Association of Fatigue Intensification with Cognitive Impairment during Radiation Therapy for Prostate Cancer

Feng, Li Rebekah; Espina, Alexandra; Saligan, Leorey N.

doi:10.1159/000487081

Cited by 24Cancer-related cognitive impairment studiesCancer survivorship and careFrailty in Older Adults

Association of Fatigue Intensification with Cognitive Impairment during Radiation Therapy for Prostate Cancer

Open access

Feng, Li Rebekah, Espina, Alexandra, Saligan, Leorey N.·2018·Oncology

DOI 10.1159/000487081PMC PMC6067654

Open this paper in CoChat — free account Open PDF

Abstract

Purpose: Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. Methods: A total of 36 participants were enrolled and followed up at baseline, 24 h, 7 days, 14 days after EBRT initiation, at midpoint, and at completion of EBRT. Fatigue was measured by self-report using the Functional Assessment of Cancer Therapy – Fatigue (FACT-F), and cognitive impairment by the Computer Assessment of Mild Cognitive Impairment (CAMCI®). Results: Subjects with increased fatigue during EBRT reported a significant decline in cognitive function and had difficulties with CAMCI®’s route finding and item recall tasks during EBRT. Increased fatigue during EBRT was associated with perceived cognitive difficulties in executive function and recognition memory, but not with attention or verbal memory. Conclusions: Our results suggest that there might be specific cognitive domains that are associated with increased fatigue during EBRT. These findings will provide important information for targeting specific cognitive domains using pharmacotherapy or behavioral interventions. CAMCI® is a valuable tool for psycho social providers to detect subtle cognitive impairment in fatigued cancer patients in a clinical setting.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1159/000487081

