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A Randomized Controlled Trial of Mindfulness-Based Stress Reduction to Prevent Flare-Up in Patients with Inactive Ulcerative Colitis
Open accessAbstract
Background/Aims: The primary therapeutic goals in ulcerative colitis (UC) are to maintain excellent quality of life (QOL) by treating flare-ups when they occur, and preventing flare-ups. Since stress can trigger UC flare-ups, we investigated the efficacy of mindfulness-based stress reduction (MBSR) to reduce flare-ups and improve QOL. Methods: Patients with moderately severe UC, in remission, were randomized to MBSR or time/attention control. Primary outcome was disease status. Secondary outcomes were changes in markers of inflammation and disease activity, markers of stress and psychological assessments. Results: 55 subjects were randomized. Absence of flares, time to flare and severity of flare over 1 year were similar between the two groups. However, post hoc analysis showed that MBSR decreased the proportion of participants with at least one flare-up among those with top tertile urinary cortisol and baseline perceived stress (30 vs. 70%; p < 0.001). MBSR patients who flared demonstrated significantly lower stress at the last visit compared to flared patients in the control group (p = 0.04). Furthermore, MBSR prevented a drop in the Inflammatory Bowel Disease Quality of Life Questionnaire during flare (p < 0.01). Conclusion: MBSR did not affect the rate or severity of flare-ups in UC patients in remission. However, MBSR might be effective for those with high stress reactivity (high perceived stress and urinary cortisol) during remission. MBSR appears to improve QOL in UC patients by minimizing the negative impact of flare-ups on QOL. Further studies are needed to identify a subset of patients for whom MBSR could alter disease course.
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“with 12 studies 33 , 37 , 39 , 40 , 42 , 44 , 45 , 50 , 51 , 52 , 54 , 58 reporting significant improvements in stress (Table 4).”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [39]
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“Mindfulness-Based Stress Reduction (MBSR) interventions have been shown to increase the quality of life (Jedel et al., 2014; Goren et al., 2022) and reduce psychological symptoms (Drent et al., 2016; Goren et al., 2022), fatigue (Goren et al., 2022), and the concentration of C-reactive Protein (CRP) and faecal calprotectin in IBD (Berrill et al., 2014; Gonzalez-Moret et al., 2020).”
From Randomized controlled trial of an Acceptance and Commitment Therapy and compassion-based group intervention for persons with inflammatory bowel disease: the LIFEwithIBD intervention (2024) · cites this paper as Jedel et al., 2014
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“Group programmes that included meditation or mindfulness 37 , 39 , 52 or Acceptance‐Commitment Therapy 58 reduced distress and perceived stress.”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [39]
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“Empirical findings suggest that ACT is effective for improving HRQL in clinical samples of adults living with chronic illness such as IBD [13,14] and in parents of children with chronic conditions, chronic pain, and anxiety [11,15,16,17,18].”
From Online Acceptance and Commitment Therapy and Nutrition Workshop for Parents of Children with Inflammatory Bowel Disease: Feasibility, Acceptability, and Initial Effectiveness. (2021) · cites this paper as [13]
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Cites
Mindfulness-based interventions in context: Past, present, and future
Kabat-Zinn, J. (2003) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.bpg016 · Cited by 8,615
Mindfulness-based interventions in context: Past, present, and future.
