The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Digoxin in Heart Failure with a Reduced Ejection Fraction: A Risk Factor or a Risk Marker?
Abstract
Digoxin is one of the oldest compounds used in cardiovascular medicine. Nevertheless, its mechanism of action and most importantly its clinical utility have been the subject of an endless dispute. Positive inotropic and neurohormonal modulation properties are attributed to digoxin, and it was the mainstay of heart failure therapeutics for decades. However, since the institution of β-blockers and aldosterone antagonists as part of modern heart failure medical therapy, digoxin prescription rates have been in free fall. The fact that digoxin is still listed as a valid therapeutic option in both American and European heart failure guidelines has not altered clinicians' attitude towards the drug. Since the publication of original Digitalis Investigation Group trial data, a series of reports based predominately on observational studies and post hoc analyses have raised concerns about the clinical efficacy and long-term safety of digoxin. In the present review, we will attempt a critical appraisal of the available clinical evidence regarding the efficacy and safety of digoxin in heart failure patients with a reduced ejection fraction. The methodological issues, strengths, and limitations of individual studies will be highlighted.
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2013 ACCF/AHA Guideline for the Management of Heart Failure
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Ahmed, A., Jorna, T., & Bhandari, S. (2016) · Nephron · doi:10.1159/000447068 · Cited by 11,717
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
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The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
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Cited by
Cleland, J. G. F., Bunting, K. V., Flather, M. D., Altman, D. G., Holmes, J., Coats, A. J. S., Manzano, L., McMurray, J. J. V., Ruschitzka, F., van Veldhuisen, D. J., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx564 · Cited by 659
Ahmed, A., Rich, M. W., Fleg, J. L., Zile, M. R., Young, J. B., Kitzman, D. W., Love, T. E., Aronow, W. S., Adams, K. F., & Gheorghiade, M. (2006) · Circulation · doi:10.1161/circulationaha.106.628347 · Cited by 605
Titration of medical therapy for heart failure with reduced ejection fraction
Greene, S. J., Fonarow, G. C., DeVore, A. D., Sharma, P. P., Vaduganathan, M., Albert, N. M., Duffy, C. I., Hill, C. L., McCague, K., Patterson, J. H., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.02.015 · Cited by 500
Devereaux, P. J., Beattie, W. S., Choi, P. T.-L., Badner, N. H., Guyatt, G. H., Villar, J. C., Cinà, C. S., Leslie, K., Jacka, M. J., Montori, V. M., et al. (2005) · BMJ · doi:10.1136/bmj.38503.623646.8f · Cited by 438
The vulnerable phase after hospitalization for heart failure
Greene, S. J., Fonarow, G. C., Vaduganathan, M., Khan, S. S., Butler, J., & Gheorghiade, M. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.14 · Cited by 406
Metadata
- Authors
- Konstantinou, D. M., Karvounis, H., & Giannakoulas, G.
- Venue
- Cardiology
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 134
- Issue
- 3
- Pages
- 311-319
- ISSN
- 0008-6312 (ISSN-L)
- 1421-9751
- OpenAlex
- W2340731691
- Cited by
- 870
- References
- 79
- FWCI
- 45.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Konstantinou, D. M., Karvounis, H., & Giannakoulas, G. (2016). Digoxin in Heart Failure with a Reduced Ejection Fraction: A Risk Factor or a Risk Marker? Cardiology. https://doi.org/10.1159/000444078
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
