The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?
Open accessAbstract
Healing and regeneration of bone injuries, particularly those that are associated with large bone defects, are a complicated process. There is growing interest in the application of osteoinductive and osteogenic growth factors and mesenchymal stem cells (MSCs) in order to significantly improve bone repair and regeneration. MSCs are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types, such as preosteogenic chondroblasts and osteoblasts. The effectiveness of MSC therapy is dependent on several factors, including the differentiating state of the MSCs at the time of application, the method of their delivery, the concentration of MSCs per injection, the vehicle used, and the nature and extent of injury, for example. Tissue engineering and regenerative medicine, together with genetic engineering and gene therapy, are advanced options that may have the potential to improve the outcome of cell therapy. Although several in vitro and in vivo investigations have suggested the potential roles of MSCs in bone repair and regeneration, the mechanism of MSC therapy in bone repair has not been fully elucidated, the efficacy of MSC therapy has not been strongly proven in clinical trials, and several controversies exist, making it difficult to draw conclusions from the results. In this review, we update the recent advances in the mechanisms of MSC action and the delivery approaches in bone regenerative medicine. We will also review the most recent clinical trials to find out how MSCs may be beneficial for treating bone defects.
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1 retracted
Induced Endothelial Cells Enhance Osteogenesis and Vascularization of Mesenchymal Stem Cells
Tao, J., Sun, Y., Wang, Q., & Liu, C. (2009) · Cells Tissues Organs · doi:10.1159/000218139 · Cited by 29
RetractedHuman Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P., De Ugarte, D. A., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,664
On the mechanisms of biocompatibility
Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Bone Tissue Engineering: Recent Advances and Challenges
Amini, A. R., Laurencin, C. T., & Nukavarapu, S. P. (2012) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v40.i5.10 · Cited by 2,336
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
Recent advances in bone tissue engineering scaffolds
Bose, S., Roy, M., & Bandyopadhyay, A. (2012) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.07.005 · Cited by 2,206
Murphy, C. M., Haugh, M. G., & O'Brien, F. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.063 · Cited by 2,056
Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P., & Prockop, D. J. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.003 · Cited by 1,898
Horwitz, E. M., Prockop, D. J., Fitzpatrick, L. A., Koo, W. W. K., Gordon, P. L., Neel, M., Sussman, M., Orchard, P., Marx, J. C., Pyeritz, R. E., et al. (1999) · Nature Medicine · doi:10.1038/6529 · Cited by 1,824
Cited by
Mesenchymal stem cells: Amazing remedies for bone and cartilage defects
Kangari, P., Talaei-Khozani, T., Razeghian-Jahromi, I., & Razmkhah, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02001-1 · Cited by 286
Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis
Zhu, J., Liu, Y., Chen, C., Chen, H., Huang, J., Luo, Y., Zhao, K., Chen, D., Xu, Z., Li, W., et al. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.11.004 · Cited by 33
Blood flow in the scaphoid is improved by focused extracorporeal shock wave therapy
Schleusser, S., Song, J., Stang, F. H., Mailaender, P., Kraemer, R., & Kisch, T. (2020) · Clinical Orthopaedics & Related Research · doi:10.1097/corr.0000000000000993 · Cited by 25
Man, K., Brunet, M. Y., Lees, R., Peacock, B., & Cox, S. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087564 · Cited by 25
Metadata
- Authors
- Oryan, A., Kamali, A., Moshiri, A., & Baghaban Eslaminejad, M.
- Venue
- Cells Tissues Organs
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 204
- Issue
- 2
- Pages
- 59-83
- ISSN
- 1422-6405 (ISSN-L)
- 1422-6421
- OpenAlex
- W2683627480
- Cited by
- 353
- References
- 157
- FWCI
- 17.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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