Cited by 103Mesenchymal stem cell researchTelomeres, Telomerase, and SenescencePluripotent Stem Cells Research

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review

Yu, Kyung-Rok, Kang, Kyung-Sun·2013·Gerontology

Open this paper in CoChat — free account

Abstract

Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because MSCs have many advantages for cell therapy, including multilineage differentiation, homing, immune modulation and wound-healing effects. However, as the aging of MSCs leads to an age-associated decline in their number and function, it is important to clarify the age-associated factors and regulatory mechanism associated with the MSC aging process. In this review, we amass and discuss the recent data related to age-associated genes in MSCs. In particular, the activities of epigenetic regulatory factors, including histone acetylase and DNA methyltransferase, modulate gene expression and crosstalk with each other during the MSC senescence process. p16 INK4A and high-mobility group A2 play important age-associated roles in the regulation of MSC stemness, and lamin A- and prelamin A-dependent nuclear abnormalities have significant biological relevance in MSC aging. Taken together, the information described here, including the epigenetic regulatory factors, transcription factors and cell signaling, could be used toward the development of treatments for MSC aging and related defects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1159/000353857

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106
Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model
Muraglia, A., Cancedda, R., & Quarto, R. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.7.1161 · Cited by 1,025
Cellular senescence and tumor suppressor gene p16
Rayess, H., Wang, M. B., & Srivatsan, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27316 · Cited by 825
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
Grosschedl, R., Giese, K., & Pagel, J. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90232-1 · Cited by 814
Genomic instability in laminopathy-based premature aging
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650
Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
Nishino, J., Kim, I., Chada, K. K., & Morrison, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.017 · Cited by 638
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
Scaffidi, P., & Misteli, T. (2008) · Nature Cell Biology · doi:10.1038/ncb1708 · Cited by 518
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration
Kode, J., Mukherjee, S., Joglekar, M. V., & Hardikar, A. A. (2009) · Cytotherapy · doi:10.1080/14653240903080367 · Cited by 394
DNA damage checkpoints in stem cells, ageing and cancer
Sperka, T., Wang, J., & Rudolph, K. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3420 · Cited by 393

