Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

Cited by (175)

Items 101–175 of 175

1. Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer
   Cankut Çubuk, Carlos Loucera, María Peña-Chilet, Joaquı́n Dopazo · 2023 · International Journal of Molecular Sciences
2. Soft TCPTP Agonism—Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine
   Carlo Angelo Ghisalberti, Rosa Maria Borzı̀, Silvia Cetrullo, Flavio Flamigni, Gaetano Cairo · 2016 · Frontiers in Pharmacology
3. Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries
   Simone Bohnert, Christoph Reinert, Stefanie Trella, Andrea Cattaneo, Ulrich Preiß, Michael Bohnert, Johann Zwirner, Andreas Büttner, Werner Schmitz, Benjamin Ondruschka · 2024 · Scientific Reports
4. Molecular cloning and mRNA expression analysis of ornithine decarboxylase antizyme 2 in ovarian follicles of the Sichuan white goose (Anser cygnoides)
   Hui He, Bo Kang, Dongmei Jiang, Rong Ma, Lin Bai · 2014 · Gene
5. Understanding the partitioning of polyamines in micelles and delivery to the carrier protein: Thermodynamic approach
   Tinku, Anitadevi K. Prajapati, Sinjan Choudhary · 2021 · Journal of Molecular Liquids
6. Identification and enzymatic properties of arginine decarboxylase from Aspergillus oryzae
   Yui Murakami, Soichiro Ikuta, Wakao Fukuda, Naoki Akasaka, Jun‐ichi Maruyama, Shuichi Shinma, Eiichiro Fukusaki, Shinsuke Fujiwara · 2024 · Applied and Environmental Microbiology
7. A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites
   Lavanya Raajaraam, Karthik Raman · 2022 · Frontiers in Bioengineering and Biotechnology
8. Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF‐κB/STAT‐1 Pathway
   Jun Shu, Yuqiong Jiao, Wenshi Wei, Aijuan Yan · 2025 · Brain and Behavior
9. Determination of polyamines in urine via electrospun nanofibers–based solid‐phase extraction coupled with GC‐MS and application to gastric cancer patients
   Li Xie, Weilin Chen, Qing Shu, Wei Xie, Linxiao Bian, Guozhe Deng, Xuejun Kang, Weihong Ge · 2022 · Journal of Separation Science
10. Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation
    Jiajing Li, Yuxin Sun, Ruyu Yan, Xiaolin Wu, Hualong Zou, Yan Meng · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
11. Dietary probiotic and synbiotic supplementation starting from maternal gestation improves muscular lipid metabolism in offspring piglets by reshaping colonic microbiota and metabolites
    Qian Zhu, Md. Abul Kalam Azad, Ruixuan Li, Chenjian Li, Yang Liu, Yulong Yin, Xiangfeng Kong · 2024 · mSystems
12. A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses
    Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani · 2025 · Medicinal Research Reviews
13. Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
    Dongmei Jiang, Guilin Mo, Yilong Jiang, Bo Kang · 2021 · Open Life Sciences
14. Spermidine, an Autophagy Inducer, as a Therapeutic Antiaging Strategy
    Madhavan Nampoothiri, Kiran Kumar Kolathur, Runali Sankhe, Sairaj Satarker · 2023 · Springer eBooks
