Olig2 Lineage Cells Generate GABAergic Neurons in the Prethalamic Nuclei, Including the Zona Incerta, Ventral Lateral Geniculate Nucleus and Reticular Thalamic Nucleus
Abstract
Neuronal differentiation is a crucial event during neural development. Recent studies have characterized the development of the diencephalon; however, the origins of the primarily GABAergic prethalamic nuclei, including the zona incerta (ZI), ventral lateral geniculate nucleus (vLG) and reticular thalamic nucleus (RT), remain unclear. Here we characterize Olig2 lineage cells in the developing prethalamus using mice in which tamoxifen-induced recombination permanently labels Olig2-expressing cells. We show that GABAergic neurons in the prethalamic nuclei, including the RT, ZI and vLG, originate from prethalamic Olig2 lineage cells. Based on these data and on those derived from short-term lineage-tracing data using Olig3-lacZ mice and previous reports, we suggest that vLG cells originate from the ventricular zone of the thalamus, zona limitans intrathalamica and prethalamus.
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Both RT and ZI neurons may have originated from the prethalamus or the zona limitans intrathalamica.
“Both RT and ZI neurons may have originated from the prethalamus or the zona limitans intrathalamica (ZLI)34–38.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [36]
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- Authors
- Inamura, N., Ono, K., Takebayashi, H., Zalc, B., & Ikenaka, K.
- Affiliations
- National Institute for Physiological Sciences (JP)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 33
- Issue
- 2
- Pages
- 118-129
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1991709766
- Cited by
- 32
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23590237)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- GABAergic neurons, zona incerta, ventral lateral geniculate nucleus, thalamic reticular nucleus, neuronal lineage tracing, neuronal differentiation, thalamus, zona limitans intrathalamica, ventricular zone
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Cell Differentiation, Cell Movement, Female, Geniculate Bodies, Immunohistochemistry, Mice, Transgenic, Nerve Tissue Proteins, Stem Cells, Tamoxifen, In Situ Hybridization, Gene Expression Regulation, Developmental, Cell Lineage, Subthalamus, Ventral Thalamic Nuclei, Models, Animal, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, GABAergic Neurons
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