Flagged first, then by citations

Show all 29 references

Sorted by citations

Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges
Bagno, L., Hatzistergos, K. E., Balkan, W., & Hare, J. M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.009 · Cited by 349
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.4 · Cited by 335
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
Costa, L. A., Eiró, N., Fraile, M., González, L. O., Saá, J., García-Portabella, P., Vega, B., Schneider, J., & Vizoso, F. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03600-0 · Cited by 328
Senescence of mesenchymal stem cells (Review)
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., & Bao, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2912 · Cited by 280
Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives
Lee, W., & Wang, B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.03.005 · Cited by 218
BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling
Zuo, R. M., Liu, M., Wang, Y., Li, J., Wang, W., Wu, J., Sun, C., Li, B., Wang, Z., Lan, W., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1121-9 · Cited by 190
Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine
Miceli, V., Bulati, M., Iannolo, G., Zito, G., Gallo, A., & Conaldi, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020763 · Cited by 182
Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process
Salminen, A., Kauppinen, A., Hiltunen, M. O., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.05.004 · Cited by 145
Age-related cerebral small vessel disease and inflammaging
Li, T., Huang, Y., Cai, W., Chen, X., Men, X., Lü, T., Wu, A., & Lu, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03137-x · Cited by 128
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Zhu, Y., Ge, J., Huang, C., Liu, H., & Jiang, H. (2021) · Theranostics · doi:10.7150/thno.46436 · Cited by 126
Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging
Neri, S., & Borzì, R. M. (2020) · Biomolecules · doi:10.3390/biom10020340 · Cited by 126
Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities
Vizoso, F. J., Eiró, N., Costa, L. A., Esparza, P., Landín, M., Díaz‐Rodríguez, P., Schneider, J., & Pérez-Fernández, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153738 · Cited by 107
Umbilical Cord Mesenchymal Stromal Cells Affected by Gestational Diabetes Mellitus Display Premature Aging and Mitochondrial Dysfunction
Kim, J., Piao, Y., Pak, Y. K., Chung, D.-H., Han, Y. M., Hong, J. S., Jun, E. J., Shim, J., Choi, J., & Kim, C. J. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0349 · Cited by 105
New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy
Wacleche, V. S., Goulet, J.-P., Gosselin, A., Monteiro, P., Soudeyns, H., Fromentin, R., Jenabian, M.-A., Vartanian, S. M., Deeks, S. G., Chomont, N., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0293-6 · Cited by 103
Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues
Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 91
Curcumin Affects Adipose Tissue-Derived Mesenchymal Stem Cell Aging Through TERT Gene Expression
Pirmoradi, S., Fathi, E., Farahzadi, R., Pilehvar‐Soltanahmadi, Y., & Zarghami, N. (2017) · Drug Research · doi:10.1055/s-0043-119635 · Cited by 86
Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells
Legzdina, D., Romanauska, A., Nikulshin, S., Kozlovska, T., & Bērziņš, U. (2016) · International Journal of Stem Cells · doi:10.15283/ijsc.2016.9.1.124 · Cited by 82
Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/MTOR Signaling
Zhang, D., Yan, B., Yu, S., Zhang, C., Wang, B., Wang, Y., Wang, J., Yuan, Z., Zhang, L., & Pan, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/867293 · Cited by 75
Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01744-1 · Cited by 76
Effect of low oxygen tension on the biological characteristics of human bone marrow mesenchymal stem cells
Kim, D. S., Ko, Y. J., Lee, M. W., Park, H. J., Park, Y. J., Kim, D.-I., Sung, K. W., Koo, H. H., & Yoo, K. H. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0733-1 · Cited by 78
Impact of Mesenchymal Stem Cell Senescence on Inflammaging
Lee, B.-C., & Yu, K. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.2.291 · Cited by 72
Self-citation
The Impact of Epigenetics on Mesenchymal Stem Cell Biology
Özkul, Y., & Galderisi, U. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25371 · Cited by 69
A p38 MAPK-Mediated Alteration of COX-2/PGE2 Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging