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Previous studies have reported negative side effects of fatigue, sleep disturbance, anxiety and depression among men diagnosed with PC during and following RT.
“Previous studies have reported the negative side effects of fatigue, sleep disturbance, anxiety and depression among men diagnosed with PC during and following RT.3,8-11”
From Implementation Readiness and Initial Effects of a Brief Mindfulness Audio Intervention Compared With a Brief Music Control During Daily Radiation Therapy for Prostate Cancer: A Randomized Pilot Study. (2024) · cites this paper as [3]
The Introduction (page unavailable) describes fatigue as a troublesome side effect that can worsen during radiation therapy and persist after treatment. Subject Demographics reports mild anxiety and depressive symptoms before and during treatment, while Instruments says sleep disturbance was measured. The paper does not establish sleep disturbance, anxiety, and depression as negative side effects during and following radiation therapy in these men; its participants were followed only through treatment completion. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Fatigue is one of the most common, debilitating, and distressing side effects of RT reported by cancer patients.
“Fatigue is one of the most common, debilitating, and distressing side effects of RT reported by cancer patients,2-4”
From Implementation Readiness and Initial Effects of a Brief Mindfulness Audio Intervention Compared With a Brief Music Control During Daily Radiation Therapy for Prostate Cancer: A Randomized Pilot Study. (2024) · cites this paper as [3]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system.
Yellen, S. B., Cella, D. F., Webster, K., Blendowski, C., & Kaplan, E. (1997) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(96)00274-6 · Cited by 1,964 · see citing works
Development of Short Forms From the PROMIS™ Sleep Disturbance and Sleep-Related Impairment Item Banks
Yu, L., Buysse, D. J., Germain, A., Moul, D. E., Stover, A., Dodds, N. E., Johnston, K. L., & Pilkonis, P. A. (2012) · Behavioral Sleep Medicine · doi:10.1080/15402002.2012.636266 · Cited by 1,241 · see citing works
Severity classification on the Hamilton depression rating scale
Zimmerman, M., Martinez, J. H., Young, D., Chelminski, I., & Dalrymple, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.028 · Cited by 1,199 · see citing works
Cancer-Related Fatigue, Version 2.2015
Berger, A. M., Mooney, K. H., Alvarez-Perez, A., BREITBART, W. S., Carpenter, K. M., Cella, D. F., Cleeland, C. S., Dotan, E., Eisenberger, M. A., Escalante, C. P., et al. (2015) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2015.0122 · Cited by 961 · see citing works
The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer.
Piper, B. F., Dibble, S. L., Dodd, M. J., Weiss, M. C., Slaughter, R. E., & Paul, S. M. (1998) · PubMed · Cited by 838 · see citing works
Combining Anchor and Distribution-Based Methods to Derive Minimal Clinically Important Differences on the Functional Assessment of Cancer Therapy (FACT) Anemia and Fatigue Scales
Cella, D. F., Eton, D. T., Lai, J., Peterman, A. H., & Merkel, D. E. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00529-8 · Cited by 808 · see citing works
Impairment of Cognitive Function in Women Receiving Adjuvant Treatment for High-Risk Breast Cancer: High-Dose Versus Standard-Dose Chemotherapy
van Dam, F. S. A. M., Boogerd, W. J., Schagen, S. B., Müller, M. J., Fortuyn, M. E. D., van der Wall, E., & Rodenhuis, S. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.3.210 · Cited by 764 · see citing works
Prevalence, mechanisms, and management of cancer-related cognitive impairment
Janelsins, M. C., Kesler, S. R., Ahles, T. A., & Morrow, G. R. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2013.864260 · Cited by 750 · see citing works
Minimally important differences were estimated for six Patient-Reported Outcomes Measurement Information System-Cancer scales in advanced-stage cancer patients
Yost, K. J., Eton, D. T., Garcia, S. F., & Cella, D. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.11.018 · Cited by 597 · see citing works
Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy
Koppelmans, V., Breteler, M. M. B., Boogerd, W. J., Seynaeve, C., Gundy, C. M., & Schagen, S. B. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.0189 · Cited by 551 · see citing works
Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer‐related cognitive impairment in adults
Wefel, J. S., Kesler, S. R., Noll, K. R., & Schagen, S. B. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21258 · Cited by 546 · see citing works
Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve
Ahles, T. A., Saykin, A. J., McDonald, B. C., Li, Y., Furstenberg, C. T., Hanscom, B. S., Mulrooney, T. J., Schwartz, G. N., & Kaufman, P. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.0827 · Cited by 536 · see citing works
Confronting chemobrain: an in-depth look at survivors’ reports of impact on work, social networks, and health care response
Boykoff, N., Moieni, M., & Subramanian, S. K. (2009) · Journal of Cancer Survivorship · doi:10.1007/s11764-009-0098-x · Cited by 523 · see citing works
Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis.
Cella, D. F., Yount, S., Sorensen, M., Chartash, E., Sengupta, N., & Grober, J. (2005) · PubMed · Cited by 501 · see citing works
