Ginsenoside Rb2 Attenuates UV-B Radiation-Induced Reactive Oxygen Species and Matrix Metalloproteinase-2 through Upregulation of Antioxidant Components in Human Dermal Fibroblasts
Abstract
Aims: The antiphotoaging activities of ginsenoside Rb2 on the skin, one of the predominant protopanaxadiol-type ginsenosides, were evaluated in cultured human dermal fibroblasts. Methods: The antiphotoaging activity was examined by analyzing the levels of reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total glutathione (GSH) and superoxide dismutase (SOD) activity as well as cell viability for fibroblasts under UV-B irradiation. Results: When cultured fibroblasts were exposed to Rb2 prior to UV-B irradiation, Rb2 displayed suppressive activities on UV-B-induced ROS elevation and MMP-2 on both activity and protein levels, while it exhibited an enhancing activity on total GSH level and SOD activity diminished by UV-B irradiation. However, Rb2 could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Conclusion: Ginsenoside Rb2 plays a photoprotective role against UV-B-induced oxidative stress in human dermal fibroblasts, which implies its skin antiphotoaging potential.
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P. ginseng exerts protective effects against skin aging by reducing inflammation and stimulating collagen synthesis, as demonstrated in in vitro and in vivo models.
“Numerous pharmacological studies have confirmed that P. ginseng exerts protective effects against skin aging by mechanisms such as reducing inflammation and stimulating collagen synthesis, as demonstrated through both in vitro and in vivo experimental models [10,11,12,13,14].”
From Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage (2024) · cites this paper as [12]
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Birch-Machin, M. A., & Swalwell, H. (2010) · Mutagenesis · doi:10.1093/mutage/gep061 · Cited by 159 · see citing works
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Kang, M., Park, S., Son, S.-R., Noh, Y., Jang, D. S., & Lee, S. (2024) · Molecules · doi:10.3390/molecules29225479 · Cited by 23 · see citing works
- Authors
- Oh, S.-J., Kim, K., & Lim, C.-J.
- Affiliations
- Kangwon National University (KR)
- Venue
- Pharmacology
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 96
- Issue
- 1-2
- Pages
- 32-40
- ISSN
- 0031-7012 (ISSN-L)
- 1423-0313
- OpenAlex
- W1577169337
- Cited by
- 18
- References
- 1
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kangwon National University
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- ginsenoside Rb2, UV-B radiation, photoprotection, reactive oxygen species, MMP-2, oxidative stress, dermal fibroblasts, glutathione, superoxide dismutase, antioxidant enzymes, cell viability
- MeSH terms
- Antioxidants, Cell Survival, Cells, Cultured, Enzyme Induction, Fibroblasts, Glutathione, Humans, Superoxide Dismutase, Ultraviolet Rays, Up-Regulation, Reactive Oxygen Species, Dermis, Matrix Metalloproteinase 2, Ginsenosides
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