The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-Analysis
Open accessAbstract
Objective: To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia. Method: A systematic review and meta-analysis of randomized controlled trials were performed. Women who were randomized to low-dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included. The outcomes of interest were preterm preeclampsia (delivery <37 weeks) and term preeclampsia. Pooled relative risks (RR) with their 95% confidence intervals (CI) were computed. Results: The search identified 7,941 citations but only five trials on a combined total of 556 women fulfilled the inclusion criteria. When compared to controls, aspirin initiated ≤16 weeks of gestation was associated with a major reduction of the risk of preterm preeclampsia (RR 0.11, 95% CI 0.04–0.33) but had no significant effect on term preeclampsia (RR 0.98, 95% CI 0.42–2.33). Conclusion: Low-dose aspirin administrated at or before 16 weeks of gestation reduces the risk of preterm but not term preeclampsia.
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Cites
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
Cited by
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
Rolnik, D. L., Wright, D., Poon, L. C., O’Gorman, N., Syngelaki, A., de Paco Matallana, C., Akolekar, R., Cicero, S., Janga, D., Singh, M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1704559 · Cited by 2,287
Self-citationMagee, L. A., Brown, M. A., Hall, D. R., Gupte, S., Hennessy, A., Karumanchi, S. A., Kenny, L. C., McCarthy, F., Myers, J., Poon, L. C., et al. (2022) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.09.008 · Cited by 1,134
Bartsch, E., Medcalf, K. E., Park, A. L., & Ray, J. G. (2016) · BMJ · doi:10.1136/bmj.i1753 · Cited by 996
ACOG Committee Opinion No. 743: Low-Dose Aspirin Use During Pregnancy
(2018) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002708 · Cited by 711
Roberge, S., Nicolaides, K., Demers, S., Hyett, J., Chaillet, N., & Bujold, E. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.09.076 · Cited by 679
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Metadata
- Authors
- Roberge, S., Villa, P., Nicolaides, K., Giguère, Y., Vainio, M., Bakthi, A., Ebrashy, A., & Bujold, E.
- Venue
- Fetal Diagnosis and Therapy
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 31
- Issue
- 3
- Pages
- 141-146
- ISSN
- 1015-3837 (ISSN-L)
- 1421-9964
- OpenAlex
- W3022893079
- Cited by
- 381
- References
- 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-Analysis. https://app.cochat.ai/papers/10.1159/000336662
- The paper
- Roberge, S., Villa, P., Nicolaides, K., Giguère, Y., Vainio, M., Bakthi, A., Ebrashy, A., & Bujold, E. (2012). Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-Analysis. Fetal Diagnosis and Therapy. https://doi.org/10.1159/000336662
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
