The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids
Open accessAbstract
Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response to stress. Since their discovery in the 1940s, glucocorticoids have been widely prescribed to treat inflammatory disorders and hematological cancers. In the traditional view, glucocorticoids are regarded as anti-inflammatory molecules; however, emerging evidence suggests that glucocorticoid actions are more complex than previously anticipated. The anti-inflammatory activity of glucocorticoids is attributed to the repression of pro-inflammatory genes through signal transduction by their steroid receptor, the glucocorticoid receptor (GR). The mechanisms modulating the pro-inflammatory effects of glucocorticoids are not well understood. In this review, we discuss recent findings that provide insights into the mechanism by which GR signaling can play a dual role in the regulation of the immune response. We hypothesize that these apparently opposite processes are working together to prepare the immune system to respond to a stressor (pro-inflammatory effects) and subsequently restore homeostasis (anti-inflammatory effects). Finally, we propose that determining the mechanisms which underlie the tissue-specific effects of glucocorticoids will provide an excellent tool to develop more efficient and selective glucocorticoid therapies.
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Cites
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Self-citationPrimary structure and expression of a functional human glucocorticoid receptor cDNA
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Metadata
- Authors
- Cruz-Topete, D., & Cidlowski, J. A.
- Venue
- Neuroimmunomodulation
- Publisher
- S. Karger AG
- Published
- 2014-09-12
- Volume
- 22
- Issue
- 1-2
- Pages
- 20-32
- ISSN
- 1021-7401 (ISSN-L)
- 1423-0216
- OpenAlex
- W2025175138
- Cited by
- 454
- References
- 84
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
