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Hyperinsulinemic Hypoglycemia after Bariatric Surgery: Diagnosis and Management Experience from a Spanish Multicenter Registry
Open accessAbstract
BACKGROUND: Severe postprandial hypoglycemia after bariatric surgery is a rare but invalidating complication. Our aim was to describe the different tests performed for its diagnosis and their outcomes as well as the response to the prescribed pharmacological and surgical treatments. METHODS: Multicenter, retrospective systematic review of cases with recurrent severe postprandial hypoglycemia. RESULTS: Over 11 years of follow-up, 22 patients were identified. The test most used to provoke hypoglycemia was the oral glucose load test followed by the mixed meal test which was the least standardized test. With pharmacological treatment, 3 patients were symptom-free (with octreotide) and in 12 patients hypoglycemic episodes were attenuated. Seven patients had persistent hypoglycemic episodes and underwent surgery. Partial pancreatectomy was performed in 3 patients who had positive selective arterial calcium stimulation, and nesidioblastosis was confirmed in 2 patients. Reconversion to normal anatomy was performed in 3 patients, and 1 patient underwent a resection of the 'candy cane' roux limb, with resolution of hypoglycemia in all cases. CONCLUSIONS: There is high heterogeneity in the evaluation and treatment options for postoperative hypoglycemia. In patients that do not respond to pharmacological treatment, reconstruction of gastrojejunal continuity may be the safest and most successful procedure.
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“Pancreatic resection, the most commonly reported procedure, was performed in approximately 67% of patients (66,103,105,107,114,116-123).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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“Administration of nifedipine in combination with verapamil to 10 patients who developed hyperinsulinemic hypoglycemia after bariatric surgery resulted in a partial response in five patients (50%) (66).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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In the citing paper
“Both short-acting and long-acting formulations of somatostatin analogues have demonstrated efficacy by slowing gastric emptying, improving hypoglycemia and reducing early and late dumping symptoms (Table 4) (15,66,(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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“A recent multicenter, retrospective, systematic case series reported that treatment of six patients who developed hyperinsulinemic hypoglycemia after bariatric surgery with diazoxide (168.7 ± 94 mg/day orally) resulted in a partial response (defined as a 50% reduction in the number and severity of hypoglycemic events) in three patients (50%) (66).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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“Various surgical re-interventions have been used, including gastric tube placement, gastric bypass reversal with or without concomitant sleeve resection and gastric pouch restriction (Table 5) (66,103,105-123).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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“As shown in Table 5, approximately 24% of patients who underwent surgical re-intervention because of refractory severe post-Roux-en-Y gastric bypass hypoglycemia received a gastric bypass reversal (66,103,106-113) and approximately 9% had gastric pouch restriction (66,114,115).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [66]
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Citations
Cites
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.
Service, G. J., Thompson, G. B., Service, F. J., Andrews, J. C., Collazo-Clavell, M. L., & Lloyd, R. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043690 · Cited by 779
Goldfine, A. B., Mun, E. C., Devine, E., Bernier, R., Baz-Hecht, M., Jones, D. B., Schneider, B. E., Holst, J. J., & Patti, M. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0918 · Cited by 377
Patti, M. E., McMahon, G., Mun, E. C., Bitton, A., Holst, J. J., Goldsmith, J., Hanto, D. W., Callery, M., Arky, R., Nose, V., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1933-x · Cited by 365
Salehi, M., Prigeon, R. L., & D’Alessio, D. A. (2011) · Diabetes · doi:10.2337/db11-0203 · Cited by 323
Marsk, R., Jonas, E., Rasmussen, F., & Näslund, E. (2010) · Diabetologia · doi:10.1007/s00125-010-1798-5 · Cited by 273
Meier, J. J., Butler, A. E., Galasso, R., & Butler, P. C. (2006) · Diabetes Care · doi:10.2337/dc06-0392 · Cited by 249
