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Cited by 17Growth Hormone and Insulin-like Growth FactorsGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesHypothalamic control of reproductive hormones

Height gain in Ullrich-Turner syndrome after early and late growth hormone treatment start: results from a large retrospective German study and potential basis for an individualized treatment approach

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Bettendorf, Markus, Inta, Ioana M., Doerr, Helmuth G., Hauffa, Berthold P., Mehls, Otto, Ranke, Michael B.·2013·Hormone Research in Paediatrics
DOI 10.1159/000356045
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Abstract

BACKGROUND: Ullrich-Turner syndrome (UTS) girls often present with short stature in adolescence to the endocrinologist when the efficacy of growth hormone (GH) to improve growth remains unknown and parameters to estimate individual GH responsiveness have yet to be determined. OBJECTIVE: Retrospective evaluation of adult height (AH) and predicted adult height at GH start (descriptive model of Ranke, Model PredAH) in early and late GH-treated German UTS patients. SUBJECTS/METHODS: 313 patients treated with GH, early [chronological age (CA) at GH start <12 years, n = 259] or late (CA at GH start ≥12 years, n = 54) who reached AH were selected from KIGS (Pfizer International Growth Database). RESULTS: AH (152.5 ± 5.9 vs. 151.1 ± 5.4 cm, p = n.s.) after GH treatment for 7.5 ± 2.12 years (GH start early) and for 5.2 ± 1.2 years (GH start late) were similar (p = n.s.) as Model PredAH (155.7 ± 4.8 vs. 154.7 ± 4.8 cm; p = n.s.) but higher (p < 0.001) than projected adult height (Ranke, ProjAH; 148.2 ± 5.5 vs. 145.2 ± 6.7 cm; p = 0.001). Total height gain over ProjAH was 4.3 ± 4.6 cm (GH start early) and 5.8 ± 4.7 cm (GH start late, p = 0.021), respectively. CONCLUSIONS: GH may improve AH in UTS patients even when started late. The individual growth response could be estimated by the descriptive Model PredAH independent of age at treatment start.

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Research works printed but not linked: 2

  1. Simm D, Degenhardt K, Gerdemann C, Völkl TM, Rauch A, Dörr HG: Chronological age of patients with Turner syndrome at diagnosis. Klin Paediatr 2008; 220: 16-20.
  2. Ranke MB, Lindberg A: Turner syndrome within KIGS including an analysis of 1,146 patients grown to near adult height; in Ranke MB, Price DA, Reiter EO (eds): Growth Hor- mone Therapy Pediatrics -20 Years of KIGS. Basel, Karger, 2007, pp 332-339.

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Authors
Bettendorf, M., Inta, I. M., Doerr, H. G., Hauffa, B. P., Mehls, O., & Ranke, M. B.
Affiliations
  • Heidelberg University (DE)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University of Duisburg-Essen (DE)
  • University Children's Hospital Tübingen (DE)
ORCID
Venue
Hormone Research in Paediatrics
Publisher
S. Karger AG
Published
2013
Volume
80
Issue
5
Pages
356-362
ISSN
  • 1663-2818 (ISSN-L)
  • 1663-2826
DOI
10.1159/000356045
OpenAlex
W2019867349
Cited by
17
References
43
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Hormone Research in Paediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • OPUS Repository (Kooperativer Bibliotheksverbund Berlin-Brandenburg) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
Ullrich-Turner syndrome, growth hormone therapy, adult height, short stature, predicted adult height, growth response, personalized treatment
MeSH terms
Adolescent, Age Factors, Body Height, Child, Child, Preschool, Female, Germany, Humans, Retrospective Studies, Turner Syndrome, Human Growth Hormone

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