15. Can oligomeric proanthocyanidins interfere with UHPLC analysis of spermidine in nutritional supplements?
    Sabrina P. van den Oever, Helmut Karl Mayer · 2022 · Journal of Food Composition and Analysis
16. The interplay of epigenetic remodelling and transposon-mediated genomic instability in ageing and longevity
    Aaron J.J. Lemus, Eyael Tewelde, Rajyk Bhala, Anthony Guan, Alan Xu, Bérénice Anath Benayoun · 2026 · Open Biology
17. Clinical Significance of Topical Spermidine Hyaluronate in Vestibulodynia: An Early Appraisal
    Filippo Murina, Carlo Ghisalberti · 2023 · Open Journal of Obstetrics and Gynecology
18. Structural analysis of carboxyspermidine dehydrogenase from Helicobacter pylori
    Kyung Yeol Ko, Sun Cheol Park, So Yeon Cho, Sung‐il Yoon · 2022 · Biochemical and Biophysical Research Communications
19. Associations of the Single Bovine Embryo Growth Media Metabolome with Successful Pregnancy
    Elina Tsopp, Kalle Kilk, Egon Taalberg, Pille Pärn, Anni Viljaste-Seera, Ants Kavak, Ülle Jaakma · 2024 · Metabolites
20. Practical Synthesis of Spermine, Thermospermine and Norspermine
    Yuka Kariya, Yuta Asanuma, Makoto Inai, Tomohiro Asakawa, Kyoko Ohashi‐Ito, Hiroo Fukuda, Masahiro Egi, Toshiyuki Kan · 2016 · Chemical and Pharmaceutical Bulletin
21. Autophagy in Atherosclerosis
    Mandy O. J. Grootaert, Ammar Kurdi, Dorien G. De Munck, Wim Martinet, Guido R.Y. De Meyer · 2016 · Elsevier eBooks
22. Aging and anti-aging strategies: A review of past and future therapeutics
    Yuqing Wei, Baichen Xiong, Zuoaoyun Song, Sheng Zhong, Na Zheng, Ao Zhang, Yao Chen, Haopeng Sun · 2025 · Bioorganic & Medicinal Chemistry
23. Sequential Nitrile Amidination–Reduction as a Straightforward Procedure to Selective Linear Polyamine Preparation
    Antonio Peñas, José J. Chica-Armenteros, Rubén Cruz-Sánchez, Celeste García-Gallarín, Manuel Melguizo · 2023 · The Journal of Organic Chemistry
24. Spermidine supplementation influence on protective enzymes of Apis mellifera (Hymenoptera: Apidae)
    Tatjana V. Čelić, Srđana Đorđievski, Elvira L. Vukašinović, Ivan I. Pihler, Danijela K. Kojić, Jelena S. Purać · 2024 · Journal of Insect Science
25. Effect of titanium dioxide nanoparticle on proliferation, drug-sensitivity, inflammation, and metabolomic profiling of human oral cells
    René García‐Contreras, Rogelio José Scougall‐Vilchis, Rosalía Contreras‐Bulnes, Masahiro Sugimoto, Hiroshi Nakajima, Hiroshi Sakagami · 2016 · Elsevier eBooks
26. Nutritional Regulation of Aging and Longevity
    Alexey Moskalev · 2021 · Healthy ageing and longevity
27. Calorie Restriction Mimetics: Progress and Potential
    George S. Roth, Donald K. Ingram · 2015 · Healthy ageing and longevity
28. Nutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine
    Natalia Surzenko, Ashley Dominique, Taleen Hanania, Melville C. Osborne, Bassem F. El‐Khodor · 2025 · PLoS ONE
29. Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities
    Yu Lai Yuan, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen · 2024 · Cell Regeneration
30. Using Variable Data-Independent Acquisition for Capillary Electrophoresis-Based Untargeted Metabolomics
    Saki Kiuchi, Yasuhiro Otoguro, Tomoaki Nitta, Mi Hwa Chung, Taiki Nakaya, Yuki Matsuzawa, Katsuya Ohbuchi, Kazunori Sasaki, Hiroyuki Yamamoto, Hiroshi Tsugawa · 2024 · Journal of the American Society for Mass Spectrometry
31. Novel Insight into the Multiple Biological Characteristics of Polyamines in the Gut: From Structure to Function
    Xinyi Yu, Shuzi Xin, Xiaohui Liu, Luming Pan, Weikai Shi, Yize Li, Hongli Wang, Xin Lu, Han Gao, Jingdong Xu · 2025 · Frontiers in Bioscience-Landmark
32. Calorie Restriction Mimetics From Functional Foods
    Wai Yan Sun, Yu Wang · 2017 · Elsevier eBooks
33. Biogenic amines and polyamines in foods of animal origin
    Peter Paulsen, Susanne Bauer, Friedrich Bauer · 2018 · Wageningen Academic Publishers eBooks
