The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Low FT4 Concentrations around the Start of Recombinant Human Growth Hormone Treatment: Predictor of Congenital Structural Hypothalamic-Pituitary Abnormalities?
Abstract
Background: Growth hormone (GH) treatment may unmask central hypothyroidism (CeH). This was first observed in children with GH deficiency (GHD), later also in adults with GHD due to acquired “organic” pituitary disease. We hypothesized that newly diagnosed CeH in children after starting GH treatment for nonacquired, apparent isolated GHD points to congenital “organic” pituitary disease. Methods: Nationwide, retrospective cohort study including all children with nonacquired GHD between 2001 and 2011 in The Netherlands. The prevalence of CeH, hypothalamic-pituitary (HP) abnormalities, and neonatal congenital hypothyroidism screening results were evaluated. Results: Twenty-three (6.3%) of 367 children with apparent isolated GHD were prescribed LT4 for presumed CeH within 2 years after starting GH treatment. Similarly to children already diagnosed with multiple pituitary hormone deficiency, 75% of these 23 had structural HP abnormalities. In children not prescribed LT4, low pre- or post-GH treatment FT4 concentrations were also associated with structural HP abnormalities. Neonatal screening results of only 4 of the 23 children could be retrieved. Conclusion: In children with nonacquired, apparent isolated GHD, a diagnosis of CeH after, or a low FT4 concentration around the start of GH treatment, is associated with congenital structural HP abnormalities, i.e., “organic” pituitary disease. Neonatal values could not be judged reliably.
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“Central hypothyroidism can be missed when free T4 serum concentrations are in the lower half of the reference range (166-168).”
From Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity (2025) · cites this paper as [166]
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Sun, Y., Bak, B., Schoenmakers, N., van Trotsenburg, A. S. P., Oostdijk, W., Voshol, P., Cambridge, E., White, J. K., le Tissier, P., Gharavy, S. N. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2453 · Cited by 217
Self-citationNeonatal Detection of Congenital Hypothyroidism of Central Origin
van Tijn, D. A., de Vijlder, J. J. M., Verbeeten, B., Verkerk, P. H., & Vulsma, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2444 · Cited by 139
Mechanisms related to the pathophysiology and management of central hypothyroidism
Yamada, M., & Mori, M. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0995 · Cited by 114
Kempers, M. J. E., Lanting, C. I., van Heijst, A. F. J., van Trotsenburg, A. S. P., Wiedijk, B. M., de Vijlder, J. J. M., & Vulsma, T. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0058 · Cited by 109
The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men*
GRUNFELD, C., SHERMAN, B. M., & CAVALIERI, R. R. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-5-1111 · Cited by 108
Behan, L. A., Monson, J. P., & Agha, A. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03815.x · Cited by 53
Cited by
Van Uytfanghe, K., Ehrenkranz, J., Halsall, D., Hoff, K., Loh, T. P., Spencer, C. A., Köhrle, J., & ATA Thyroid Function Tests Writing Group (2023) · Thyroid® · doi:10.1089/thy.2023.0169 · Cited by 100
Naafs, J. C., Heinen, C. A., Zwaveling-Soonawala, N., van der Schoor, S. R. D., van Tellingen, V., Heijboer, A. C., Fliers, E., Boelen, A., & van Trotsenburg, A. S. P. (2020) · Thyroid® · doi:10.1089/thy.2019.0779 · Cited by 21
Self-citationvan Santen, H. M., & Müller, H. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf025 · Cited by 21
Mortality in Children With Early-Detected Congenital Central Hypothyroidism
Zwaveling-Soonawala, N., Naafs, J. C., Verkerk, P. H., & van Trotsenburg, A. S. P. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00629 · Cited by 15
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Metadata
- Authors
- van Iersel, L., van Santen, H. M., Zandwijken, G. R. J., Zwaveling-Soonawala, N., Hokken-Koelega, A. C. S., & van Trotsenburg, A. S. P.
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2018
- Volume
- 89
- Issue
- 2
- Pages
- 98-107
- ISSN
- 1663-2818
- 1663-2826
- Cited by
- 23
- References
- 6
- Language
- en
- Licence
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- creativecommons.org/licenses/by-nc-nd/4.0/ (tdm)
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- van Iersel, L., van Santen, H. M., Zandwijken, G. R. J., Zwaveling-Soonawala, N., Hokken-Koelega, A. C. S., & van Trotsenburg, A. S. P. (2018). Low FT4 Concentrations around the Start of Recombinant Human Growth Hormone Treatment: Predictor of Congenital Structural Hypothalamic-Pituitary Abnormalities? Hormone Research in Paediatrics. https://doi.org/10.1159/000486033
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