The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Episodes of Overtreatment during the First Six Months in Children with Congenital Hypothyroidism and Their Relationships with Sustained Attention and Inhibitory Control at School Age
Abstract
BACKGROUND/AIMS: Contradictory results regarding the optimal initial dose of levothyroxine in children with congenital hypothyroidism (CH) hamper the clinical management of these children during their early infancy. We explore the relationships between the initial dose of levothyroxine and endocrine control during the first 6 months and cognition at school age. SUBJECTS AND METHODS: Fifty children with CH, 14 boys (10+/-3.1 years) and 36 girls (9.7+/-2.6 years), at the Pediatric Endocrine Unit of the Hospital Gregorio Marañón in Madrid were studied. Neurocognitive evaluation was carried out exploring alertness and inhibitory control. The number of episodes of overtreatment during the first 6 months, the initial dose of levothyroxine, etiology and sex were the predictor variables. RESULTS: Inhibitory control was significantly lower in children with CH than in controls. An interaction with gender and etiology was obtained. Alertness had an inverse relationship with the number of episodes of overtreatment with no interaction with gender or etiology. CONCLUSION: Episodes of overtreatment and not the initial dose of levothyroxine are a risk factor for deficit in alertness whereas subtle inhibitory control deficit seems to be a permanent problem with the current therapeutic approach.
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“Overtreatment during the first months of life (with the exception of fT4 above the normal range with not supressed TSH and/or without signs or symptoms of hyperthyroidism), a critical period for brain development, may be associated with attention deficit at the school age (109,171,172), and lower IQ scores (108,173,174).”
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Léger, J., Olivieri, A., Donaldson, M., Torresani, T., Krude, H., van Vliet, G., Polak, M., Butler, G., & on behalf of ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, A. T. C. H. C. C. G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1891 · Cited by 569
van Trotsenburg, P., Stoupa, A., Léger, J., Rohrer, T., Peters, C., Fugazzola, L., Cassio, A., Heinrichs, C., Beauloye, V., Pohlenz, J., et al. (2021) · Thyroid® · doi:10.1089/thy.2020.0333 · Cited by 469
Bongers-Schokking, J. J., Resing, W. C. M., de Rijke, Y. B., de Ridder, M. A. J., & de Muinck Keizer-Schrama, S. M. P. F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2175 · Cited by 94
Léger, J. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-0777 · Cited by 72
Cassio, A., Monti, S., Rizzello, A., Bettocchi, I., Baronio, F., D'Addabbo, G., Bal, M. O., & Balsamo, A. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.11.070 · Cited by 68
Metadata
- Authors
- Álvarez, M., Iglesias Fernández, C., Rodríguez Sánchez, A., Dulín ĺñiguez, E., & Rodríguez Arnao, M. D.
- Affiliations
- University of Havana (CU)
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 74
- Issue
- 2
- Pages
- 114-120
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W1991787302
- Cited by
- 57
- References
- 45
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- congenital hypothyroidism, overtreatment, levothyroxine, initial dose, hormonal regulation, sustained attention, alertness, inhibitory control, neuropsychological outcomes, elementary school students, thyroid hormone replacement
- MeSH terms
- Child, Congenital Hypothyroidism, Dose-Response Relationship, Drug, Female, Humans, Infant, Male, Thyrotropin, Thyroxine, Linear Models, Hormone Replacement Therapy, Executive Function
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- CoChat. (2026). Citation check: Episodes of Overtreatment during the First Six Months in Children with Congenital Hypothyroidism and Their Relationships with Sustained Attention and Inhibitory Control at School Age. https://app.cochat.ai/papers/10.1159/000313370
- The paper
- Álvarez, M., Iglesias Fernández, C., Rodríguez Sánchez, A., Dulín ĺñiguez, E., & Rodríguez Arnao, M. D. (2010). Episodes of Overtreatment during the First Six Months in Children with Congenital Hypothyroidism and Their Relationships with Sustained Attention and Inhibitory Control at School Age. Hormone Research in Paediatrics. https://doi.org/10.1159/000313370
