haemostatic changes in pregnancy
Bremme, K. A. (2003) · Best Practice & Research Clinical Haematology · doi:10.1016/s1521-6926(03)00021-5 · Cited by 869
Hemostasis during normal pregnancy and puerperium
Hellgren, M. (2003) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2003-38897 · Cited by 492
Jacobsen, A. F., Skjeldestad, F. E., & Sandset, P. M. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.08.041 · Cited by 470
Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy
Brennand, J., Conkie, J. A., McCall, F., Greer, I. A., Walker, I., & Clark, P. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615035 · Cited by 386
Dahlman, T. C. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90378-v · Cited by 379
Metadata
- Authors
- Hellgren, M., & Blombäck, M.
- Venue
- Gynecologic and Obstetric Investigation
- Publisher
- S. Karger AG
- Published
- 1981
- Volume
- 12
- Issue
- 3
- Pages
- 141-154
- ISSN
- 0378-7346 (ISSN-L)
- 1423-002X
- OpenAlex
- W2057616710
- Cited by
- 234
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Studies on Blood Coagulation and Fibrinolysis in Pregnancy, during Delivery and in the Puerperium. https://app.cochat.ai/papers/10.1159/000299596
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- Hellgren, M., & Blombäck, M. (1981). Studies on Blood Coagulation and Fibrinolysis in Pregnancy, during Delivery and in the Puerperium. Gynecologic and Obstetric Investigation. https://doi.org/10.1159/000299596
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.