Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/MTOR Signaling
Open accessAbstract
Increasing evidences indicate that reactive oxygen species are the main factor promoting stem cell aging. Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in organ and cellular aging. However, the potential for CoQ10 to protect stem cell aging has not been fully evaluated, and the mechanisms of cell senescence inhibited by CoQ10 are still poorly understood. Our previous study had indicated that D-galactose (D-gal) can remarkably induce mesenchymal stem cell (MSC) aging through promoting intracellular ROS generation. In this study, we showed that CoQ10 could significantly inhibit MSC aging induced by D-gal. Moreover, in the CoQ10 group, the expression of p-Akt and p-mTOR was clearly reduced compared with that in the D-gal group. However, after Akt activating by CA-Akt plasmid, the senescence-cell number in the CoQ10 group was significantly higher than that in the control group. These results indicated that CoQ10 could inhibit D-gal-induced MSC aging through the Akt/mTOR signaling.
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Coenzyme Q10, SkQ1, mitoquinone and methylene blue are among mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied.
“Coenzyme Q10 (CoQ10), SkQ1 (a.k.a. visomitin), mitoquinone (MitoQ) and methylene blue are among the mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied (Table 1 and Table 2) [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [64]
Some in vitro studies indicate that CoQ10 can protect stem cells from OS-induced aging by influencing the Akt/mTOR signalling pathway, therefore preserving their proliferative balance.
“In this respect, some in vitro studies indicate that CoQ10 can protect stem cells from OS-induced aging by influencing the Akt/mTOR signalling pathway, therefore preserving their proliferative balance [64].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [64]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Huo, J., Xu, Z., Hosoe, K., Kubo, H., Miyahara, H., Dai, J., Mori, M., Sawashita, J., & Higuchi, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3181759 · Cited by 87 · see citing works
- Authors
- Zhang, D., Yan, B., Yu, S., Zhang, C., Wang, B., Wang, Y., Wang, J., Yuan, Z., Zhang, L., & Pan, J.
- Affiliations
- Zhejiang University (CN)
- Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China
- Corresponding author
- Pan, Jianping
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-10
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4348608
- OpenAlex
- W2075734310
- Cited by
- 75
- References
- 68
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 4
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81302806, LY13H160030, LQ12H31001, LY14C090001, 2012KYB066, 2013KYA151, 20130633B33, 20130633B34)
- Natural Science Foundation of Zhejiang Province (81302806, LY13H160030, LQ12H31001, LY14C090001, 2012KYB066, 2013KYA151, 20130633B33, 20130633B34)
- Science Research Foundation of Zhejiang Health Bureau (81302806, LY13H160030, LQ12H31001, LY14C090001, 2012KYB066, 2013KYA151, 20130633B33, 20130633B34)
- Scientific and Technological Developing Scheme of Hangzhou (81302806, LY13H160030, LQ12H31001, LY14C090001, 2012KYB066, 2013KYA151, 20130633B33, 20130633B34)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- coenzyme Q10, mesenchymal stem cells, cellular senescence, D-galactose-induced aging, Akt/mTOR signaling, reactive oxygen species, stem cell aging
- MeSH terms
- Animals, Bone Marrow Cells, Cells, Cultured, Galactose, Mitochondria, Phosphorylation, Ubiquinone, Signal Transduction, Tumor Suppressor Protein p53, Cellular Senescence, Rats, Sprague-Dawley, Reactive Oxygen Species, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Proto-Oncogene Proteins c-akt, Rats, TOR Serine-Threonine Kinases, Mesenchymal Stem Cells
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