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Cited by 566

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

Open access
Tomino, Yasuhiko·2014·Kidney and Blood Pressure Research
DOI 10.1159/000368458
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Abstract

Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end stage kidney disease (ESKD) are chronic glomerulonephritis (particularly IgA nephropathy), type 2 diabetic nephropathy, and hypertensive nephrosclerosis. Hypertension is a major factor driving the progression of CKD to ESKD. Since many features of the pathogenesis of IgA nephropathy are still obscure, specific treatment is not yet available. However, efforts by investigators around the world have gradually clarified different aspects of the pathogenesis and treatment of IgA nephropathy. Today, around half of all diabetic patients in Japan receive medical treatment. Type 2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of Japanese diabetic patients. The pathogenesis of diabetic nephropathy involves both genetic and environmental factors. However, the candidate genes related to the initiation and progression of the disorder are still obscure in patients with diabetic nephropathy. Regarding environmental factors, the toxicity of persistent hyperglycemia, reactive oxygen species, systemic and/or glomerular hypertension, dyslipidemia and complement are considered to play an important role. The first part of this review covers the pathogenesis of IgA nephropathy and type 2 diabetic nephropathy, and combines the clinicopathological findings in patients with our research on the ddY and KKA-y mouse models (spontaneous animal models for IgA nephropathy and diabetic nephropathy, respectively). In Japan, the major renal replacement therapies (RRT) are peritoneal dialysis (PD) and hemodialysis (HD). The second part of this review focuses on PD and HD. Based on our research findings from patients and as well as from animal models, we discuss strategies for the management of patients on PD and HD. i 2015 S. Karger AG, Basel

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Metadata

Authors
Tomino, Y.
Venue
Kidney and Blood Pressure Research
Publisher
S. Karger AG
Published
2014
Volume
39
Issue
5
Pages
450-489
ISSN
  • 1420-4096 (ISSN-L)
  • 1423-0143
DOI
10.1159/000368458
OpenAlex
W2029774820
Cited by
566
References
90
FWCI
44.43
Type
journal article
Language
en
Open access
gold
Licence

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Tomino, Y. (2014). Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data. Kidney and Blood Pressure Research. https://doi.org/10.1159/000368458

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