Kabat-Zinn, J. (2003) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy/bpg016 · Cited by 8,612
Using Self-Report Assessment Methods to Explore Facets of Mindfulness
Baer, R. A., Smith, G. T., Hopkins, J., Krietemeyer, J., & Toney, L. (2006) · Assessment · doi:10.1177/1073191105283504 · Cited by 7,511
(2008) · Medical Entomology and Zoology · Cited by 7,477
Mindfulness-based stress reduction and health benefits
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00573-7 · Cited by 3,958
Depression: Causes and treatment
Beck, A. T. (1973) · Behavior Therapy · doi:10.1016/s0005-7894(73)80054-1 · Cited by 3,163
Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis
Schroeder, K. W., Tremaine, W. J., & Ilstrup, D. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712243172603 · Cited by 3,037
Chiesa, A., & Serretti, A. (2009) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0495 · Cited by 1,681
Mindfulness-based stress reduction and health benefits: A meta-analysis
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2003) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2003.tb04008.x · Cited by 1,394
Speca, M., Carlson, L. E., Goodey, E., & Angen, M. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00004 · Cited by 1,082
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Huang, X., Lv, J., Zhu, D., Peng, H., & Yu, T. (2025) · Biogerontology · doi:10.1007/s10522-025-10287-y · Cited by 7
Watt, M., Peerani, F., Madsen, K. L., Siffledeen, J. S., Kroeker, K. I., Lim, A., Tandon, P., & Hyde, A. M. (2022) · Crohn s & Colitis 360 · doi:10.1093/crocol/otac036 · Cited by 6
Mindfulness Based Therapies for Autoimmune Diseases and Related Symptoms
Penberthy, J. K., Chhabra, D., Avitabile, N., Penberthy, J. M., Le, N., Xu, Y. R., Mainor, S., Schiavone, N., Katzenstein, P., Lewis, J. E., et al. (2018) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.1804039 · Cited by 28
Lang, B. M., Ledergerber, M., Jordi, S. B. U., Krupka, N., Biedermann, L., Schreiner, P., Juillerat, P., Wyss, J., Vavricka, S. R., Zeitz, J., et al. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231179335 · Cited by 6
Jia, J., Wu, Y., Liu, S., Chen, W., Li, R., Bai, Y., & Hu, L. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1593483 · Cited by 5
Beath, A., Mcdonald, K., Osborn, T. C., & Jones, M. P. (2018) · Mindfulness · doi:10.1007/s12671-018-1019-8 · Cited by 5
Treatment Decision-making in Chinese Inflammatory Bowel Disease Patients
Yang, L., Song, X., Chen, Y., Li, Y., Gu, Y., Wang, X., Zhu, L., Zhi, M., Ouyang, C., & Guo, H. Y. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab305 · Cited by 5
Floria, D., Fogarasi, B., Tari, E., Szabó, L., Veres, D. S., Bognár, A. S., Beáta, S., Erőss, B. M., Teutsch, B., & Hegyi, P. J. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251386324 · Cited by 4
Meditation on a Daily Basis Makes Wise without Violence
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Langhorst, J., & Lauche, R. (2014) · Digestion · doi:10.1159/000357368 · Cited by 4
Tse, C. S., Singh, S., & Sandborn, W. J. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab153 · Cited by 3
Psychological Stress and the Kaleidoscope of Autoimmune Diseases
Sharif, Κ., Watad, ., Krosser, A., Coplan, L., Amital, H., Afek, A. B., & Shoenfeld, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814307-0.00033-5 · Cited by 3
Lyall, K., Beswick, L., Evans, S., Cummins, R. A., & Mikocka‐Walus, A. A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.797701 · Cited by 2
The Role of Self-Compassion for Adjustment to Inflammatory Bowel Disease
Yeates, R., & Rowse, G. (2025) · Springer eBooks · doi:10.1007/978-3-031-89095-6_21 · Cited by 1
Doyle, J., Hitchcock, M., & Christie, D. (2019) · BMJ Open Quality · doi:10.1136/bmjoq-2018-000514 · Cited by 1
Diet, Nutrition and Opioid Addiction
Ray, S., & Ongkeko, A. M. (2020) · Journal of Drugs Addiction & Therapeutics · doi:10.47363/jdat/2020(1)101 · Cited by 1
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Alfonsi, J., Conde, E. F. Q., & Troncoso, A. C. (2021) · Psicologia Saúde & Doenças · doi:10.15309/21psd220224
Schacht, S., O’Connor, B., Kirschner, A., Steelman, K., Rosmarin, D. H., & Rubinstein, J. (2022) · Journal of Religion and Health · doi:10.1007/s10943-021-01478-1
