The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy
Abstract
Summary: A prospective study of activated protein C sensitivity, protein C, protein S, and other coagulation factors in 239 women during normal pregnancy was carried out. Protein C activity appeared unaffected by gestation, although an elevation of protein C activity was observed in the early puerperium. A fall in total and free protein S with increasing gestation was observed. Activated protein C sensitivity ratio (APC:SR) showed a progressive fall through pregnancy. This fall correlated with changes in factor VIIIc, factor Vc and protein S. 38% of subjects, with no evidence of Factor V Leiden or anticardiolipin antibodies, showed a low APC:SR (APC:SR <2.6) in the third trimester of pregnancy. Aside from a significant reduction in birth weight, no difference in pregnancy outcome was observed between these subjects and those with a normal APC:SR. Activated protein C sensitivity ratio, modified by pre-dilution of patient samples with factor V depleted plasma, showed no consistent trend with gestation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation in blood coagulation factor V associated with resistance to activated protein C
Bertina, R. M., Koeleman, B. P. C., Koster, T., Rosendaal, F. R., Dirven, R. J., de Ronde, H., van der Velden, P. A., & Reitsma, P. H. (1994) · Nature · doi:10.1038/369064a0 · Cited by 3,783
Dahlbäck, B., Carlsson, M., & Svensson, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.1004 · Cited by 1,945
Koster, T., Vandenbroucke, J., Rosendaal, F., de Ronde, H., Briët, E., & Bertina, R. (1993) · The Lancet · doi:10.1016/s0140-6736(05)80081-9 · Cited by 1,239
Increased fetal loss in women with heritable thrombophilia
Preston, F., Rosendaal, F., Walker, I., Briët, E., Berntorp, E., Conard, J., Fontcuberta, J., Makris, M., Mariani, G., Noteboom, W., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04125-6 · Cited by 661
Self-citationHaemostasis in Normal Pregnancy
Stirling, Y., Woolf, L., North, W. R. S., Seghatchian, M. J., & Meade, T. W. (1984) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1661167 · Cited by 600
Underlying disorders associated with severe early-onset preeclampsia
Dekker, G. A., de Vries, J. I. P., Doelitzsch, P. M., Huijgens, P. C., von Blomberg, B. M. E., Jakobs, C., & van Geijn, H. P. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91324-6 · Cited by 511
Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]
Griffin, J., Evatt, B., Wideman, C., & Fernandez, J. (1993) · Blood · doi:10.1182/blood.v82.7.1989.1989 · Cited by 417
Lockwood, C. J., Romero, R., Feinberg, R. F., Clyne, L. P., Coster, B., & Hobbins, J. C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90522-x · Cited by 359
Functional and immunologic protein S levels are decreased during pregnancy
Comp, P., Thurnau, G., Welsh, J., & Esmon, C. (1986) · Blood · doi:10.1182/blood.v68.4.881.881 · Cited by 353
Malm, J., Laurell, M., & Dahlbäck, B. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb04232.x · Cited by 245
Cited by
Manifestations of chronic disease during pregnancy
Kaaja, R. J. (2005) · JAMA · doi:10.1001/jama.294.21.2751 · Cited by 382
Thachil, J., & Toh, C.-H. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.002 · Cited by 177
Erez, O., Novack, L., Beer-Weisel, R., Dukler, D., Press, F., Zlotnik, A., Than, N. G., Tomer, A., & Mazor, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093240 · Cited by 146
“In addition, systemic changes are observed in the maternal plasma including : 1) increased concentrations of clotting factors VII, VIII, IX, X and XII [3,9–13] and fibrinogen; 2) a reduction in the concentration of anticoagulant proteins such as protein S and tissue factor pathway inhibitor (TFPI)-1 [14–18]; 3) acquir…”
BackgroundThrombophilia and pregnancy loss
Regan, L., & Rai, R. (2002) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00144-9 · Cited by 69
Metadata
- Authors
- Brennand, J., Conkie, J. A., McCall, F., Greer, I. A., Walker, I., & Clark, P.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998
- Volume
- 79
- Issue
- 06
- Pages
- 1166-1170
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W1833068323
- Cited by
- 386
- References
- 25
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy. https://app.cochat.ai/papers/10.1055/s-0037-1615035
- The paper
- Brennand, J., Conkie, J. A., McCall, F., Greer, I. A., Walker, I., & Clark, P. (1998). Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0037-1615035
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
