Cited by 63Pregnancy and preeclampsia studiesNeurological Complications and SyndromesMaternal Mental Health During Pregnancy and Postpartum

Competing risks model in screening for preeclampsia by serum placental growth factor and soluble fms-like tyrosine kinase-1 at 30-33 weeks’ gestation

Lai, Jonathan, Garcia-Tizon Larroca, Santiago, Peeva, Gergana, Poon, Leona C., Wright, David, Nicolaides, Kypros H.·2014·Fetal Diagnosis and Therapy

Abstract

OBJECTIVE: To assess the risk for preeclampsia (PE) by maternal characteristics, serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. METHODS: This was a screening study in singleton pregnancies including 2,140 that subsequently developed PE and 83,615 that were unaffected by PE, gestational hypertension or delivery of small-for-gestational-age neonates (normal group). We developed a survival time model for the time of delivery for PE by combination of maternal characteristics and history with PlGF and sFlt-1 multiple of the median (MoM) values (biochemical test). Data on third-trimester PlGF and sFlt-1 were available in 118 cases of PE and 3,734 of normal group. The detection rate (DR) of PE requiring delivery within 4, 6 and 8 weeks of the visit was estimated. RESULTS: In pregnancies with PE, the log10 MoM values of PlGF and sFlt-1 were linearly related to gestational age at delivery. Screening by the biochemical test detected 100, 76, and 62% of PE with delivery within 4, 6 and 8 weeks of the visit, at a fixed false-positive rate of 5%. INTERPRETATION: Testing by PlGF and sFlt-1 at 30-33 weeks could identify all pregnancies developing PE and requiring delivery within the subsequent 4 weeks.

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Crossref · 10.1159/000359968

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Authors
Lai, J., Garcia-Tizon Larroca, S., Peeva, G., Poon, L. C., Wright, D., & Nicolaides, K. H.
Affiliations
  • Harris Birthright Research Centre for Fetal Medicine (GB)
  • University of Exeter (GB)
Venue
Fetal Diagnosis and Therapy
Publisher
S. Karger AG
Published
2014
Volume
35
Issue
4
Pages
240-248
ISSN
  • 1015-3837 (ISSN-L)
  • 1421-9964
OpenAlex
W1972743675
Cited by
63
References
36
Citations by year
2026: 3 · 2025: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 12 · 2018: 4 · 2017: 3 · 2016: 11 · 2015: 10 · 2014: 5
FWCI
10.26
Type
journal article
Language
en
Open access
closed
Locations
  • Fetal Diagnosis and Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research (ACF-2013-21-016)
  • Fetal Medicine Foundation
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
preeclampsia, preeclampsia screening, placental growth factor, soluble fms-like tyrosine kinase-1, sFlt-1/PlGF ratio, third trimester, gestational age at delivery, detection rate, false positive rate, singleton pregnancy, gestational hypertension
MeSH terms
Placenta Growth Factor, Adult, Female, Gestational Age, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Pregnancy Proteins, Pregnancy Trimester, Third, Regression Analysis, Biomarkers, Risk Assessment, Vascular Endothelial Growth Factor Receptor-1

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