Cited by 32Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationRetinal Development and Disorders

Olig2 Lineage Cells Generate GABAergic Neurons in the Prethalamic Nuclei, Including the Zona Incerta, Ventral Lateral Geniculate Nucleus and Reticular Thalamic Nucleus

Inamura, Naoko, Ono, Katsuhiko, Takebayashi, Hirohide, Zalc, Bernard, Ikenaka, Kazuhiro·2011·Developmental Neuroscience

Abstract

Neuronal differentiation is a crucial event during neural development. Recent studies have characterized the development of the diencephalon; however, the origins of the primarily GABAergic prethalamic nuclei, including the zona incerta (ZI), ventral lateral geniculate nucleus (vLG) and reticular thalamic nucleus (RT), remain unclear. Here we characterize Olig2 lineage cells in the developing prethalamus using mice in which tamoxifen-induced recombination permanently labels Olig2-expressing cells. We show that GABAergic neurons in the prethalamic nuclei, including the RT, ZI and vLG, originate from prethalamic Olig2 lineage cells. Based on these data and on those derived from short-term lineage-tracing data using Olig3-lacZ mice and previous reports, we suggest that vLG cells originate from the ventricular zone of the thalamus, zona limitans intrathalamica and prethalamus.

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Crossref · 10.1159/000328974

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Authors
Inamura, N., Ono, K., Takebayashi, H., Zalc, B., & Ikenaka, K.
Affiliations
National Institute for Physiological Sciences (JP)
Venue
Developmental Neuroscience
Publisher
S. Karger AG
Published
2011
Volume
33
Issue
2
Pages
118-129
ISSN
  • 0378-5866 (ISSN-L)
  • 1421-9859
OpenAlex
W1991709766
Cited by
32
References
32
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 1
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23590237)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords
GABAergic neurons, zona incerta, ventral lateral geniculate nucleus, thalamic reticular nucleus, neuronal lineage tracing, neuronal differentiation, thalamus, zona limitans intrathalamica, ventricular zone
MeSH terms
Oligodendrocyte Transcription Factor 2, Animals, Cell Differentiation, Cell Movement, Female, Geniculate Bodies, Immunohistochemistry, Mice, Transgenic, Nerve Tissue Proteins, Stem Cells, Tamoxifen, In Situ Hybridization, Gene Expression Regulation, Developmental, Cell Lineage, Subthalamus, Ventral Thalamic Nuclei, Models, Animal, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, GABAergic Neurons

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