Yu, K., Lee, J. Y., Kim, H., Hong, I., Choi, S. W., Seo, Y., Kang, I., Kim, J.-J., Lee, B., Lee, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102426 · Cited by 67
Self-citation
Mesenchymal Stem Cell Therapy for Aging Frailty
Schulman, I. H., Balkan, W., & Hare, J. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00108 · Cited by 65
Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling
Yang, M., Teng, S., Ma, C., Yu, Y., Wang, P., & Yi, C. (2018) · Cytotechnology · doi:10.1007/s10616-018-0220-x · Cited by 66
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18
Lee, S., Yu, K., Ryu, Y.-S., Oh, Y. S., Hong, I., Kim, H.-S., Lee, J. Y., Kim, S., Seo, K., & Kang, K. (2014) · AGE · doi:10.1007/s11357-014-9724-2 · Cited by 59
Self-citation
KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization
Huang, B., Wang, B., Lee, W., Kin Pong, U., Leung, K. T., Li, X., Liu, Z., Chen, R., Lin, J., Tsang, L. L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.041 · Cited by 54
Zinc sulfate contributes to promote telomere length extension via increasing telomerase gene expression, telomerase activity and change in the TERT gene promoter CpG island methylation status of human adipose-derived mesenchymal stem cells
Farahzadi, R., Fathi, E., Mesbah‐Namin, S. A., & Zarghami, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188052 · Cited by 52
Retracted
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Toraño, E. G., Bayón, G. F., del Real, Á., Sierra, M., García, M. G., Carella, A., Belmonte, T., Urdinguio, R. G., Cubillo, I., Garcı́a-Castro, J., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0966-x · Cited by 49
Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion
Truong, N. C., Bui, K. H.-T., & Pham, P. V. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_235 · Cited by 50
Research progress on sirtuins family members and cell senescence
Wang, T., Wang, Y., Liu, L., Jiang, Z., Li, X., Tong, R., He, J., & Shi, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112207 · Cited by 48
Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island methylation status of adipose tissue-derived mesenchymal stem cells
Farahzadi, R., Fathi, E., Mesbah‐Namin, S. A., & Zarghami, N. (2018) · Tissue and Cell · doi:10.1016/j.tice.2018.08.012 · Cited by 47
Anti-aging effect of β-carotene through regulating the KAT7-P15 signaling axis, inflammation and oxidative stress process
Zheng, W., Wang, X., Li, Y., Qin, J., Zhou, T., Li, D., Xu, Y., Cheng, X., Xiong, Y., & Chen, Z. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00389-7 · Cited by 45
Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration
Han, N., Zhang, W., Fang, X., Li, Q.-C., & Pi, W. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.343889 · Cited by 45
Immunoevasive Pericytes From Human Pluripotent Stem Cells Preferentially Modulate Induction of Allogeneic Regulatory T Cells
Domev, H., Milkov, I., Itskovitz‐Eldor, J., & Dar, A. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0097 · Cited by 43
Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment
Scassellati, C., Ciani, M., Galoforo, A. C., Zanardini, R., Bonvicini, C., & Geroldi, C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111210 · Cited by 45
GHK and DNA: Resetting the human genome to health
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39
Identification of senescent cells in multipotent mesenchymal stromal cell cultures: Current methods and future directions
Zhai, W., Yong, D., El‐Jawhari, J. J., CUTHBERT, R., McGonagle, D., Naing, M. W., & Jones, E. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.05.001 · Cited by 41
L-carnitine significantly decreased aging of rat adipose tissue-derived mesenchymal stem cells
Mobarak, H., Fathi, E., Farahzadi, R., Zarghami, N., & Javanmardi, S. (2016) · Veterinary Research Communications · doi:10.1007/s11259-016-9670-9 · Cited by 38
Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss
Zhang, L., Qi, M., Chen, J., Zhao, J., Li, L., Hu, J.-C. E., Jin, Y. J., & Liu, W. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01785-6 · Cited by 37
Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy
Fu, H., Chuang, I., Yang, Y.-C., Chuang, P.-C., Lin, H., Ou, Y., Chien, C.-C. C., Huang, H., & Kang, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092541 · Cited by 35
Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors
Rossi, F., Paola, A. D., Pota, E., Argenziano, M., Pinto, D., Marrapodi, M. M., Leva, C. D., Martino, M. D., & Tortora, C. (2021) · Cancers · doi:10.3390/cancers13194933 · Cited by 37
