Cerebral β-Amyloid Angiopathy Is Associated with Earlier Dementia Onset in Alzheimer's Disease
Open accessAbstract
BACKGROUND: Cerebral β-amyloid angiopathy (CAA) occurs when β-amyloid (Aβ) is deposited in the vascular media and adventitia. It is a common pathology in the brains of older individuals and has been linked to cognitive decline, but relatively little is known about the influence that CAA has on the clinical manifestation of Alzheimer's disease (AD). The aim of this retrospective analysis was to quantify the effect that CAA had on the manifestation of initial AD-related cognitive change and subsequent progression of dementia. METHODS: We analyzed neuropathological data from the National Alzheimer's Coordinating Center's data set, performing parametric analyses to assess differences in age of progression to moderate-stage dementia. RESULTS: We found that individuals with both CAA burden and Aβ neuritic plaque burden at death had the greatest risk of earlier conversion to very mild and moderate-stage dementia, but not necessarily faster progression. CONCLUSIONS: Our results suggest that CAA contributes to changes in early AD pathogenesis. This supports the idea that vascular change and neuritic plaque deposition are not just parallel processes but reflect additive pathological cascades that influence the course of clinical AD manifestation. Further inquiry into the role of CAA and its contribution to early cognitive change in AD is suggested.
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The preponderance of cerebral amyloid angiopathy in Alzheimer's disease and its association with an earlier age of onset support its role in the disease process, independently contributing to clinical presentations of Alzheimer's disease.
“The preponderance of CAA in AD and its association with an earlier age of onset support its role on the disease process, independently contributing to clinical presentations of AD [46, 49, 50].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [49]
The Discussion (page unavailable) says CAA and neuritic plaques may be additive pathological processes that influence the timing of clinical change, and the Results associate combined CAA and plaque burden with earlier dementia. But the Introduction calls CAA common in older adults without establishing its preponderance in AD, and the observational findings do not establish an independent causal contribution. (LLM, conf=0.82)
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Scholtzova, H., Do, E., Dhakal, S., Sun, Y., Liu, S., Mehta, P. D., & Wisniewski, T. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1967-16.2016 · Cited by 82 · see citing works
- Authors
- Vidoni, E. D., Yeh, H.-W., Morris, J. K., Newell, K. L., Alqahtani, A., Burns, N. C., Burns, J. M., & Billinger, S. A.
- Affiliations
- University of Kansas Medical Center (US)
- ORCID
- Venue
- Neurodegenerative Diseases
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 16
- Issue
- 3-4
- Pages
- 218-224
- ISSN
- 1660-2854 (ISSN-L)
- 1660-2862
- PMC
- PMC4915344
- OpenAlex
- W2289711228
- Cited by
- 37
- References
- 0
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurodegenerative Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (K99AG050490, U01AG016976, P30AG035982)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K01HD067318)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- Alzheimer's disease, dementia onset, dementia progression, vascular pathology, cognitive decline, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Severity of Illness Index, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Age of Onset, Disease Progression, Plaque, Amyloid
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