The effect of thalidomide on a prosimian: the greater galago (Galago crassicaudatus)
Abstract
A Prosimian, the greater galago, showed no teratogenic response when thalidomide was administered between days 16 through 42 of pregnancy, a period which completely covers the period of limb bud formation.
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Species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity.
“Moreover, it has been shown that species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity (Butler, 1977; Heger et al., 1988; Ingalls et al., 1964; Vickers, 1967)”
From Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) · cites this paper as Butler, 1977
The only non-human primate known to be insensitive to thalidomide-induced embryopathies, the greater bush baby, harbors an isoleucine in the critical CRBN V388 position, while all sensitive non-human primates and rabbits harbor the conserved valine.
“Of note, the only non-human primate known to be insensitive to thalidomide-induced embryopathies, the greater bush baby, also harbors an isoleucine in the critical CRBN V388 position (Butler, 1977), while all sensitive non-human primates and rabbits harbor the conserved valine (Figure 5A).”
From Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) · cites this paper as Butler, 1977
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Donovan, K. A., An, J., Nowak, R. P., Yuan, J. C., Fink, E. C., Berry, B. C., Ebert, B. L., & Fischer, E. S. (2018) · eLife · doi:10.7554/elife.38430 · Cited by 509 · see citing works
“Moreover, it has been shown that species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity (Butler, 1977; Heger et al., 1988; Ingalls et al., 1964; Vickers, 1967), which suggests an underlying genetic difference between species, more likely to be present in a specific substrate ra…”
BackgroundCrbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice
Fink, E. C., McConkey, M., Adams, D. N., Haldar, S. D., Kennedy, J. A., Guirguis, A. A., Udeshi, N. D., Mani, D. R., Chen, M., Liddicoat, B., et al. (2018) · Blood · doi:10.1182/blood-2018-05-852798 · Cited by 131 · see citing works
Assessment of the effectiveness of animal developmental toxicity testing for human safety
Newman, L. M., Johnson, E. M., & STAPLES, R. E. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90025-3 · Cited by 65 · see citing works
Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus
Merker, H., Heger, W., Sames, K., St�rje, H., & Neubert, D. (1988) · Archives of Toxicology · doi:10.1007/bf00316631 · Cited by 53 · see citing works
Nonhuman Primates and Teratological Research
Hendrickx, A. G., & Binkerd, P. E. (1990) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.1990.tb00417.x · Cited by 45 · see citing works
Embryotoxic effects of thalidomide derivatives in the non-human primateCallithrix jacchus
Klug, S., Felies, A., Stürje, H., Nogueira, A. C. D. A., Neubert, R. T., & FRANKUS, E. (1994) · Archives of Toxicology · doi:10.1007/s002040050055 · Cited by 44 · see citing works
The History and Implications of Testing Thalidomide on Animals
Greek, R., Shanks, N., & Rice, M. J. (2011) · The Journal of Philosophy Science & Law · doi:10.5840/jpsl20111133 · Cited by 33 · see citing works
Nogueira, A. C. M. D. A., Neubert, R. T., Felies, A., Jacob-Müller, U., FRANKUS, E., & Neubert, D. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02293-7 · Cited by 23 · see citing works
Khera, K. S. (1984) · Springer eBooks · doi:10.1007/978-1-4615-7314-2_10 · Cited by 19 · see citing works
Peculiarities and Possible Mode of Actions of Thalidomide
Neubert, R. T., & Neubert, D. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60447-8_2 · Cited by 18 · see citing works
Developmental Toxicity and Nonhuman Primates
Hendrickx, A. G., Binkerd, P. E., & Rowland, J. M. (1983) · Springer eBooks · doi:10.1007/978-1-4615-7311-1_6 · Cited by 16 · see citing works
Thalidomide-induced limb malformations: an update and reevaluation
Collins, M. D., & Scott, W. J. (2025) · Archives of Toxicology · doi:10.1007/s00204-024-03930-z · Cited by 10 · see citing works
Primate teratology: selection of species and future use
Hendrickx, A. G., & Binkerd, P. E. (1979) · Springer eBooks · doi:10.1007/978-94-011-6651-5_1 · Cited by 7 · see citing works
Kowalski, T. W., Caldas-Garcia, G. B., Gomes, J. D. A., Fraga, L. R., Schüler‐Faccini, L., Recamonde‐Mendoza, M., Paixão‐Côrtes, V. R., & Vianna, F. S. L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.680217 · Cited by 5 · see citing works
Figg, W. D., Reed, E., Green, S. J., & Pluda, J. M. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-453-5_24 · Cited by 3 · see citing works
(2000) · CRC Press eBooks · doi:10.3109/9780203909904-4 · Cited by 2 · see citing works
Investigating the Mechanism and Species-Specificity of Thalidomide Derivatives
Fink, E. C. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Authors
- Butler, H.
- Corresponding author
- Butler, H.
- Venue
- Journal of Medical Primatology
- Publisher
- S. Karger AG
- Published
- 1977
- Volume
- 6
- Issue
- 5
- Pages
- 319-324
- ISSN
- 0047-2565 (ISSN-L)
- 1600-0684
- OpenAlex
- W2416011325
- Cited by
- 17
- References
- 0
- Citations by year
- 2025: 1 · 2021: 1 · 2018: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Primatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- thalidomide, teratogenicity, greater galago, Galago crassicaudatus, prosimians, limb bud formation, prenatal drug exposure, pregnancy, limb malformations
- MeSH terms
- Abnormalities, Drug-Induced, Animals, Female, Galago, Pregnancy, Thalidomide
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