34. Bioengineering Microbes for Improved Nutritional Value and Health Benefits.
    Jatan Pandya, Rachana S. Adiga, K Akash, C H Chadhmika, K Niveditha, Debasish Kar · 2023 · Preprints.org
35. Morphological and Molecular Evaluation of a Gel Based on Hyaluronic Acid and Spermidine for Oral Regenerative Purposes
    Dolaji Henin, Elena Canciani, Daniela Carmagnola, Stefano Ferrero, Gaia Pellegrini, Mariachiara Perrotta, Riccardo Sirello, Claudia Paola Bruna Dellavia, Nicoletta Gagliano · 2025 · Cells
36. Modulation of thrombin-induced human platelet activation and oxidative stress by polyamines
    Maria Grazia Signorello · 2026 · Biochemical Pharmacology
37. Autophagy Induction: A Promising Antiaging Strategy
    Abhishek Kumar Singh, Sandeep Singh, Syed Ibrahim Rizvi · 2018 · Springer eBooks
38. The Basics of Biogerontology
    Mark Rinnerthaler, Klaus Richter · 2018 · InTech eBooks
39. Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins
    Guang-Can Shao, Zhen-Lin Chen, Shan Lu, Qingcui Wu, Sheng Yao, Jing Wang, Yan Ma, Jianhua Sui, Hao Chi, Xiang-Bing Qi et al. · 2025 · Molecular & Cellular Proteomics
40. Molecular basis of TRPV3 channel blockade by intracellular polyamines
    Jingying Zhang, Peng Yuan, Colin G. Nichols, Grigory I. Maksaev · 2025 · Communications Biology
41. Fermentation of Microalgae as a Platform for Naturally Encapsulated Oil Powders: Characterization of a High-Oleic Algal Powder Ingredient
    Walter G. Rakitsky, Leon Parker, Kevin Ward, Thomas Pilarski, James Price, Mona Correa, Roberta Miller, Veronica Teixeira Benites, Dino Athanasiadis, Bryce Doherty et al. · 2025 · Microorganisms
42. Causal association of metabolic biomarkers and the risk of esophageal cancer: A 2-sample Mendelian randomization study
    Liu Ziyang, Jinzhou Guo, Wenxuan Du · 2025 · Medicine
43. Crystal structure of apo human spermidine synthase reveals dynamic rearrangement at the active site
    Omowumi O. Fagbohun, Molly A. Canfield, Jonathan A. Clinger · 2026 · Structural Dynamics
44. Anti-Aging Drugs
    Alexander M. Vaiserman · 2016 · Elsevier eBooks
45. Spermidine and its role in inducing autophagy in cardiac muscle to prevent cardiac dysfunction
    Isa Hassan, Leda Mirbahai · 2020 · Reinvention an International Journal of Undergraduate Research
46. Prooxidant-antioxidant balance in the methylotrophic yeast Ogataea polymorpha exoposed to spermidine
    N. V. Hrushanyk, I. A. Sarai, Oleh V. Stasyk, Olena G. Stasyk · 2020 · Studia Biologica
47. Antiaging drugs, candidates, and food supplements: the journey so far
    J.R. Yodhaanjali, Rithwick Surya, K.C. Sumukha, G. Harini, Gouri Deshpande, S A Chandan, Raghu Ram Achar · 2022 · Elsevier eBooks
48. Urine Metabolite of Mice with Orientia tsutsugamushi Infection
    Sangho Choi, Do-Hwan Ahn, Min‐Gyu Yoo, Hye‐Ja Lee, Seong Beom Cho, Hee-Bin Park, Sung Soon Kim, Hyuk Chu · 2023 · American Journal of Tropical Medicine and Hygiene
49. Impact of Cellular Senescence on Cellular Clocks
    Yasukazu Nakahata · 2023 · Healthy ageing and longevity
50. Quantitative Spermidine Detection in Cosmetics using an Organic Transistor‐Based Chemical Sensor
    Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Hikaru Tanaka, Akari Yamagami, Kazutake Hagiya, Tsuyoshi Minami · 2024 · ChemistryOpen
51. Dietary polyamines in Mediterranean diet and their health benefits
    Raymond R. Tjandrawinata · 2016 · Nutrition and Dietary Supplements
52. Self-assembled phenylisoxazole-peptide hybrid assemblies and their interactions with breast and ovarian tumor cells
    Sara K. Hurley, Nicole M. Cutrone, Karl R. Fath, Harrison T. Pajovich, J. De Santiago García, Andrew M. Smith, Ipsita A. Banerjee · 2018 · International Journal of Polymeric Materials
53. Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
    Ana Lambertos, Rafael Peñafiel · 2019 · PLoS ONE
54. Desarrollo de un modelo tridimensional de conjuntiva humana con matrices biocompatibles para el estudio de enfermedades inflamatorias
    Laura García-Posadas · 2015
55. Drosophila-Lactobacillus plantarum as a model of facultative nutritional mutualism
    Théodore Grenier · 2021
56. Aging-Delaying Plant Extracts Cause Age-Related Changes in Cellular and Organellar Lipidomes of the Chronologically Aging Yeast Saccharomyces cerevisiae
    Veronika Svistkova · 2016 · Spectrum Research Repository (Concordia University)
57. Grundlagen der Biogerontologie
    Klaus Richter · 2017 · Springer eBooks
58. Molecular assessment of muscle health and function : The effect of age, nutrition and physical activity on the human muscle transcriptome and metabolom
    Roland Hangelbroek · 2017
59. Unravelling gene regulation in the epidermis during differentiation
    Anisa Banu Abdul Rahim · 2018
60. MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION
    Pavel Kopel, Natalia Cernei, Pavel Horký, Zuzana Lacková, Vedran Milosavljević, Milica Gagić, Ondřej Zítka, Vojtěch Adam · 2020 · NANOCOM ...
