Lipoprotein Glomerulopathy
Abstract
Lipoprotein glomerulopathy is a disease characterized by intraglomerular lipoprotein thrombi and abnormal lipid metabolism similar to type III hyperlipoproteinemia. Recently, glomerular lesions compatible with lipoprotein glomerulopathy were found in a 38-year-old man. In this case, plasma apolipoprotein (apo) E level was elevated, and the apo E isoform was heterozygous E2/3, similar to most of the reported cases of lipoprotein glomerulopathy. However, the plasma levels of triglyceride and total cholesterol were within their respective normal ranges. Review in 11 cases revealed that lipoprotein glomerulopathy was not always associated with hyperlipidemia, and that apo E abnormality was always recognized. These findings suggest that lipoprotein thrombi associated with lipoprotein glomerulopathy are not induced via systemic hyperlipidemia but may be formed by intraglomerular accumulation of lipoprotein composed of abnormal apo E.
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In previous studies on LPG, osmiophilic granular substances were reported in the subendothelial and mesangial areas.
“In previous studies on LPG, osmiophilic granular substances were reported in the subendothelial and mesangial areas [10, 11, 12], and one of them showed ApoE deposition and microbubbles like in the current case [10].”
From Membranous Nephropathy-Like Apolipoprotein E Deposition Disease with Apolipoprotein E Toyonaka (Ser197Cys) and a Homozygous Apolipoprotein E2/2 (2018) · cites this paper as [12]
Normolipidemic or mildly hyperlipidemic cases of LPG have been reported, regardless of whether the apoE mutations are located within or distant from the LDL receptor-binding area.
“However, normolipidemic or mildly hyperlipidemic cases of LPG have also been reported, regardless of whether the apoE mutations are located within or distant from the LDL receptor-binding area17–19).”
From The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T＞C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy (2018) · cites this paper as [19]
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Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy
Syrjänen, J., Mustonen, J. T., & Pasternack, A. I. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.1.34 · Cited by 256 · see citing works
Apolipoprotein E and atherosclerosis: insight from animal and human studies
Davignon, J., Cohn, J. S., Mabile, L., & Bernier, L. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00097-2 · Cited by 208 · see citing works
Keane, W. F. (1994) · Kidney International · doi:10.1038/ki.1994.349 · Cited by 205 · see citing works
Araki, S., Moczulski, D. K., Ficociello, L., Scott, L. J., Warram, J. H., & Królewski, A. S. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2190 · Cited by 108 · see citing works
Impact of Lipoprotein Glomerulopathy on the Relationship Between Lipids and Renal Diseases
Saito, T., Matsunaga, A., & Oikawa, S. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.10.017 · Cited by 96 · see citing works
Self-citationApolipoprotein E and renal disease
Liberopoulos, E. N., Siamopoulos, K. C., & Elisaf, M. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.10.013 · Cited by 93 · see citing works
A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy
Matsunaga, A., Sasaki, J., Komatsu, T., Kanatsu, K., Tsuji, E., Moriyama, K., Koga, T., Arakawa, K., Oikawa, S., Saito, T., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00572.x · Cited by 91 · see citing works
Self-citationChew, S. T. H., Newman, M. F., White, W. D., Conlon, P. J., Saunders, A. M., Strittmatter, W. J., Landolfo, K. P., Grocott, H. P., & Stafford‐Smith, M. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00008 · Cited by 81 · see citing works
Apolipoprotein E–related glomerular disorders
Saito, T., Matsunaga, A., Fukunaga, M., Nagahama, K., Hara, S., & Muso, E. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.031 · Cited by 77 · see citing works
Self-citationHu, Z., Huang, S., Wu, Y., Liu, Y., Liu, X., Su, D., Tao, Y., Fu, P., Zhang, X., Peng, Z., et al. (2014) · Kidney International · doi:10.1038/ki.2013.335 · Cited by 60 · see citing works
Konishi, K., Saruta, T., Kuramochi, S., Oikawa, S., Saito, T., Han, H., Matsunaga, A., & Sasaki, J. (1999) · Nephron · doi:10.1159/000045513 · Cited by 54 · see citing works