Cognitive Function, Fatigue, and Menopausal Symptoms in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Tchen, N., Juffs, H. G., Downie, F. P., Yi, Q., Hu, H., Chemerynsky, I., Clemons, M. J., Crump, M., Goss, P. E., Warr, D. G., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.119 · Cited by 376 · see citing works
Relative to the general US population, chronic diseases are associated with poorer health-related quality of life as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS)
Rothrock, N. E., Hays, R. D., Spritzer, K. L., Yount, S., Riley, W. T., & Cella, D. F. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.012 · Cited by 351 · see citing works
Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors
Kesler, S. R., Janelsins, M. C., Koovakkattu, D., Palesh, O. G., Mustian, K. M., Morrow, G. R., & Dhabhar, F. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.017 · Cited by 313 · see citing works
Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer
de Ruiter, M. B., Reneman, L., Boogerd, W. J., Veltman, D. J., van Dam, F. S. A. M., Nederveen, A. J., Boven, E., & Schagen, S. B. (2010) · Human Brain Mapping · doi:10.1002/hbm.21102 · Cited by 306 · see citing works
Troublesome Symptoms in Cancer Survivors: Fatigue, Insomnia, Neuropathy, and Pain
Pachman, D. R., Barton, D. L., Swetz, K. M., & Loprinzi, C. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.7238 · Cited by 282 · see citing works
Impact of perceived cognitive impairment in breast cancer survivors
Ah, D. M. V., Habermann, B., Carpenter, J. S., & Schneider, B. L. (2012) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2012.06.002 · Cited by 274 · see citing works
Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study
McDonald, B. C., Conroy, S. K., Smith, D. J., West, J. D., & Saykin, A. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.007 · Cited by 223 · see citing works
Course and Predictors of Cognitive Function in Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Controlled Comparison
Gonzalez, B. D., Jim, H., Booth‐Jones, M., Small, B. J., Sutton, S. K., Lin, H., Park, J. Y., Spiess, P. E., Fishman, M., & Jacobsen, P. B. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.1963 · Cited by 212 · see citing works
A Randomized, Double-blind, Placebo-Controlled Trial of Psychostimulants for the Treatment of Fatigue in Ambulatory Patients With Human Immunodeficiency Virus Disease
BREITBART, W. S., Rosenfeld, B. D., Kaim, M., & Funesti-Esch, J. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.3.411 · Cited by 200 · see citing works
Cancer‐related fatigue and its impact on functioning
Minton, O., Berger, A. M., Barsevick, A. M., Cramp, F. L., Goedendorp, M. M., Mitchell, S. A., & Stone, P. C. (2013) · Cancer · doi:10.1002/cncr.28058 · Cited by 190 · see citing works
International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)
Weis, J., Tomaszewski, K. A., Hammerlid, E., Ignacio Arraras, J., Conroy, T., Lanceley, A., Schmidt, H., Wirtz, M., Singer, S., Pinto, M., et al. (2017) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djw273 · Cited by 182 · see citing works
Computer Assessment of Mild Cognitive Impairment
Saxton, J. A., Morrow, L. A., Eschman, A., Archer, G., Luther, J. F., & Zuccolotto, A. P. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.03.1990 · Cited by 170 · see citing works
Prevalence and Correlates of Fatigue in Long-Term Survivors of Childhood Leukemia
Meeske, K., Siegel, S. E., GLOBE, D. R., Mack, W. J., & Bernstein, L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.210 · Cited by 164 · see citing works
Association Between Androgen Deprivation Therapy and Risk of Dementia
Nead, K. T., Gaskin, G., Chester, C., Swisher-McClure, S. D., Leeper, N. J., & Shah, N. H. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.3662 · Cited by 155 · see citing works
The relationship between perceived and objective cognitive functioning in multiple sclerosis
Middleton, L. S., Denney, D. R., Lynch, S. G., & Parmenter, B. A. (2006) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2006.06.008 · Cited by 153 · see citing works
Cognitive function and fatigue after diagnosis of colorectal cancer
Vardy, J. L., Dhillon, H. M., Pond, G. R., Rourke, S. B., Xu, W., Dodd, A., Renton, C., Park, A. M.-G., Bekele, T., Ringash, J. G., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu448 · Cited by 138 · see citing works
Evaluation of a Single Dose of Ferric Carboxymaltose in Fatigued, Iron-Deficient Women – PREFER a Randomized, Placebo-Controlled Study
Favrat, B., Balck, K., Breymann, C., Hedenus, M., Keller, T., Mezzacasa, A., & Gasche, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094217 · Cited by 130 · see citing works
Chemotherapy-related cognitive impairment in older patients with cancer
Loh, K. P., Janelsins, M. C., Mohile, S. G., Holmes, H. M., Hsu, T., Inouye, S. K., Karuturi, M. S., Kimmick, G. G., Lichtman, S. M., Magnuson, A. M., et al. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.04.008 · Cited by 127 · see citing works
Cancer-Related Fatigue: Definitions and Clinical Subtypes
Piper, B. F., & Cella, D. F. (2010) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2010.0070 · Cited by 116 · see citing works
Randomized controlled pilot trial of mindfulness-based stress reduction for breast and colorectal cancer survivors: effects on cancer-related cognitive impairment
Johns, S. A., Ah, D. M. V., Brown, L. F., Beck‐Coon, K., Talib, T. L., Alyea, J. M., Monahan, P. O., Tong, Y., Wilhelm, L. R., & Giesler, R. B. (2015) · Journal of Cancer Survivorship · doi:10.1007/s11764-015-0494-3 · Cited by 112 · see citing works
Cancer, cognitive impairment, and meditation
