The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Usefulness and Limitations of Sequential Serum Tryptase for the Diagnosis of Anaphylaxis in 102 Patients
Abstract
BACKGROUND: The diagnosis of anaphylaxis is based on clinical history since no reliable biological marker is currently available to confirm the diagnosis. OBJECTIVE: It was the aim of this study to determine sequential serum tryptase concentrations during anaphylaxis and to evaluate its potential as a diagnostic marker. METHODS: We performed a prospective study including patients with acute anaphylaxis (according to the National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network criteria) attending the emergency department. Demographic characteristics, anaphylactic triggers, specific risk factors, clinical characteristics and management of anaphylaxis were recorded. Serum tryptase was measured at 1-2 h (T1), 4-6 h (T2) and 12-24 h (T3) following onset of the episode and at basal conditions (TB). RESULTS: A total of 102 patients were included (63 females, mean age 47.4 ± 19.1 years). Tryptase concentration at T1 (19.3 ± 15.4 µg/l) was significantly higher than at T2, T3 and TB (all <11.4 µg/l; p < 0.0001). Importantly, tryptase was not raised in 36.3% of cases; furthermore, in 60.6% of these patients, no changes were observed in tryptase levels comparing T1 and TB (ΔT1-TB = 0). Tryptase was more frequently elevated in more severe anaphylaxis (p < 0.0001) and positively correlated with the grades of severity (p < 0.001, r = 0.49). Anaphylaxis was more severe and tryptase concentration higher when the causative agent was a drug compared to food, both at T1 (p = 0.045) and at TB (p = 0.019). Age and coronary risk factors were associated with more severe anaphylaxis (p = 0.001). CONCLUSION: Tryptase is a biomarker related to the severity of anaphylaxis. However, since its concentration remains unaltered in a considerable number of patients during acute anaphylaxis, there is a need for more reliable diagnostic biological tests.
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“Generally, the severity and magnitude of hypotension in anaphylaxis correlate with the height of tryptase [29,30].”
From Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders (2023) · cites this paper as [29]
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Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology
Muraro, A. M., Roberts, G. C., Worm, M., Bilò, M. B., Brockow, K., Fernández‐Rivas, M., Santos, A. F., Zolkipli, Z., Bellou, A., Beyer, K., et al. (2014) · Allergy · doi:10.1111/all.12437 · Cited by 1,052
EAACI guidelines: Anaphylaxis (2021 update)
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Metadata
- Authors
- Sala-Cunill, A., Cardona, V., Labrador-Horrillo, M., Luengo, O., Esteso, O., Garriga, T., Vicario, M., & Guilarte, M.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2012-09-25
- Volume
- 160
- Issue
- 2
- Pages
- 192-199
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- OpenAlex
- W2001266300
- Cited by
- 179
- References
- 32
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 15 · 2022: 20 · 2021: 14 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 16 · 2013: 8 · 2012: 1
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Archives of Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- anaphylaxis, serum tryptase, diagnostic biomarkers, anaphylaxis severity, drug-induced anaphylaxis, food-induced anaphylaxis, emergency department
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anaphylaxis, Female, Humans, Male, Middle Aged, Biomarkers, Tryptases, Young Adult
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