Atrial natriuretic peptide, arginine vasopressin peptide and cortisol serum levels in opiate-dependent patients
Open accessAbstract
Preclinical studies suggest that chronic drug abuse profoundly alters stress-responsive systems. The best studied of the stress-responsive systems in humans is the hypothalamic-pituitary-adrenal (HPA) axis. Apart from cortisol, arginine vasopressin peptide (AVP), and atrial natriuretic peptide (ANP) are known to directly impact upon the HPA axis in addictive behavior. We investigated alterations in ANP, AVP and cortisol serum levels in opiate-dependent patients who received diacetylmorphine treatment within a structured opiate maintenance program. ANP serum levels were significantly increased in opiate-dependent patients as compared to healthy controls, whereas AVP and cortisol serum levels were reduced. The ANP, AVP and cortisol serum levels were not significantly associated with the psychometric dimensions of heroin craving. In conclusion, chronic drug abuse profoundly alters stress-responsive systems like the HPA axis. Alterations of AVP, ANP and cortisol appear to constitute an important component in the neurobiology of opiate-dependent patients.
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Opiate-dependent patients on diacetylmorphine (heroin) maintenance treatment had reduced AVP levels compared with controls.
“Finally, opiate-dependent patients on diacetylmorphine (heroin) maintenance treatment had reduced AVP levels compared with controls (181).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [181]
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- Authors
- Glahn, A., Heberlein, A., Dürsteler-MacFarland, K. M., Lenz, B., Frieling, H., Gröschl, M., Wiesbeck, G. A., Kornhuber, J., Bönsch, D., Bleich, S., & Hillemacher, T.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Universitätsklinikum Erlangen (DE)
- University of Basel (CH)
- ORCID
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2013
- Volume
- 67
- Issue
- 2
- Pages
- 111-115
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2083891802
- Semantic Scholar
- 71b6d962301706a2017192a38548370a7c41bae1
- Cited by
- 16
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- nbn-resolving.org
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- OPUS Repository (Kooperativer Bibliotheksverbund Berlin-Brandenburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- atrial natriuretic peptide, vasopressin, cortisol, opioid use disorder, heroin addiction, hypothalamic-pituitary-adrenal axis, stress response, heroin craving, neurobiology of addiction
- MeSH terms
- Adult, Arginine Vasopressin, Heroin, Enzyme-Linked Immunosorbent Assay, Fasting, Humans, Hydrocortisone, Male, Middle Aged, Opioid-Related Disorders, Narcotics, Atrial Natriuretic Factor, Psychometrics, Time Factors, Statistics, Nonparametric
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