p53 and its mutants on the slippery road from stemness to carcinogenesis
Molchadsky, A., & Rotter, V. (2017) · Carcinogenesis · doi:10.1093/carcin/bgw092 · Cited by 30
Epigenetic changes in umbilical cord mesenchymal stromal cells upon stimulation and culture expansion
de Witte, S. F. H., Peters, F. S., Merino, A. M., Korevaar, S. S., van Meurs, J. B. J., O’Flynn, L., Elliman, S. J., Newsome, P. N., Boer, K., Baan, C. C., et al. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.05.005 · Cited by 29
Use of Statins to Augment Progenitor Cell Function in Preclinical and Clinical Studies of Regenerative Therapy: a Systematic Review
Park, A., Barrera‐Ramirez, J., Ranasinghe, I., Pilon, S., Sy, R. G., Fergusson, D. A., & Allan, D. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9647-7 · Cited by 28
GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells
Kostyuk, S. V., Смирнова, Т. А., Kameneva, L. V., Porokhovnik, L. N., Speranskij, A., Ershova, E. S., Stukalov, S., Izhevskaya, V. L., & Veiko, N. N. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/782123 · Cited by 28
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Yang, X. F., Wang, Y., Rovella, V., Candi, E., Jia, W. P., Bernassola, F., Bove, P., Piacentini, M., Scimeca, M., Sica, G. S., et al. (2023) · Biology Direct · doi:10.1186/s13062-023-00394-6 · Cited by 28
“Ins” and “Outs” of mesenchymal stem cell osteogenesis in regenerative medicine
Yamaguchi, D. T. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.94 · Cited by 29
Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity
Kang, J. Y., Oh, M., Joo, H., Park, H. S., Chae, D., Kim, J., Lee, H., Oh, I., & Yu, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092913 · Cited by 28
Self-citation
Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34posHematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction
Moslem, M., Eberle, I., Weber, I., Henschler, R., & Cantz, T. (2015) · Stem Cells International · doi:10.1155/2015/843058 · Cited by 25
Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
Bellotti, C., Capanni, C., Lattanzi, G., Donati, D. M., Lucarelli, E., & Duchi, S. (2016) · SpringerPlus · doi:10.1186/s40064-016-3091-7 · Cited by 25
Mesenchymal Stem Cell Senescence and Osteogenesis
Tjempakasari, A., Suroto, H., & Santoso, D. (2021) · Medicina · doi:10.3390/medicina58010061 · Cited by 25
Cell culture density affects the proliferation activity of human adipose tissue stem cells
Kim, D. S., Lee, M. W., Ko, Y. J., Chun, Y. H., Kim, H. J., Sung, K. W., Koo, H. H., & Yoo, K. H. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3158 · Cited by 23
Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function
Wang, D., Liu, N., Xie, Y., Song, B., Kong, S., & Sun, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15081 · Cited by 22
Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer
Armbruster, N. S., Krieg, J., Weißenberger, M., Scheller, C., & Steinert, A. F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00255 · Cited by 21
Heart Failure and Adipose Mesenchymal Stem Cells
Matsushita, K. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.003 · Cited by 21
Age-Related Alterations Affecting the Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stromal Cells in an Equine Model
Mazzotti, E., Teti, G., Falconi, M., Chiarini, F., Barboni, B., Mazzotti, A., & Muttini, A. (2019) · Cells · doi:10.3390/cells8101116 · Cited by 21
Age-Related Alterations in Mesenchymal Stem Cell Function: Understanding Mechanisms and Seeking Opportunities to Bypass the Cellular Aging
Rasouli, M., Naeimzadeh, Y., Hashemi, N., & Hosseinzadeh, S. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230113144016 · Cited by 20
Understanding lamin proteins and their roles in aging and cardiovascular diseases
Jiang, Y., & Ji, J. Y. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.026 · Cited by 18
Effects of maternal age on the expression of mesenchymal stem cell markers in the components of human umbilical cord
Alrefaei, G. I., Ayuob, N. N., Ali, S. S., & Alkarim, S. (2015) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2015.0022 · Cited by 20
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells
Lazzarini, R., Caffarini, M., Tang, H., Cerqueni, G., Pellegrino, P., Monsurrò, V., Primio, R. D., & Orciani, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.02.014 · Cited by 14
Roles of Microenvironment on Mesenchymal Stem Cells Therapy for Osteoarthritis
Zhang, H., Jin, C., Hua, J., Chen, Z., Gao, W., Xu, W., Zhou, L., & Shan, L. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s475617 · Cited by 14
Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton's Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway
Park, H. S., Oh, M., Lee, J. W., Chae, D., Joo, H., Kang, J. Y., An, H. B., Yu, A., Park, J. H., Yoo, H. M., et al. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc21178 · Cited by 13
Self-citation
Methods and insights from the characterization of osteoprogenitor cells of bats (Mammalia: Chiroptera)
Ball, H. C., Moussa, F. M., Mbimba, T., Orman, R., Safadi, F. F., & Cooper, L. N. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.05.009 · Cited by 14
Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop
Baek, S. J., Hammock, B. D., Hwang, I. K., Li, Q. X., Moustaïd‐Moussa, N., Park, Y., Safe, S. H., Suh, N., Yi, S.-S., Zeldin, D. C., et al. (2021) · Nutrients · doi:10.3390/nu13061881 · Cited by 15
Maternal and neonatal factors’ effects on wharton's jelly mesenchymal stem cell yield
Mahmoud, R., Bassiouny, M. R., Badawy, A., Darwish, A., Yahia, S., & El-Tantawy, N. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-72386-z · Cited by 12
Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice
Li, M., Guo, K., Adachi, Y., & Ikehara, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020183 · Cited by 12
The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells
Jeong, Y.-H., Oh, H., Lee, M. R., Kim, C., Joo, C., Park, S., Song, Y.-H., Kang, C., Chung, H., Kang, S., et al. (2018) · Polymers · doi:10.3390/polym10080839 · Cited by 12
Senescence‐induced immunophenotype, gene expression and electrophysiology changes in human amniocytes
Airini, R., Iordache, F., Alexandru, D., Savu, L., Epureanu, F. B., Mihailescu, D. F., Amuzescu, B. P., & Maniu, H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14495 · Cited by 12
Mesenchymal Stromal Cell Therapy
Neofytou, E. A., Deuse, T., Beygui, R. E., & Schrepfer, S. (2015) · Transplantation · doi:10.1097/tp.0000000000000734 · Cited by 12
Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model
Kim, J. Y., Kim, S. H., Seok, J., Bae, S. H., Hwang, S. G., & Kim, G. J. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.01.017 · Cited by 10
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway
Bie, Y., Gu, P., Chen, Y., Zhou, X., Tian, Y.-G., Yang, Q. Z., Li, H., Lin, X., Guan, Y.-H., Lin, T., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1820-8 · Cited by 9
Does the maternal age affect the mesenchymal stem cell markers and gene expression in the human placenta? What is the evidence?
Alrefaei, G. I., Alkarim, S., Ayuob, N. N., & Ali, S. S. (2015) · Tissue and Cell · doi:10.1016/j.tice.2015.05.005 · Cited by 10
The positive effect of chick embryo and nutrient mixture on bone marrow- derived mesenchymal stem cells from aging rats
Ma, J., Guo, Y., Hu, J., Pan, Y., Xia, Q., Wang, H., & Li, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-25563-w · Cited by 9
The path to biotechnological singularity: Current breakthroughs and outlook
Wen, Z., Yang, D., Yang, Y., Hu, J., Parviainen, A., Chen, X., Li, Q., VanDeusen, E. A., Ma, J., & Tay, F. R. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108667 · Cited by 7
Osteoporosis and Mechanisms of Skeletal Aging
Glowacki, J., & Vokes, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_10 · Cited by 6
Unique Aspects of the Design of Phase I/II Clinical Trials of Stem Cell Therapy
Schulman, I. H., Balkan, W., Saltzman, R., DaFonseca, D., Caceres, L. V., Delgado, C., Pujol, M. V., Ramdas, K. N., Tovar, J. A., Vidro-Casiano, M., et al. (2018) · InTech eBooks · doi:10.5772/intechopen.72949 · Cited by 6
Epigenetics and Aging
Saldanha, S. N., & Watanabe, L. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800957-4.00018-7 · Cited by 6
Somatic stem cell aging and malignant transformation – impact on therapeutic application
Kuniaková, M., Oravcová, L., Varchulová-Nováková, Z., Viglaska, D., & Danišovič, Ľ. (2015) · Cellular & Molecular Biology Letters · doi:10.1515/cmble-2015-0045 · Cited by 5
Comparative analysis of molecular activity in dermal mesenchymal stem cells from different passages
Li, X., Li, J., Zhao, X., Wang, Q., Yang, X., Cheng, Y., Zhou, M., Wang, G., Dang, E., Yang, X., et al. (2017) · Cell and Tissue Banking · doi:10.1007/s10561-017-9672-z · Cited by 4
Mesenchymal Stromal Cells as a Therapeutic Intervention
Schulman, I. H., & Hare, J. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78586 · Cited by 4
Effect of Mother’s Age and Pathology on Functional Behavior of Amniotic Mesenchymal Stromal Cells—Hints for Bone Regeneration
