Cited by 16Stress Responses and CortisolNeuropeptides and Animal PhysiologyOpioid Use Disorder Treatment

Atrial natriuretic peptide, arginine vasopressin peptide and cortisol serum levels in opiate-dependent patients

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Glahn, Alexander, Heberlein, Annemarie, Dürsteler-MacFarland, Kenneth M., Lenz, Bernd, Frieling, Helge, Gröschl, Michael, Wiesbeck, Gerhard A., Kornhuber, Johannes +3 more·2013·Neuropsychobiology

Abstract

Preclinical studies suggest that chronic drug abuse profoundly alters stress-responsive systems. The best studied of the stress-responsive systems in humans is the hypothalamic-pituitary-adrenal (HPA) axis. Apart from cortisol, arginine vasopressin peptide (AVP), and atrial natriuretic peptide (ANP) are known to directly impact upon the HPA axis in addictive behavior. We investigated alterations in ANP, AVP and cortisol serum levels in opiate-dependent patients who received diacetylmorphine treatment within a structured opiate maintenance program. ANP serum levels were significantly increased in opiate-dependent patients as compared to healthy controls, whereas AVP and cortisol serum levels were reduced. The ANP, AVP and cortisol serum levels were not significantly associated with the psychometric dimensions of heroin craving. In conclusion, chronic drug abuse profoundly alters stress-responsive systems like the HPA axis. Alterations of AVP, ANP and cortisol appear to constitute an important component in the neurobiology of opiate-dependent patients.

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  1. [16]16. Holsboer F, Barden N: Antidepressants and HPA regulation. Endocr Rev 1996; 17: 187-205.

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Authors
Glahn, A., Heberlein, A., Dürsteler-MacFarland, K. M., Lenz, B., Frieling, H., Gröschl, M., Wiesbeck, G. A., Kornhuber, J., Bönsch, D., Bleich, S., & Hillemacher, T.
Affiliations
  • Medizinische Hochschule Hannover (DE)
  • Universitätsklinikum Erlangen (DE)
  • University of Basel (CH)
Venue
Neuropsychobiology
Publisher
S. Karger AG
Published
2013
Volume
67
Issue
2
Pages
111-115
ISSN
  • 0302-282X (ISSN-L)
  • 1423-0224
OpenAlex
W2083891802
Cited by
16
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
FWCI
0.76
Type
journal article
Language
en
Open access
Locations
  • Neuropsychobiology (publishedVersion)
  • PubMed (publishedVersion)
  • OPUS Repository (Kooperativer Bibliotheksverbund Berlin-Brandenburg) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
atrial natriuretic peptide, vasopressin, cortisol, opioid use disorder, heroin addiction, hypothalamic-pituitary-adrenal axis, stress response, heroin craving, neurobiology of addiction
MeSH terms
Adult, Arginine Vasopressin, Heroin, Enzyme-Linked Immunosorbent Assay, Fasting, Humans, Hydrocortisone, Male, Middle Aged, Opioid-Related Disorders, Narcotics, Atrial Natriuretic Factor, Psychometrics, Time Factors, Statistics, Nonparametric

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