Increased Expression of the Receptor for Advanced Glycation End-Products (RAGE) Is Associated with Advanced Breast Cancer Stage
Abstract
Background: The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. Methods: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. Results: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). Conclusions: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression.
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RAGE is highly upregulated in metastatic and aggressive breast, ovarian, and pancreatic cancer, acting as a promotor of the progression of premalignant precursors to invasive carcinoma.
“RAGE is highly upregulated in metastatic and aggressive breast, ovarian, and pancreatic cancer, acting as a promotor of the progression of premalignant precursors to invasive carcinoma88,89.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [89]
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- Authors
- Nankali, M., Karimi, J., Goodarzi, M. T., Saidijam, M., Khodadadi, I., Razavi, A. N. E., & Rahimi, F.
- Affiliations
- Hamedan University of Medical Sciences (IR)
- Venue
- Oncology Research and Treatment
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 39
- Issue
- 10
- Pages
- 622-628
- ISSN
- 2296-5262 (ISSN-L)
- 2296-5270
- OpenAlex
- W2520595550
- Cited by
- 53
- References
- 35
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 13 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 3
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncology Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hamadan University of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- receptor for advanced glycation end products, RAGE, breast cancer, tumor stage, triple-negative breast cancer, lymph node metastasis, tumor size, biomarkers, gene overexpression, tumor progression
- MeSH terms
- Receptor for Advanced Glycation End Products, Aged, Aged, 80 and over, Breast Neoplasms, Female, Humans, Middle Aged, Neoplasm Staging, Risk Factors, Sensitivity and Specificity, Biomarkers, Tumor, Reproducibility of Results, Up-Regulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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