The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Transient Efficacy of Tofacitinib in Alopecia Areata Universalis
Open accessAbstract
Alopecia areata is a common autoimmune disorder that targets hair follicles. Swarms of lymphocytes surround the basis of the follicles, inducing loss of pigmented terminal hair and subsequently inhibit further hair growth. Depending on the extent of involvement, alopecia areata can be associated with a dramatic reduction of quality of life. Currently, no targeted treatment option is available, and topical immune therapies or immunosuppressive drugs are typically used with mixed success. Recently, several cases of alopecia areata responding to Janus kinase inhibitors were published. Here, we report on a businessman with alopecia areata universalis who was treated with tofacitinib. We observed initial signs of hair regrowth in the same timeframe as previously reported, but efficacy quickly waned again, leading to renewed effluvium. Thus, even though tofacitinib and ruxolitinib are a promising new treatment option, we have yet to learn more about their potential role in each particular patient's individual treatment strategy.
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Cites
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Cited by
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
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IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting
Moschen, A. R., Tilg, H., & Raine, T. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0084-8 · Cited by 473
Genetics of Inflammatory Bowel Diseases
McGovern, D. P. B., Kugathasan, S., & Cho, J. H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.001 · Cited by 431
Metadata
- Authors
- Anzengruber, F., Maul, J.-T., Kamarachev, J., Trüeb, R. M., French, L. E., & Navarini, A. A.
- Venue
- Case Reports in Dermatology
- Publisher
- S. Karger AG
- Published
- 2016-04-22
- Volume
- 8
- Issue
- 1
- Pages
- 102-106
- ISSN
- 1662-6567
- OpenAlex
- W2339287040
- Cited by
- 304
- References
- 70
- FWCI
- 58.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Anzengruber, F., Maul, J.-T., Kamarachev, J., Trüeb, R. M., French, L. E., & Navarini, A. A. (2016). Transient Efficacy of Tofacitinib in Alopecia Areata Universalis. Case Reports in Dermatology. https://doi.org/10.1159/000445182
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