Matteo, M., Beccia, E., Carbone, A., Castellani, S., Milillo, L., Lauritano, D., Gioia, S. D., Angiolillo, A., & Conese, M. (2019) · Applied Sciences · doi:10.3390/app9173471 · Cited by 2
Aging of Human Mesenchymal Stem Cells
Lepperdinger, G., & Reitinger, S. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_11 · Cited by 1
A New Cell Stem Concept for Pelvic Floor Disorders Prevention and Treatment – Endometrial Mesenchymal Stem Cells
Russu, M. C. (2022) · Biochemistry · doi:10.5772/intechopen.108010 · Cited by 2
Stem Cells and Aging
Perdiguero, E., García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00138-3 · Cited by 1
Stem Cells and Aging
Perdiguero, E., García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30115-8 · Cited by 1
Ageing in the mammalian brain
Khojah, S. M. (2015) · Enlighten: Theses (The University of Glasgow)
Novel Way to Isolate Adipose Derive Mesenchymal Stem Cells & Its Future Clinical Applications in Obesity
Chakraborty, E., & Shaikh, N. R. (2014)
Allogeneic versus Autologous Source
Taldone, S. N., Schulman, I. H., Balkan, W., & Hare, J. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801888-0.00012-6
Comparison of biological characteristic and osteogenic differentiation between bone marrow and adipose mesenchymal stem cell in various age group
Chandra, W. (2016) · International Journal of PharmTech Research
CCR5 deficiency in aged mice causes a decrease in bone mass
Oh, E.-J., Zang, Y., Kim, J.-W., Lee, M. N., Song, J. H., Oh, S., Kwon, S. H., Yang, J., & Koh, J. (2019) · International Journal of Oral Biology · doi:10.11620/ijob.2019.44.4.173
A Comparative Analysis of Wound Healing Potential, Cell Viability and Morphology of Normal and Gestational Diabetic Affected Wharton’s Jelly Derived Mesenchymal Stem Cells
Rasheed, N., Waseem, B., Haneef, K., Usman, S., Sadiq, M., Urooj, T., Tarique, S., & Zeha, D. (2021) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/20201012081021
The CCL7-CCL2-CCR2 Axis Regulates Age-Related Alterations in ADSCsPreprint
Li, K., Shi, G., Lei, X., Huang, Y., Li, X., Bai, L., & Qin, C. (2021) · Research Square · doi:10.21203/rs.3.rs-390571/v1
Edible Bird’s Nest Extract Reduced Expression of Senescence Markers in Bone Marrow Mesenchymal Stem Cells
Elfita, L., Wientarsih, I., Sajuthi, D., Bachtiar, I., & Darusman, H. S. (2021) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.8.1.19-26.2021
Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function
Semedo, P., Pereira, G., de Almeida, D. C., & Câmara, N. O. S. (2023) · Biochemistry · doi:10.5772/intechopen.109273
A New Era for a New Concept: Endometrial/Menstrual Mesenchymal Stem Cells and Their Secretome for Prevention and Treatment of Pelvic Floor Disorders
Russu, M. C. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.114088
Studies on Endometrial Mesenchymal Stem Cells in Female Regenerative Pelvic Floor Medicine
Russu, M. C. (2025) · Obstetrics and gynecology. · doi:10.5772/intechopen.1010815
Additional file 2 of Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12457301
Additional file 3 of Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12457307
Additional file 1 of Anti-aging effect of β-carotene through regulating the KAT7-P15 signaling axis, inflammation and oxidative stress process
Zheng, W., Xu, W., Li, Y., Qin, J., Zhou, T., Li, D., Xu, Y., Cheng, X., Xiong, Y., & Chen, Z. (2022) · Figshare · doi:10.6084/m9.figshare.21301422

Authors: Yu, K.-R., & Kang, K.-S.
Affiliations: Seoul National University (KR)
ORCID: Yu, Kyung-Rok
Kang, Kyung-Sun
Venue: Gerontology
Publisher: S. Karger AG
Published: 2013
Volume: 59
Issue: 6
Pages: 557-563
ISSN: 0304-324X (ISSN-L)
1423-0003
DOI: 10.1159/000353857
OpenAlex: W2031921408
Cited by: 103
References: 29
Citations by year: 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 14 · 2014: 8
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Gerontology (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Seoul National University
Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: mesenchymal stem cells, stem cell aging, epigenetic regulation, histone acetyltransferase, DNA methyltransferases, p16INK4a, HMGA2, lamin A, prelamin A, nuclear abnormalities, stemness, cell therapy
MeSH terms: Aging, Animals, Gene Expression Regulation, Histone Deacetylases, Humans, DNA Modification Methylases, Signal Transduction, Genes, p16, HMGA2 Protein, Lamin Type A, Epigenesis, Genetic, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks