Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.
Open accessAbstract
Suspensions of isolated epithelial cells (colonocytes) from the human colon were used to assess utilisation of respiratory fuels which are normally available to the colonic mucosa in vivo. Cells were prepared from operative specimens of the ascending colon (seven) and descending colon (seven). The fuels that were used were the short chain fatty acid n-butyrate, produced only by anaerobic bacteria in the colonic lumen, together with glucose and glutamine, normally present in the circulation. The percentage oxygen consumption attributable to n-butyrate, when this was the only substrate, was 73% in the ascending colon and 75% in the descending colon. In the presence of 10 mM glucose these proportions changed to 59% and 72%. Aerobic glycolysis was observed in both the ascending and descending colon. Glucose oxidation accounted for 85% of the oxygen consumption in the ascending colon and 30% in the descending colon. In the presence of 10 mM n-butyrate these proportions decreased to 41% in the ascending colon and 16% in the descending colon. Based on the assumption that events in the isolated colonocytes reflect utilization of fuels in vivo, the hypothesis is put forward that fatty acids of anaerobic bacteria are a major source of energy for the colonic mucosa, particularly of the distal colon.
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Butyrate plays a major role in inflammation-related repairs.
“butyrate plays a major role in inflammation-related repairs [236]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [236]
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- Authors
- Roediger, W. E.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Roediger, W E
- ORCID
- Roediger, W E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1980-09
- Volume
- 21
- Issue
- 9
- Pages
- 793-798
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1419533
- OpenAlex
- W2018861313
- Cited by
- 1,310
- References
- 16
- Citations by year
- 2026: 28 · 2025: 29 · 2024: 36 · 2023: 34 · 2022: 49 · 2021: 54 · 2020: 58 · 2019: 46 · 2018: 48 · 2017: 27 · 2016: 32 · 2015: 32 · 2014: 44 · 2013: 28 · 2012: 29
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- anaerobic bacteria, colonic mucosa, colonic epithelial cells, n-butyric acid, short-chain fatty acids, oxygen consumption, glucose oxidation, aerobic glycolysis, glutamine, ascending colon, descending colon
- MeSH terms
- Anaerobiosis, Butyrates, Colon, Glucose, Glutamine, Glycolysis, Humans, Intestinal Mucosa, Ketone Bodies, Oxygen Consumption, Bacterial Physiological Phenomena, In Vitro Techniques
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