Cited by 177Gut microbiota and healthGastrointestinal motility and disordersDiabetes Treatment and Management

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Short-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release

Kaji, Izumi, Karaki, Shin-ichiro, Kuwahara, Atsukazu·2014·Digestion

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Abstract

Background: Gut microbiota affects host homeostasis and dysbiosis causes host diseases. Therefore, uncovering the sensing mechanism of bacterial metabolites such as short-chain fatty acid (SCFA) may help us to understand the host-microbiota interaction both in physiological and nonphysiological conditions. Summary: The colonic lumen is continually exposed to many kinds of chemicals, including beneficial and harmful compounds that are produced by gut microbiota in addition to ingested nutrients. In the mammalian colon SCFAs such as acetate, propionate and butyrate are produced by bacterial fermentation and reach about 100 mM under physiological conditions. In this decade, SCFA receptor genes and their expression in the intestine have been identified as free fatty acid receptor (FFA)2 and FFA3. The FFAs are located in colonic enteroendocrine L cells producing and releasing an insulinotropic hormone, glucagon-like peptide-1 (GLP-1), and an anorectic hormone, peptide YY. Recent in vivo and in vitro studies suggest that SCFAs stimulate gut hormone secretion. Therefore, the SCFA-FFA signal is likely to be important for gut physiological functions. Key Message: Colonic epithelial cells express chemical receptors that detect the luminal contents, particularly bacterial metabolites, and may be involved in the host's energy metabolism via GLP-1 release, as well as the mucosal defense system.

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Authors: Kaji, I., Karaki, S.-I., & Kuwahara, A.
Affiliations: Hokkaido University (JP)
Shizuoka University (JP)
Corresponding author: Kuwahara, Atsukazu
ORCID: Kaji, Izumi
Karaki, Shin-ichiro
Kuwahara, Atsukazu
Venue: Digestion
Publisher: S. Karger AG
Published: 2014
Volume: 89
Issue: 1
Pages: 31-36
ISSN: 0012-2823 (ISSN-L)
1421-9867
DOI: 10.1159/000356211
OpenAlex: W2046273729
Cited by: 177
References: 31
Citations by year: 2026: 14 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 17 · 2021: 15 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 19 · 2015: 12 · 2014: 3
FWCI: 6.56
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Digestion (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: short-chain fatty acids, FFAR2, GPR40, GPR41, glucagon-like peptide-1, peptide YY, enteroendocrine L cells, gut microbiota, bacterial metabolites, colonic epithelial cells, host-microbiota interactions, gut hormone secretion, energy metabolism, mucosal protection
MeSH terms: Animals, Colon, Dietary Fiber, Fatty Acids, Volatile, Humans, Intestinal Mucosa, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Glucagon-Like Peptide 1, Microbiota

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Short-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release

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