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Cited by 11,717

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

Ahmed, Aimun, Jorna, Tom, Bhandari, Sunil·2016·Nephron
DOI 10.1159/000447068
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Abstract

Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor antagonists (ARB) are commonly used in patients with early CKD, but their value in advanced CKD (estimated GFR (eGFR) ≤30 ml/min/1.73 m 2) is unknown. There remains a debate about the omission of ACEi/ARB in patients with advanced CKD and their use in association with CVD or heart failure. Does the potential gain in eGFR with ACEi/ARB cessation outweigh the potential adverse cardiovascular outcomes? This paper reviews the current literature that addresses this issue. Several controversies are discussed. Although lowering BP reduces cardiovascular events, evidence suggests that ACEi/ARBs are not superior to other antihypertensive agents. There are no studies assessing the benefits of ACEi/ARB therapy in cardiovascular risk reduction in advanced non-dialysis CKD. The STOP ACEi trial will strengthen the evidence base and shed light on the potential merits and dangers of ACEi/ARB use in advanced CKD on renal function and cardiovascular outcomes.

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Metadata

Authors
Ahmed, A., Jorna, T., & Bhandari, S.
Venue
Nephron
Publisher
S. Karger AG
Published
2016
Volume
133
Issue
3
Pages
147-158
ISSN
  • 1660-8151 (ISSN-L)
  • 2235-3186
DOI
10.1159/000447068
OpenAlex
W2475261460
Cited by
11,717
References
24
FWCI
957.97
Type
journal article
Language
en
Open access
closed
Licence

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CoChat. (2026). Citation check: Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease? https://app.cochat.ai/papers/10.1159/000447068
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Ahmed, A., Jorna, T., & Bhandari, S. (2016). Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease? Nephron. https://doi.org/10.1159/000447068

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.