Psychosocial Factors and Comorbidity Associated with Suicide Attempts: Findings in Patients with Bipolar Disorder
Abstract
Background: Suicidal attempts occur more frequently in patients with bipolar disorder compared to other mood disorders. The goal of this study is to identify psychosocial factors and comorbidity associated with this serious and life-threatening behavior. Sampling and Methods: Subjects were 121 patients evaluated and treated at a university outpatient psychiatric clinic. The patients' charts were examined to determine history of suicide attempts, demographic and psychosocial variables, and comorbid symptoms. Results: Forty-one percent of the subjects had attempted suicide. Patients who were younger at onset of illness (p = 0.02) and those who had been abused (p = 0.003) were more likely to attempt suicide. Suicide attempts were also more common in subjects with a history of alcohol abuse (p = 0.003) and those with psychotic symptoms (p = 0.02). Conclusions: Based on the results of this study, it is recommended that increased emphasis be placed on the psychosocial history and comorbid symptoms in patients with bipolar disorder. While asking about previous suicide attempts is the most accurate way to predict suicidal behavior, age of onset, past abuse, and overuse of alcohol may also be helpful. Since suicidal behavior in patients with bipolar disorder is relatively common, intensified efforts to predict this behavior may be life-saving.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · see citing works
Nanni, V., Uher, R., & Danese, A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020335 · Cited by 1,480 · see citing works
Suicide and Attempted Suicide in Bipolar Disorder: A Systematic Review of Risk Factors
Hawton, K., Sutton, L., Haw, C., Sinclair, J., & Harriss, L. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0604 · Cited by 467 · see citing works
Epidemiology of suicide in bipolar disorders: a systematic review of the literature
Pompili, M., Gonda, X., Serafini, G., Innamorati, M., Sher, L., Amore, M., Rihmer, Z., & Girardi, P. (2013) · Bipolar Disorders · doi:10.1111/bdi.12087 · Cited by 359 · see citing works
Leverich, G. S., Altshuler, L. L., Frye, M. A., Suppes, T. M., Keck, P. E., McElroy, S. L., Denicoff, K. D., Obrocea, G. V., Nolen, W. A., Kupka, R., et al. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0503 · Cited by 354 · see citing works
Angst, J., Angst, F., Gerber-Werder, R., & Gamma, A. (2005) · Archives of Suicide Research · doi:10.1080/13811110590929488 · Cited by 317 · see citing works
Oquendo, M. A., Currier, D., & Mann, J. J. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00829.x · Cited by 297 · see citing works
Suicide risk in bipolar patients: the role of co‐morbid substance use disorders
Dalton, E. J., Cate‐Carter, T. D., Mundo, E., Parikh, S. V., & Kennedy, J. L. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00017.x · Cited by 275 · see citing works
Jamison, K. R. (2019) · Routledge eBooks · doi:10.4324/9781315054308-12 · Cited by 265 · see citing works
Kanwar, A., Malik, S., Prokop, L. J., Sim, L. A., Feldstein, D., Wang, Z., & Murad, M. H. (2013) · Depression and Anxiety · doi:10.1002/da.22074 · Cited by 263 · see citing works
Bipolar disorders and suicidal behaviour
Rihmer, Z., & Kiss, K. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.4.s1.3.x · Cited by 215 · see citing works
Ford, J. D., & Gómez, J. M. (2015) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2015.989563 · Cited by 199 · see citing works
Night falls fast: understanding suicide
(2000) · Choice Reviews Online · doi:10.5860/choice.37-4175 · Cited by 189 · see citing works
Risk of suicide attempt and suicide death in patients treated for bipolar disorder 1
Simon, G. E., Hunkeler, E. M., FIREMAN, B. H., Lee, J. Y., & Savarino, J. E. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00408.x · Cited by 168 · see citing works
Fulginiti, A., Pahwa, R., Frey, L. M., Rice, E. R. W., & Brekke, J. S. (2015) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12224 · Cited by 102 · see citing works
Suicide attempts in major depressive episode: evidence from the BRIDGE ‐ II ‐Mix study
Popović, D., Vieta, E., Azorin, J., Angst, J., Bowden, C. L., Mosolov, S. N., Young, A. H., & Perugi, G. (2015) · Bipolar Disorders · doi:10.1111/bdi.12338 · Cited by 101 · see citing works
