The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Meeting the Nutritional Needs of the Low-Birth-Weight Infant
Abstract
Delivering adequate amounts of nutrients to premature infants at all times is challenging because the infant’s immature gastrointestinal tract is initially unable to accept feedings, necessitating the use of parenteral nutrition. In the past, inadequate amounts of nutrients have commonly been given to premature infants because the administration of nutrients was thought to be hazardous. Inadequate nutrient intakes have resulted in widespread postnatal growth restriction. Now that it is known that postnatal growth restriction is associated with poor neurocognitive development, efforts are made to increase nutrient intakes. In this review, nutrient requirements of premature infants that have been determined by the factorial and empirical methods are reviewed. Current good practices regarding parenteral nutrition are discussed, as are guidelines for the introduction and advancement of enteral feedings. Because of its trophic effects on the gastrointestinal tract and its anti-infectious effects, human milk is strongly preferred as the early feeding of choice for premature infants. Human milk also protects infants against necrotizing enterocolitis. Once full feeding is achieved, the challenge is to provide nutrients in amounts that support the infant’s growth like that of the fetus. In the case of the infant fed his/her mother’s milk or banked donor milk, nutrient fortification is necessary and is generally practiced. However, adequate intakes of protein are seldom achieved with routine fortification and methods of providing additional fortification are discussed.
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“Further, breastmilk alone may be insufficient to meet the nutritional needs of MLBW infants [42, 44–46]; most facilities did not have alternatives readily available.”
From Facility-based care for moderately low birthweight infants in India, Malawi, and Tanzania (2023) · cites this paper as [45]
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Breast milk and neonatal necrotising enterocolitis
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Ahuja, A., Longkumer, T. P., Sikriwal, D., & Mallaiah, R. (2023) · Journal of Clinical Neonatology · doi:10.4103/jcn.jcn_111_22
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(2020) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610024181-15
Bösi, A. T. B. (2023) · Turkiye Klinikleri Journal of Health Sciences · doi:10.5336/healthsci.2023-99515
Hipermagnesemia e intolerância alimentar em recém-nascido pré-termo
Junqueira, E. O. (2021) · doi:10.47749/t/unicamp.2021.1237630
Amino acid for preterm newborns
Nandhini, G., Kumbamoorthy, S. S., & Sundaresan, S. (2023) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/ijnpnd.ijnpnd_58_23
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Protein and energy digestibility in preterm infants fed fortified human milk
Kappel, S. S., Sangild, P. T., Zachariassen, G., Andersen, J. H., Rasmussen, K. K., Jeppesen, P. B., & Aunsholt, L. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70000
(2025) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610027700-ch14
Protein Requirements in the Neonatal Intensive Care Unit
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Metadata
- Authors
- Ziegler, E. E.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Ziegler, Ekhard E.
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 58
- Issue
- Suppl. 1
- Pages
- 8-18
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2075593674
- Cited by
- 217
- References
- 60
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 25 · 2019: 13 · 2018: 21 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 16 · 2013: 16 · 2012: 7
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- low birth weight infants, preterm infants, nutrient requirements, parenteral nutrition, enteral nutrition, postnatal growth restriction, neurocognitive development, breast milk, donor human milk, necrotizing enterocolitis, nutrient fortification, protein intake, factorial method, empirical methods
- MeSH terms
- Energy Intake, Dietary Proteins, Enteral Nutrition, Food, Fortified, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Milk, Human, Nutritional Requirements, Parenteral Nutrition, Guidelines as Topic, Sepsis, Enterocolitis, Necrotizing, Empirical Research, Infant Formula, Gastrointestinal Tract
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