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Severe Neonatal Hyperbilirubinemia and Kernicterus: Are These Still Problems in the Third Millennium?
Abstract
Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyperbilirubinemia has already developed have been formulated in several countries, but have not been successful in completely eliminating the problem. In this appraisal of the situation we review selected aspects of bilirubin encephalopathy and/or kernicterus. We highlight recent reports of severe hyperbilirubinemia and kernicterus, discuss some of the factors responsible for the continuing appearance of these conditions, and briefly review what can be done to decrease bilirubin-related morbidity and mortality to the minimum.
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Kernicterus and severe hyperbilirubinemia are strongly associated with G6PD deficiency and can be exacerbated by haemolytic agents such as menthol and naphthalene.
“Kernicterus and severe hyperbilirubinemia are strongly associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency [6, 16] and can be exacerbated by haemolytic agents such as menthol and naphthalene [17–20].”
From A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand–Myanmar Border (2017) · cites this paper as [6]
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Metadata
- Authors
- Kaplan, M., Bromiker, R., & Hammerman, C.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Venue
- Neonatology
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 100
- Issue
- 4
- Pages
- 354-362
- ISSN
- 1661-7800 (ISSN-L)
- 1661-7819
- OpenAlex
- W2047523700
- Cited by
- 114
- References
- 71
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 15 · 2014: 10 · 2013: 3 · 2012: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neonatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- neonatal hyperbilirubinemia, kernicterus, neonatal jaundice, hyperbilirubinemia treatment
- MeSH terms
- Developing Countries, Glucosephosphate Dehydrogenase Deficiency, Humans, Infant, Newborn, Infant, Premature, Kernicterus, Risk Factors, Infant, Very Low Birth Weight, Hyperbilirubinemia, Neonatal
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