EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency

Cited by (123)

Items 101–123 of 123

1. Design and screening of SGK1, Src dual inhibitors using pharmacophore models, molecular docking, and molecular dynamics simulation
   Chuance Sun, Lichuan Zhang, Chenglong Gao, Haoran Zhang, Rilei Yu, Congmin Kang · 2020 · New Journal of Chemistry
2. Increased expression and activation of serum- and glucocorticoid-inducible kinase-1 (SGK1) by cadmium in HK-2 renal proximal tubular epithelial cells
   Takamitsu Miyayama, Masato Matsuoka · 2014 · Environmental Toxicology and Pharmacology
3. PROTACs improve selectivity for targeted proteins
   Lihua Liu, Xian Guan, Jiezhen Zhuo, Xifeng Wu, Xin Han · 2025 · Acta Materia Medica
4. Adipose c-Jun NH2-terminal kinase promotes angiotensin II-induced and deoxycorticosterone acetate salt-induced hypertension and vascular dysfunction by inhibition of adiponectin production and activation of SGK1 in mice
   Jing Gan, Yaru Shi, Ruyi Zhao, Dan Li, Hua Jin, Maolan Wu, Zhen Liu, Xiaokun Li, Aimin Xu, Yulin Li et al. · 2023 · Journal of Hypertension
5. Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets
   Fei Yang, Changshun Chen, Rongjin Chen, Chenghui Yang, Zirui Liu, Lei Wen, Hefang Xiao, Bin Geng, Yayi Xia · 2025 · Biomolecules
6. Mechanism of ultrasound-guided renal parenchymal injection of MSCs for the treatment of chronic kidney disease: down-regulated SGK1 promotes M2 macrophage polarization
   Shanshan Wan, Daiyuan Tang, Zuozhang Yang, Yingqing Zeng, Long Hu, Liangyu Zhu, Chunjuan Xia, Fukai Bao, Changxing Ke, Jiaping Wang · 2026 · European journal of medical research
7. Epithelial Sodium Channels (ENaC)
   Chang Eun Song, Heping Ma, Douglas C. Eaton · 2020 · Physiology in health and disease
8. Serum and glucocorticoid-regulated kinase 1: A potential target for anticancer therapy
   Taj Mohammad, Md. Imtaiyaz Hassan · 2022 · Elsevier eBooks
9. Altered Plasma Membrane Lipid Composition in Hypertensive Neutrophils Impacts Epithelial Sodium Channel (ENaC) Endocytosis
   Yolanda Ríos-Medina, Pedro Rico-Chávez, Ivette Martínez‐Vieyra, Juan C. Durán–Álvarez, Mario Rodríguez‐Varela, Ruth Rincón-Heredia, César Augusto Sandino Reyes-López, Doris Cerecedo · 2024 · International Journal of Molecular Sciences
10. Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases
    Enrique Madruga, Alfonso García‐Rubia, Carlos Sanchez-Nuñez, Loreto Martínez-González, Ana María Fernández‐Escamilla, Isabel Lastres‐Becker, Carmen Gil, Ana Martı́nez · 2026 · Journal of Medicinal Chemistry
11. Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance
    Wei-Jie Zang, Yun-Long Ji, Chun-Wang Zhou, Xi-Wen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wan-Jiang Xue, Yi-Lin Hu · 2026 · Advancement of science
12. Possible divergence of serum- and glucocorticoid-inducible kinase function in ischemic brain injury
    Kōichi Inoue · 2016 · Neural Regeneration Research
13. Epithelial Sodium Channels (ENaCs)
    Tiffany L. Tai, He‐Ping Ma, Douglas C. Eaton · 2015 · Springer eBooks
14. Aldosterone regulation of protein kinase D and sodium reabsorption in the renal cortical collecting duct
    Sinéad Quinn · 2019
15. Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injury
    Catalina Sierra‐Ramos, Silvia Velázquez-García, Ayşe Gökçe Keşküş, Arianna Vastola-Mascolo, Ana Elena Rodríguez‐Rodríguez, Sergio Luis Lima, Guadalberto Hernández, Juan F. Navarro‐González, Esteban Porrini, Özlen Konu et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
16. Investigação genética por sequenciamento paralelo em larga escala do hiperaldosteronismo primário causado por hiperplasia adrenal cortical unilateral ou bilateral
    Marcela Rassi da Cruz · 2020
17. AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms
    Johnny Castillo Cabrera, Hong Dang, Zhigang Zhang, Jose L. Torres-Castillo, Kelin Li, Pengda Liu, Jeff Aubé, Blossom Damania, Robert S. Hagan, Albert S. Baldwin · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
18. Smooth Muscle Cell Specific Activity of SGK-1 Alters Aortic Stiffness and Abdominal Aortic Aneurysm Growth
    Matthew Anderson, Leilei Zhang, Mario Figueroa, Victoria Mattia, Alexander Rovner, Vinitha Uppalapati, Ying Xiong, Rupak D. Mukherjee, Jeffrey A. Jones, Jean Marie Ruddy · 2026 · Journal of Vascular Diseases
19. Small-molecule inhibitors of SGK1: Structural basis, structure-activity relationships, and therapeutic perspectives
    Jingjing Xie, Wu Wu, Guonian Zhu, Jinghong Xian, Liang Ouyang, Yiwen Zhang, Yuxi Wang · 2026 · European Journal of Medicinal Chemistry
20. SGK1 mediates TGF-β1-induced epithelial-mesenchymal transition and fibrosis in experimental bronchiolitis obliterans
    Hongwei Li, Li Zhao, Shihui Xu, Sixiang Tang, Junxing Lin, Yingjie Hu, Xiaowen Chen, Chengyu Lu, Dehui Chen · 2026 · iScience
21. BindingDB Entry 50015226: Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
    BindingDB · 2023 · UC San Diego
22. BindingDB Entry 50016839: VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.
    BindingDB · 2023 · UC San Diego
23. BindingDB Entry 5772: De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
    BindingDB · 2013 · UC San Diego