Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy
Open accessAbstract
Lipoprotein glomerulopathy (LPG) is characterized by histopathological features showing intra-glomerular lipoprotein thrombi and type III hyperlipoproteinemia (HLP), with heterozygote mutation of apolipoprotein (apo) E gene. On the other hand, as another renal lipidosis with type III HLP, apoE2 homozygote-related glomerulopathy (apoE2-GN) showing foamy macrophages has been reported. The case of a 25-year-old man who had LPG by clinical behavior and gene analysis, but demonstrated atypical histopathological features with a substantial amount of foamy macrophage infiltration in the glomeruli, is presented. The combination of alleles for apoE Tokyo/Maebashi and classical apoE2 (Arg158Cys) was inferred to be the leading cause of the unique renal pathology with lipoprotein thrombi and foamy macrophages. In addition, foamy macrophages infiltrated some part of the apoE-positive region within the glomerulus, but did not exist in lipoprotein thrombi despite apoE positivity, suggesting that properties of apoE are crucial in the development of LPG rather than macrophage function. This case provides important information related to the pathogenesis of LPG and apoE2-GN.
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The APOE Tokyo/Maebashi mutation is found at the LDL receptor binding site of apoE.
“The APOE Tokyo/Maebashi mutation is found at the LDL receptor binding site of apoE,13 which is where most mutations associated with LPG occur.35”
From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [13]
The Case Report section (Phenotype, Genotype, and DNA Sequence Analysis of apoE; page unavailable) identifies Tokyo/Maebashi as a deletion at codons 141–143. Neither that section nor the Discussion identifies those codons as the LDL receptor-binding site, so the specific site claim is not established by our copy. (LLM, conf=0.78)
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Cites
Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia
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Apolipoprotein E–related glomerular disorders
Saito, T., Matsunaga, A., Fukunaga, M., Nagahama, K., Hara, S., & Muso, E. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.031 · Cited by 77 · see citing works
Self-citationLipoprotein Glomerulopathy, First Case Report from Canada
Ting, J. A., McRae, S. A., Schwartz, D., Barbour, S. J., & Riazy, M. (2022) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s364890 · Cited by 7 · see citing works
Wang, R., Zhao, C., Chen, W., Liu, Z., & Xie, F. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-022-03302-0 · Cited by 5 · see citing works
- Authors
- Takasaki, S., Maeda, K., Joh, K., Yamakage, S., Fukase, S., Takahashi, T., Suzuki, M., Matsunaga, A., & Saito, T.
- Affiliations
- Yamagata Saisei Hospital (JP)
- Yamagata Prefectural University of Health Sciences (JP)
- Tohoku University (JP)
- Yamagata Prefectural Central Hospital (JP)
- Fukuoka University (JP)
- Corresponding author
- Takasaki, Satoshi
- Venue
- Case Reports in Nephrology and Dialysis
- Publisher
- S. Karger AG
- Published
- 2015-12-15
- Volume
- 5
- Issue
- 3
- Pages
- 204-212
- ISSN
- 2296-9705 (ISSN-L)
- PMC
- PMC4777904
- OpenAlex
- W2231013303
- Cited by
- 7
- References
- 3
- Citations by year
- 2024: 1 · 2022: 3 · 2019: 1 · 2018: 1 · 2016: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Case Reports in Nephrology and Dialysis (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- lipoprotein glomerulopathy, apolipoprotein E, foam cells, macrophage infiltration, type III hyperlipoproteinemia, glomerular pathology, APOE genotype, pathogenesis
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