McLaughlin, T., Peck, M., Holst, J., & Deacon, C. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1628 · Cited by 183
Kefurt, R., Langer, F. B., Schindler, K., Shakeri‐Leidenmühler, S., Ludvik, B. H., & Prager, G. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.11.003 · Cited by 151
The Diagnosis of Postprandial Hypoglycemia
Lev-Ran, A., & Anderson, R. W. (1981) · Diabetes · doi:10.2337/diab.30.12.996 · Cited by 148
Moreira, R. O., Moreira, R., Machado, N., Gonçalves, T. B., & Coutinho, W. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9569-9 · Cited by 136
Severe Recurrent Hypoglycemia after Gastric Bypass Surgery
Z’graggen, K., Guweidhi, A., Steffen, R., Potoczna, N., Biral, R., Walther, F., Komminoth, P., & Horber, F. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9480-4 · Cited by 125
Won, J. G. S., Tseng, H., Yang, A., Tang, K., Jap, T., Lee, C. H., Lin, H., Burcus, N. I., Pittenger, G. L., & Vinik, A. I. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02629.x · Cited by 108
Vidal, J., Nicolau, J., Romero, F., Casamitjana, R., Momblan, D., Conget, I., Morínigo, R., & Lacy, A. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1620 · Cited by 94
Continuous Glucose Monitoring for Evaluation of Glycemic Excursions after Gastric Bypass
Halperin, F., Patti, M., Skow, M., Bajwa, M. A., & Goldfine, A. B. (2011) · Journal of Obesity · doi:10.1155/2011/869536 · Cited by 91
Rabiee, A., Magruder, J., Salas-Carrillo, R., Carlson, O., Egan, J. M., Askin, F., Elahi, D., & Andersen, D. K. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.09.047 · Cited by 85
Successful Medical Management of Status Post-Roux-en-Y-Gastric-Bypass Hyperinsulinemic Hypoglycemia
Spanakis, E., & Gragnoli, C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9888-5 · Cited by 83
Hypoglycemia after Roux-en-Y Gastric Bypass: The BOLD Experience
Sarwar, H., Chapman, W. H. H., Pender, J. R., Ivanescu, A. E., Drake, A. J., Pories, W. J., & Dar, M. S. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1260-8 · Cited by 83
Myint, K. S., Greenfield, J. R., Farooqi, I. S., Henning, E., Holst, J. J., & Finer, N. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1065 · Cited by 77
Maternal and Perinatal Outcomes After Bariatric Surgery: a Spanish Multicenter Study
González, I., Rubio, M. Á., Cordido, F., Lesmes, I. B., Morales, M. J., Vilarrasa, N., Monereo, S., Lecube, A., Caixàs, A., Vinagre, I., et al. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1387-7 · Cited by 75
Self-citationHypoglycemia After Gastric Bypass: The Dark Side of GLP-1
Patti, M., & Goldfine, A. B. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.038 · Cited by 69
Cui, Y., Elahi, D., & Andersen, D. K. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1585-8 · Cited by 66
Hormonal Response to a Mixed-Meal Challenge After Reversal of Gastric Bypass for Hypoglycemia
Lee, C. J., Brown, T., Magnuson, T. H., Egan, J. M., Carlson, O., & Elahi, D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1151 · Cited by 65
Patti, M., Li, P., & Goldfine, A. B. (2015) · Obesity · doi:10.1002/oby.21043 · Cited by 63
Kim, S. H., Liu, T. C., Abbasi, F., Lamendola, C. A., Morton, J. M., Reaven, G. M., & McLaughlin, T. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9893-8 · Cited by 62
Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia
Mathavan, V. K., Arregui, M., Davis, C., Singh, K., Patel, A., & Meacham, J. (2010) · Surgical Endoscopy · doi:10.1007/s00464-010-1001-6 · Cited by 61
Ceppa, E., Ceppa, D., Omotosho, P., Dickerson, J. A., Park, C. W., & Portenier, D. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.08.008 · Cited by 58
Permutt, M. A. (1976) · Diabetes · doi:10.2337/diab.25.8.719 · Cited by 58
González-González, A., Delgado‐Rodríguez, M., & Fraga-Fuentes, M. D. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.05.010 · Cited by 50
Hypoglycaemia following gastric bypass surgery—diabetes remission in the extreme?
Patti, M., & Goldfine, A. B. (2010) · Diabetologia · doi:10.1007/s00125-010-1884-8 · Cited by 45
Pigeyre, M., Vaurs, C., Raverdy, V., Hanaire, H. P., Ritz, P., & Pattou, F. N. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.12.004 · Cited by 42
Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient
Guseva, N., Phillips, D., & Mordes, J. P. (2010) · Endocrine Practice · doi:10.4158/ep09110.crr · Cited by 35
Padoin, A. V., Neto, M. G., Moretto, M., Barancelli, F. T., Schroer, C. E., & Mottin, C. C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9943-2 · Cited by 34
Mordes, J., & Alonso, L. C. (2015) · Endocrine Practice · doi:10.4158/ep14118.or · Cited by 23
Post-gastric-bypass hypoglycemia successfully treated with alpha-glucosidase inhibitor therapy.