Bipolar disorder. III: Harm avoidance a risk factor for suicide attempts
Engström, C., Brändström, S., Sigvardsson, S., Cloninger, C. R., & Nylander, P. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00101.x · Cited by 90 · see citing works
Suicidal attempts in bipolar disorder: results from an observational study (EMBLEM)
Bellivier, F., Yon, L., Luquiens, A., Azorin, J., Bertsch, J., Gerard, S., Reed, C. C., & Lukasiewicz, M. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00926.x · Cited by 83 · see citing works
Bipolar disorder and suicide: Research synthesis and clinical translation
McIntyre, R. S., Muzina, D. J., Kemp, D. E., Blank, D., Woldeyohannes, H. O., Lofchy, J., Soczynska, J. K., Banik, S., & Konarski, J. Z. (2008) · Current Psychiatry Reports · doi:10.1007/s11920-008-0012-7 · Cited by 80 · see citing works
Attempted Suicide in Bipolar Disorder: Risk Factors in a Cohort of 6086 Patients
Tidemalm, D., Haglund, A., Karanti, A., Landén, M., & Runeson, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094097 · Cited by 79 · see citing works
Assessment and treatment of suicide risk in bipolar disorders
Pompili, M., Rihmer, Z., Innamorati, M., Lester, D., Girardi, P., & Tatarelli, R. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.9.1.109 · Cited by 79 · see citing works
Marangell, L. B., Dennehy, E. B., Wisniewski, S. R., Bauer, M. S., Mayahara, S., Allen, M. H., Martínez, M., Jurdi, R. K. A., & Thase, M. E. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0605 · Cited by 77 · see citing works
Suicidal Behavior in Bipolar Disorder
Neves, F. S., Malloy‐Diniz, L. F., & Corrêa, H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04037 · Cited by 71 · see citing works
Raja, M. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.02.001 · Cited by 69 · see citing works
Risk Factors of Attempted Suicide in Bipolar Disorder
Cassidy, F. (2011) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.2010.00007.x · Cited by 64 · see citing works
Clinical and Cognitive Correlates of Suicide Attempts in Bipolar Disorder
Gilbert, A. M., Garno, J. L., Braga, R. J., Shaya, Y., Goldberg, T. E., Malhotra, A. K., & Burdick, K. E. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06410 · Cited by 57 · see citing works
Assessment of Risk Factors Related to Suicide Attempts in Patients With Bipolar Disorder
Song, J. Y., Yu, H. Y., Kim, S. H., Hwang, S. S., Cho, H. S., Kim, Y. S., Ha, K., & Ahn, Y. M. (2012) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3182718a07 · Cited by 39 · see citing works
A Descriptive Analysis of Factors Leading to a 1-Year Remission in Bipolar Disorder
RAPPORT, D. J., Kaplish, D., McGrady, A. V., McGinnis, R. A., Whearty, K., Thomas, M., & Fine, T. H. (2015) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000102 · Cited by 4 · see citing works
Self-citationPsychosocial Factors Associated With Recovery In Bipolar Disorder
RAPPORT, D. J., Lynch, D. J., McGrady, A. V., et al. (2015) · Journal of Depression And Therapy · doi:10.14302/issn.2476-1710.jdt-15-762 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Baldini, V., Gottardi, C., Di Stefano, R., Rindi, L. V., Pazzocco, G., Varallo, G., Purgato, M., De Ronchi, D., Barbui, C., & Ostuzzi, G. (2025) · European Psychiatry · doi:10.1192/j.eurpsy.2025.2452 · Cited by 41 · see citing works
- Authors
- McGrady, A., Lynch, D., & Rapport, D.
- Affiliations
- University of Toledo (US)
- Venue
- Psychopathology
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 50
- Issue
- 2
- Pages
- 171-174
- ISSN
- 0254-4962 (ISSN-L)
- 1423-033X
- OpenAlex
- W2582610694
- Cited by
- 19
- References
- 29
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 4 · 2017: 2
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- suicide attempts, bipolar disorder, psychosocial risk factors, comorbidities, age of onset, childhood abuse, alcohol abuse, psychotic symptoms, suicide risk prediction
- MeSH terms
- Adult, Alcoholism, Bipolar Disorder, Female, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Suicide, Attempted, Comorbidity, Age of Onset, Mood Disorders, Substance-Related Disorders, Suicidal Ideation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review