The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Dot-ELISA vs. PCR of Fine Needle Aspirates of Tuberculous Lymphadenitis
Abstract
Objective To evaluate an in-house dot-enzyme-linked immunosorbent assay (ELISA) for confirmation of clinically suspected cases of tuberculous lymphadenitis (TBLN). Study design The study was performed at the postgraduate departments of microbiology and pathology of a tertiary-care teaching hospital in India. Suspected cases of TBLN were prospectively enrolled. Fine needle aspiration was done of enlarged lymph nodes in all patients, and 2 smears were prepared, 1 for acid-fast bacillus (AFB) demonstration and the other for cytologic examination. The remaining material was tested with in-house dot-ELISA and by IS6110 amplification with polymerase chain reaction (PCR), for diagnosis of TBLN. Results ELISA was more sensitive and detected 93.2% of cases. PCR and fine needle aspiration cytology (FNAC) detected 82.5% and 61.0% cases, respectively. AFB positivity was 33.1%. Conclusion Application of dot-ELISA was more sensitive but less specific as compared to PCR. PCR, though expensive, should be used in problem cases because of its high specificity.
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“Peripheral lymph node involvement is the commonest form of extra pulmonary mycobacterial disease and cervical region is the most frequently affected [3,6,7].”
From Fine needle aspiration cytology in the diagnosis of Tuberculous lymphadenitis and utility of Ziehl Neelsen stain benefits and pitfalls (2016) · cites this paper as [3]
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Efficacy of fine needle aspiration cytology in the diagnosis of tuberculous cervical lymphadenopathy
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Modern laboratory diagnosis of tuberculosis
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Goel, M. M., Ranjan, V., Dhole, T. N., Srivastava, A. N., Mehrotra, A., Kushwaha, M. R. S., & Jain, A. (2001) · Acta Cytologica · doi:10.1159/000327627 · Cited by 77
Self-citationShared Antigens between Mycobacterium bovis (BCG) and Other Bacterial Species
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La tuberculose extrapulmonaire
Mazza‐Stalder, J., Nicod, L. P., & Janssens, J.-P. (2012) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2011.05.021 · Cited by 89
Mittal, P., Handa, U., Mohan, H., & Gupta, V. (2011) · Diagnostic Cytopathology · doi:10.1002/dc.21472 · Cited by 80
Kim, Y. H., Jeong, W., Jung, K., Sung, M., Kim, K. H., & Kim, C. S. (2005) · Acta Oto-Laryngologica · doi:10.1080/00016480510012246 · Cited by 78
Tuberculous Lymphadenitis in Northern Ethiopia: In a Public Health and Microbiological Perspectives
Biadglegne, F., Tesfaye, W., Sack, U., & Rodloff, A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081918 · Cited by 35
Thyroid tuberculosis – role of PCR in diagnosis of a rare entity
Gupta, N., Sharma, K., Barwad, A. W., Sharma, M. L., Rajwanshi, A., Dutta, P., & Sharma, A. (2010) · Cytopathology · doi:10.1111/j.1365-2303.2010.00830.x · Cited by 27
Metadata
- Authors
- Jain, A., Verma, R. K., Tiwari, V., & Goel, M. M.
- Affiliations
- King George's Medical University (IN)
- Venue
- Acta Cytologica
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 49
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0001-5547 (ISSN-L)
- 1938-2650
- OpenAlex
- W2088974006
- Cited by
- 16
- References
- 20
- Citations by year
- 2025: 1 · 2021: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Cytologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphadenopathy Diagnosis and Analysis
- Keywords
- tuberculous lymphadenitis, dot-ELISA, IS6110 PCR, fine needle aspiration cytology, acid-fast bacillus smear, sensitivity and specificity, Mycobacterium tuberculosis detection
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Developing Countries, Enzyme-Linked Immunosorbent Assay, Humans, India, Lymphadenitis, Middle Aged, Mycobacterium tuberculosis, Prospective Studies, Sensitivity and Specificity, Tuberculosis, Lymph Node, Polymerase Chain Reaction, Biopsy, Fine-Needle
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