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Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease

Hsieh, Sharpley, Schubert, Samantha, Hoon, Christopher, Mioshi, Eneida, Hodges, John R.·2013·Dementia and Geriatric Cognitive Disorders

Abstract

Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.

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Metadata

Authors
Hsieh, S., Schubert, S., Hoon, C., Mioshi, E., & Hodges, J. R.
Venue
Dementia and Geriatric Cognitive Disorders
Publisher
S. Karger AG
Published
2013
Volume
36
Issue
3-4
Pages
242-250
ISSN
  • 1420-8008 (ISSN-L)
  • 1421-9824
OpenAlex
W1999887188
Cited by
973
References
9
FWCI
18.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease. https://app.cochat.ai/papers/10.1159/000351671
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Hsieh, S., Schubert, S., Hoon, C., Mioshi, E., & Hodges, J. R. (2013). Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. https://doi.org/10.1159/000351671

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.