61. Ultraviolet B-induced Senescence Model Using Corneal Fibroblasts and the Anti-aging Effect of Angiogenin
    Su Min Sung, Soojin Lee, Kyoo Won Lee, Jae Chan Kim · 2020 · Journal of the Korean Ophthalmological Society
62. Polyamines of biological fluids of the body and the diagnostic value of their determination in clinical and laboratory researches (review of literature)
    М. В. Плосконос · 2021 · Russian Clinical Laboratory Diagnostics
63. CONCENTRATION OF POLYAMINES IN THE RAT LIVER DURING POSTNATAL PERIOD
    Marko Bjelaković, Dusan T. Sokolovic, Milica Bjelaković · 2022 · Facta Universitatis Series Medicine and Biology
64. Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins
    SIAMAK S. TABIBZADEH · 2022 · Aging and Disease
65. Glial Cell Biology and Their Multifaceted Functions in Alzheimer's Disease
    Jawad Laadraoui, Hamid Kabdy, Hajar Azraida, Abdelmohcine Aimrane, Kamal Smimih · 2023 · Advances in bioinformatics and biomedical engineering book series
66. El envejecimiento: ¿Podemos frenarlo? Autofagia/Nutrición. Reprogramación Celular Segunda Parte
    Prof. Jubilado, Universidad Central de Venezuela, Facultad de Farmacia, Cátedra de Biología, María del Rosario Garrido · 2023 · Revista de la Facultad de Farmacia
67. Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging
    Xinyue Liu, Zhijun Deng, Ziyi Wan, Kaixi Pan, Ping Lü · 2025 · The FASEB Journal
68. Small Molecules from Microalgae as an Emerging Sustainable Alternative for Disease Management
    Daniela Treviño-Almaguer, Bryan Alejandro Espinosa-Rodríguez, Isaı́as Balderas-Renterı́a, José Luis González Llerena · 2025 · Springer eBooks
69. Topical Spermidine Hyaluronate (Spd-HA) in Vulvovaginal Atrophy: A Preliminary Study
    Irene Porcari, Michela Carena Maini, Carlo Angelo Ghisalberti, Caterina Tezze, Erica Trimarchi, Alessandra Graziottin, Mariachiara Bosco, Chiara Casprini, Simone Garzon, Stefano Uccella · 2025 · Medicina
70. Comparative Genomic and Metabolomic Characterization of Lactiplantibacillus plantarum LP140 and Bifidobacterium breve BB010 Reveals Distinct Extracellular Metabolic Signatures with Potential Relevance to Gut–Brain Axis-Associated Functions
    Tamara Aleksandrzak‐Piekarczyk, Agnieszka K. Szczepankowska, Mariusz Radkiewicz, Emilia Samborowska, Emilia Majsiak, Božena Cukrowská · 2026 · Research Square
71. Relationship of spermine and spermidine levels with catalase activity in Iraqi women with polycystic ovarian syndrome
    Rahma H. Hamza, J. A. Zainulabdeen · 2026 · AIP conference proceedings
72. Spermidine in Colorectal cancer: friend or foe?
    Sonia Coni, Rosa Bordone, Luca Campea, Shohei Ohno, Gianluca Canettieri, Enzo Agostinelli · 2026 · Amino Acids
73. Near-infrared light-activated collagen-based hydrogel with oriented microchannel structure promoting fibroblast infiltration and inflammatory resolution
    Hui Chen, Yongbin Xu, Ying Zhou, Zhilang Xu, Jimin Guo, Changdao Mu, Defu Li, Liming Ge · 2026 · Collagen and Leather
74. Putrescine-bound structure and multi-temperature crystallography provide new insights into ligand binding and conformational heterogeneity in spermidine synthase
    Omowumi O. Fagbohun, Molly A. Canfield, Jonathan A. Clinger · 2026 · Structural Dynamics
75. Spermidine attenuates cisplatin-induced dorsal lingual injury through modulation of oxidative stress, inflammation, apoptosis, and epithelial proliferation in rats
    Amany Mohamed Shalaby, Khalid Mohammed Mohammed Albakoush, Hamad Alsaykhan, Sulaiman Mohammed Alnasser, Mohammed Alorini, Fatima A. Jaber, Mohamed Ali Alabiad, Amr Mohamed Younes, Shereen Elsayed Tawfeek · 2026 · Tissue and Cell