Mind-Body Medicine in Children and Adolescents
McClafferty, H. H. (2017) · MDPI eBooks · doi:10.3390/books978-3-03842-529-8
An Exploration of the Effects of Mindfulness on Pain: The Role of Pain Catastrophizing
Haliwa, I. (2022) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.11302
Langhorst, J. (2023) · Springer eBooks · doi:10.1007/978-3-662-64938-1_16
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Vellanki, S., Panganiban, J. A., Erlichman, J., & Mascarenhas, M. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-14744-9_38
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Vogelsänger, P. (2023) · Ärztliche Psychotherapie · doi:10.21706/aep-18-2-85
Garfield, L., Watson‐Singleton, N. N., Mathews, H. L., & Janusek, L. W. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100060 · Cited by 1
Like a Punch in the Gut: A Novel Perspective On Annual Recurrences of Ulcerative Colitis
Johnston, S., Fraser, A., Biddle, C., & Wild, J. (2024) · Crohn s & Colitis 360 · doi:10.1093/crocol/otae050
Cramer, H., & Koch, A. K. (2024) · Springer eBooks · doi:10.1007/978-3-662-68436-8_36
Inflammatory Bowel Disease: Interlinking Psychological Resilience and Anxiety
Chester, M. A., & Keefer, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_25-1
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Nesin, S. M., & Sathyamoorthy, Y. K. (2025) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-7432-0.ch015
(2025) · Elsevier eBooks · doi:10.1016/b978-3-437-21835-4.00116-5
Henney, S. M., & Hackett, J. D. (2025) · Springer eBooks · doi:10.1007/978-3-031-91611-3_9
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Chester, M. A., & Keefer, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_25
Vellanki, S., Holbein, C. E., Boateng, A., Pressman, N., Kirsch, J., Sibinga, E. M. S., Mascarenhas, M., & Albenberg, L. G. (2025) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130251393662
Doyle, J., Shevlin, M. E., Hitchcock, M., Lambert, D., Rao, R., Murray, C. D., McCartney, S. A., Kiparissi, F., & Christie, D. (2025) · Clinical Child Psychology and Psychiatry · doi:10.1177/13591045251406668
ter Avest, M. M., van Velthoven, A. S. M., Speckens, A. E. M., Dijkstra, G., Dresler, M., Horjus, C. S., Römkens, T. E. H., Witteman, E. M., van Dop, W. A., Bredero, Q. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26598239
Qi-wen, F., Jiang, Y.-L., Ge, X.-Y., & Yang, J.-H. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.119197
The Application of Meditation for Treating Physical Illnesses
Song, H. R. (2026) · Springer eBooks · doi:10.1007/978-981-95-7147-5_19
Goyal, M. K., Lee, A., Shah, D., Brehmer, S., Sheehan, J., Berinstein, J. A., Goyal, O., Nero, N. A., Singh, P., & Bishu, S. (2026) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2026.09.022
Metadata
- Authors
- Jedel, S., Hoffman, A., Merriman, P., Swanson, B., Voigt, R., Rajan, K. B., Shaikh, M., Li, H., & Keshavarzian, A.
- Affiliations
- Rush University Medical Center (US)
- University of Chicago (US)
- Rosalind Franklin University of Medicine and Science (US)
- Rush University (US)
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 89
- Issue
- 2
- Pages
- 142-155
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- PMC
- PMC4059005
- OpenAlex
- W1485424371
- Semantic Scholar
- 35e046d57ebe87ffa2080e98775260d22b3e293c
- Cited by
- 143
- References
- 30
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 12 · 2020: 12 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 5 · 2015: 5 · 2014: 2
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Digestion (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Center for Complementary and Integrative Health (R21AT003939)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
- Keywords
- mindfulness-based stress reduction, ulcerative colitis, flare prevention, remission, perceived stress, urinary cortisol, stress reactivity, psychological intervention, inflammatory markers
- MeSH terms
- Adult, Attention, C-Reactive Protein, Colitis, Ulcerative, Double-Blind Method, Feces, Female, Humans, Hydrocortisone, Interleukins, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Stress, Psychological, Time Factors, Disease Progression, Disease-Free Survival, Leukocyte L1 Antigen Complex, Mindfulness
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