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Sam, R., Wu, H., Yue, L., Mazzone, T., Schwartz, M. M., Arruda, J. A. L., Dunea, G., & Singh, A. K. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.12.031 · Cited by 53 · see citing works
Lipoprotein glomerulopathy: renal lipidosis induced by novel apolipoprotein E variants
Saito, T., Oikawa, S., Sato, H., & Sasaki, J. (1999) · Nephron · doi:10.1159/000045511 · Cited by 46 · see citing works
Self-citationHOFFMANN, M. M., SCHARNAGL, H., PANAGIOTOU, E., BANGHARD, W. T., WIELAND, H., & MA[Combining Diaeresis]RZ, W. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v123524 · Cited by 42 · see citing works
A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy
Ogawa, T., Maruyama, K., Hattori, H., Arai, H., Kondoh, I., Egashira, T., Watanabe, T., Kobayashi, Y., & Morikawa, A. (2000) · Pediatric Nephrology · doi:10.1007/s004670050032 · Cited by 37 · see citing works
Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features
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Davignon, J., & Genest, J. J. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70024-4 · Cited by 37 · see citing works
Luo, B., Huang, F., Liu, Q., Li, X., Chen, W., Zhou, S.-F., & Yu, X. (2008) · American Journal of Nephrology · doi:10.1159/000111828 · Cited by 36 · see citing works
Novel glomerular lipoprotein deposits associated with apolipoprotein E2 homozygosity
Sakatsume, M., Kadomura, M., Sakata, I., Imai, N., Kondo, D., Osawa, Y., Shimada, H., Ueno, M., Miida, T., Nishi, S., et al. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590051911.x · Cited by 46 · see citing works
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy
Hagiwara, M., Yamagata, K., Matsunaga, T., Arakawa, Y., Usui, J., Shimizu, Y., Aita, K., Nagata, M., Koyama, A., Zhang, B., et al. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm735 · Cited by 27 · see citing works
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Lipoprotein glomerulopathy: a pediatric case report
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Self-citationIto, K., Nakashima, H., Watanabe, M., Ishimura, A., Miyahara, Y., Abe, Y., Yasuno, T., Ifuku, M., Sasatomi, Y., & Saito, T. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs329 · Cited by 21 · see citing works
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Self-citationIshimura, A., Watanabe, M., Nakashima, H., Ito, K., Miyake, K., Mochizuki, S., Ishigaki, Y., & Saito, T. (2009) · Clinical and Experimental Nephrology · doi:10.1007/s10157-009-0195-1 · Cited by 17 · see citing works
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Xue, C., Nie, W., Tang, D., Yi, L., & Mei, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083367 · Cited by 16 · see citing works
Association of Apolipoprotein E Polymorphism with Lipoprotein Glomerulopathy
Yang, A. H., Ng, Y. Y., Tarng, D., Chen, J. Y., Shiao, M. S., & Kao, J. (1998) · The Nephron journals/Nephron journals · doi:10.1159/000044933 · Cited by 16 · see citing works
Fukunaga, M., Nagahama, K., Aoki, M., Shimizu, A., Hara, S., Matsunaga, A., Muso, E., & Saito, T. (2018) · Case Reports in Nephrology and Dialysis · doi:10.1159/000487919 · Cited by 14 · see citing works
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Lipoprotein glomerulopathy with a new apolipoprotein E phenotype
Komatsu, T., Kanatsu, K., Ochi, H., Kita, T., & Doi, T. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90581-2 · Cited by 12 · see citing works
Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town
Pasquariello, A., Pasquariello, G., Innocenti, M., Minnei, F., Funel, N., Lorusso, P., & Barsotti, G. (2011) · Journal of Nephrology · doi:10.5301/jn.2011.7772 · Cited by 14 · see citing works
Lipoprotein Glomerulopathy and Its Pathogenesis
Saito, T., Oikawa, S., Sato, H., & Chiba, J. (1997) · Contributions to Nephrology · doi:10.1159/000059821 · Cited by 12 · see citing works
Self-citationA newborn infant with lipoprotein glomerulopathy associated with congenital nephrotic syndrome
Shimizu, M., Ohno, T., Kimoto, H., Hosono, S., & Nozawa, M. (2001) · Pediatrics International · doi:10.1046/j.1442-200x.2001.01344.x · Cited by 8 · see citing works
Qin, Y., Sun, X.-J., Hu, Y.-F., Jing, M., Yu, X.-J., Zhao, M.-H., & Tan, Y. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2332491 · Cited by 7 · see citing works
Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy
Takasaki, S., Maeda, K., Joh, K., Yamakage, S., Fukase, S., Takahashi, T., Suzuki, M., Matsunaga, A., & Saito, T. (2015) · Case Reports in Nephrology and Dialysis · doi:10.1159/000441715 · Cited by 7 · see citing works
Self-citationA young Chinese man with nephrotic syndrome due to lipoprotein glomerulopathy
Lui, D. T. W., Lee, A. C. H., Yap, D. Y. H., Chan, G. S. W., & Tan, K. C. B. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.12.004 · Cited by 6 · see citing works
Cheung, C. Y., Chan, A. O. K., Chan, G. P. T., Iu, H. Y. P., Shek, C. C., & Chau, K. (2014) · Clinical Kidney Journal · doi:10.1093/ckj/sfu058 · Cited by 6 · see citing works
Case Report: A Pediatric Case of Lipoprotein Glomerulopathy in China and Literature Review
Song, Y., Yang, C., Liu, L., & Wang, H. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.684814 · Cited by 5 · see citing works
Lechleitner, M. (2000) · Journal of clinical and basic cardiology · Cited by 3 · see citing works
Shaker, N., Musa, R. B., Shaker, N., Nasir, H., Kamran, T. E., Poombal, F., Abid, A., Shakra, R. I. A., & Mansoor, I. (2024) · International Journal of Surgical Pathology · doi:10.1177/10668969241228298 · Cited by 3 · see citing works
Normolipidemic lipoprotein glomerulopathy with IgA nephropathy — ApoE Kyoto mutation: a case report
Yi, X., Bai, L., Chen, K., He, Y., & Chen, J. (2025) · Diagnostic Pathology · doi:10.1186/s13000-025-01636-z · Cited by 2 · see citing works
Pourmand, D., Veisi-Raygani, A., Bahrehmand, F., & Asadi, S. (2023) · PubMed Central · doi:10.30476/ijms.2022.94850.2616 · Cited by 2 · see citing works
Renal Diseases and Abnormal Lipid Metabolism
Okubo, M., Kobayashi, N., Nakamura, M., & Naito, M. (2006) · Journal of Rural Medicine · doi:10.2185/jrm.1.2_13 · Cited by 1 · see citing works
Increased frequency of the apolipoprotein E2 allele in maintenance haemodialysis patients in Taiwan
Hsieh, M., Lin, S., Lo, C., Hsin, S., Chen, H., & Shin, S. (2002) · Nephrology · doi:10.1046/j.1440-1797.2002.00132.x · Cited by 1 · see citing works
Dyslipidémie et complications micro-angiopathiques du diabète sucré
Durlach, V. (2008) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(08)70005-1
FIELD deux ans après : quelle place pour les fibrates dans le diabète de type 2 ?
Vergès, B. L. (2008) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(08)70007-5
A new variant of apolipoprotein E in a girl with lipoprotein glomerulopathy.
Ogawa, T., Arai, H., Watanabe, T., Kobayashi, Y., Morikawa, A., Maruyama, K., Hattori, H., & Egashira, T. (1998) · Japanese journal of pediatric nephrology · doi:10.3165/jjpn.11.171
斉藤, 喬., 克也, 小., & 眞一, 及. (1994) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.83.1793
Disease state of lipoprotein glomerulopathy.
斉藤, 喬. (2006) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.95.1838
Keane, W. F. (1994)
KIDNEY BIOPSY TEACHING CASE A Rare Cause of Posttransplantation Nephrotic Syndrome
Foster, K. W., Matsunaga, A., Matalon, R., Saito, T., Gallo, G., & Stokes, M. B. (2005)
Self-citationLechleitner, M. (2000) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Apolipoprotein E Dyslipidemia and Nephrotic Syndrome: A Rare Connection
Tito, S., Atri, A., Patil, S. P., Dean, S., & Carpenter, S. (2023) · Annals of Internal Medicine Clinical Cases · doi:10.7326/aimcc.2023.0059
- Authors
- Saito, T., Sato, H., Oikawa, S., Kudo, K., Kurihara, I., Nakayama, K., Abe, K., Yoshinaga, K., & Sakaguchi, H.
- Affiliations
- Tohoku University (JP)
- Yamagata City Hospital Saiseikan (JP)
- Keio University (JP)
- Venue
- American Journal of Nephrology
- Publisher
- S. Karger AG
- Published
- 1993
- Volume
- 13
- Issue
- 1
- Pages
- 64-68
- ISSN
- 0250-8095 (ISSN-L)
- 1421-9670
- OpenAlex
- W218540132
- Cited by
- 57
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2019: 1 · 2018: 4 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- lipoprotein glomerulopathy, apolipoprotein E, type III hyperlipoproteinemia, abnormal lipid metabolism, hyperlipidemia, glomerular lesions
- MeSH terms
- Adult, Apolipoproteins E, Biopsy, Follow-Up Studies, Glomerulonephritis, Humans, Hyperlipidemias, Kidney, Male, Apolipoprotein E3, Apolipoprotein E2
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