Frankhouser, S. Y., Ahmad, A., Perilli, G., Quintana, B., & Vengrove, M. (2013) · Endocrine Practice · doi:10.4158/ep12281.ra · Cited by 21
Group for the Study of Obesity of the Spanish Endocrinology and Nutrition Society (SEEN), Caixàs, A., Lecube, A., Morales, M.-J., Calañas, A., Moreiro, J., Cordido, F., Díaz, M.-J., Masmiquel, L., Moreno, B., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0791-0 · Cited by 20
Self-citationEffect of calcium antagonists on reactive hypoglycemia associated with hyperinsulinemia
Sanke, T., Nanjo, K., Kondo, M., Nishi, M., Moriyama, Y., & Miyamura, K. (1986) · Metabolism · doi:10.1016/0026-0495(86)90055-7 · Cited by 17
Case report subtotal pancreatectomy as treatment for severe hypoglycemia after gastric bypass
Bray, B. F. G., Peromingo, R., Galindo, J., Arrieta, F., Sánchez, J. C. F., Vázquez, C., & Botella-Carretero, J. I. (2014) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2014.06.016 · Cited by 6
García, B. F., Peromingo, R., Galindo, J., Arrieta, F., Sánchez, J. F., Vázquez, C., & Botella-Carretero, J. I. (2014) · Endocrinologia y Nutricion · doi:10.1016/j.endonu.2014.04.001 · Cited by 2
Hypoglycemia after Roux-en-Y gastric bypass surgery
Molina, M., García, J., Civera, M., Ortega, J., Martínez-Valls, J. F., Martínez‐Hervás, S., Real, J. T., & Carmena, R. (2011) · Endocrinología y Nutrición (English Edition) · doi:10.1016/s2173-5093(11)70044-7 · Cited by 2
Hipoglucemia tras derivación gástrica en Y de Roux
Molina, M., García, J., Civera, M., Ortega, J., Martínez-Valls, J. F., Martínez‐Hervás, S., Real, J. T., & Carmena, R. (2011) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2010.10.012 · Cited by 1
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Mechanisms of action of glucagon-like peptide 1 in the pancreas
Doyle, M. E., & Egan, J. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.007 · Cited by 702
Jensen, R. T., Cadiot, G., Brandi, M. L., de Herder, W. W., Kaltsas, G., Komminoth, P., Scoazec, J., Salazar, R., Sauvanet, A., & Kianmanesh, R. (2012) · Neuroendocrinology · doi:10.1159/000335591 · Cited by 615
The role of gut hormones in glucose homeostasis
Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30076 · Cited by 628
Graaf, C. D., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., et al. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011395 · Cited by 403
Metadata
- Authors
- Vilarrasa, N., Goday, A., Rubio, M. A., Caixàs, A., Pellitero, S., Ciudin, A., Calañas, A., Botella, J. I., Bretón, I., Morales, M. J., Díaz-Fernández, M. J., García-Luna, P. P., & Lecube, A.
- Affiliations
- Bellvitge University Hospital (ES)
- Hospital del Mar Research Institute (ES)
- Hospital Del Mar (ES)
- Universitat Autònoma de Barcelona (ES)
- Venue
- Obesity Facts
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 9
- Issue
- 1
- Pages
- 41-51
- ISSN
- 1662-4025 (ISSN-L)
- 1662-4033
- PMC
- PMC5644871
- OpenAlex
- W2276159333
- Cited by
- 197
- References
- 41
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 12 · 2023: 16 · 2022: 15 · 2021: 11 · 2020: 10 · 2019: 15 · 2018: 10 · 2017: 13 · 2016: 24
- FWCI
- 22.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Obesity Facts (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by-nc)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- hyperinsulinemic hypoglycemia, bariatric surgery complications, postprandial hypoglycemia, oral glucose tolerance test, mixed meal tolerance test, octreotide, partial pancreatectomy, nesidioblastosis, Roux-en-Y gastric bypass
- MeSH terms
- Adult, Female, Glucose Tolerance Test, Humans, Hyperinsulinism, Hypoglycemia, Jejunum, Male, Middle Aged, Pancreatectomy, Registries, Retrospective Studies, Spain, Stomach, Octreotide, Incidence, Nesidioblastosis, Bariatric Surgery
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