Biegler, K. A., Alejandro Chaoul, M., & Cohen, L. (2009) · Acta Oncologica · doi:10.1080/02841860802415535 · Cited by 111 · see citing works
Assessment of cognition in mild cognitive impairment: A comparative study
Snyder, P. J., Jackson, C. E., Petersen, R. C., Khachaturian, A. S., Kaye, J. A., Albert, M., & Weıntraub, S. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.03.009 · Cited by 106 · see citing works
Perceived Cognitive Difficulties and Cognitive Test Performance as Predictors of Employment Outcomes in People with Multiple Sclerosis
Honan, C. A., Brown, R. F., & Batchelor, J. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000053 · Cited by 101 · see citing works
The Piper Fatigue Scale-12 (PFS-12): psychometric findings and item reduction in a cohort of breast cancer survivors
Reeve, B. B., Stover, A. M., Alfano, C. M., Smith, A. W., Ballard-Barbash, R. R., Bernstein, L., McTiernan, A., Baumgartner, K. B., & Piper, B. F. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2212-4 · Cited by 100 · see citing works
Test–retest bias, reliability, and regression equations for neuropsychological measures repeated over a 12–16-week period
Salinsky, M., Storzbach, D. M., Dodrill, C. B., & Binder, L. M. (2001) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617701755075 · Cited by 99 · see citing works
Fatigue, patient reported outcomes, and objective measurement of physical activity in systemic lupus erythematosus
Mahieu, M. A., Ahn, G. E., Chmiel, J. S., Dunlop, D. D., Helenowski, I., Semanik, P. A., Song, J., Yount, S., Chang, R. W., & Ramsey‐Goldman, R. (2016) · Lupus · doi:10.1177/0961203316631632 · Cited by 91 · see citing works
Neuromarkers of fatigue and cognitive complaints following chemotherapy for breast cancer: a prospective fMRI investigation
Askren, M. K., Jung, M. S., Berman, M. G., Zhang, M., Therrien, B. A., Peltier, S., Ossher, L., Hayes, D. F., Reuter‐Lorenz, P. A., & Cimprich, B. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3092-6 · Cited by 70 · see citing works
Attention network test: Assessment of cognitive function in chronic fatigue syndrome
Togo, F., Lange, G., Natelson, B. H., & Quigley, K. S. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12030 · Cited by 61 · see citing works
Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability
Neumann, M., Sterr, A., Claros-Salinas, D., Gütler, R., Ulrich, R., & Dettmers, C. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.03.024 · Cited by 56 · see citing works
Cognitive function, mood, and sleep quality in patients treated with intensity-modulated radiation therapy for nasopharyngeal cancer: a prospective study
Mo, Y.-L., Li, L., Qin, L., Zhu, X., Qu, S., Liang, X., & Wei, Z.-J. (2014) · Psycho-Oncology · doi:10.1002/pon.3542 · Cited by 49 · see citing works
Psychometric properties of the revised Piper Fatigue Scale in Dutch cancer patients were satisfactory
Dagnelie, P. C., Pijls-Johannesma, M. C. G., Pijpe, A., Boumans, B. J. E., Skrabanja, A. T. P., Lambin, P., & Kempen, G. I. J. M. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.09.015 · Cited by 39 · see citing works
Concurrent Validity of a Computer-Based Cognitive Screening Tool for Use in Adults with HIV Disease
Becker, J. T., Dew, M. A., Aizenstein, H. J., López, O. L., Morrow, L. A., & Saxton, J. A. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0051 · Cited by 32 · see citing works
Comparison of three cognitive exams in cardiac arrest survivors
Koller, A. C., Rittenberger, J. C., Repine, M. J., Morgan, P. W., Kristan, J., & Callaway, C. W. (2017) · Resuscitation · doi:10.1016/j.resuscitation.2017.04.011 · Cited by 29 · see citing works
Neuropsychological Performance in Survivors of Breast Cancer More Than 20Years After Adjuvant Chemotherapy
Meyers, C. A. (2013) · Breast Diseases A Year Book Quarterly · doi:10.1016/j.breastdis.2013.01.017 · Cited by 28 · see citing works
Rating scales in general practice depression: Psychometric analyses of the Clinical Interview for Depression and the Hamilton Rating Scale
Bech, P., Paykel, E. S., Sireling, L., & Yiend, J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.013 · Cited by 28 · see citing works
Validity and Reliability of the Hamilton Depression Rating Scale (5 Items) for Manic and Mixed Bipolar Disorders
González-Pinto, A. M., Mosquera, F., Reed, C. C., Novick, D., Barbeito, S., Vega, P., Bertsch, J., Alberich, S., & Haro, J. M. (2009) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181b3b3a0 · Cited by 25 · see citing works
NSAID Use and Incident Cognitive Impairment in a Population-based Cohort
Wichmann, M. A., Cruickshanks, K. J., Carlsson, C. M., Chappell, R. J., Fischer, M., Klein, R., Klein, R., & Schubert, C. R. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000098 · Cited by 25 · see citing works
Clinical Predictors of Fatigue in Men With Non-Metastatic Prostate Cancer Receiving External Beam Radiation Therapy
Feng, L., Chen, M., Lukkahatai, N., Hsiao, C., Kaushal, A., SECHREST, L. B., & Saligan, L. N. (2015) · Clinical journal of oncology nursing · doi:10.1188/15.cjon.744-750 · Cited by 24 · see citing works
Self-citation
Relationship between perceived cognitive dysfunction and objective neuropsychological performance in persons with rheumatoid arthritis
Shin, S. Y., Katz, P., & Julian, L. J. (2013) · Arthritis Care & Research · doi:10.1002/acr.21814 · Cited by 21 · see citing works
Perceived fatigue interference and depressed mood: comparison of chronic fatigue syndrome/myalgic encephalomyelitis patients with fatigued breast cancer survivors
Hall, D. L., Antoni, M. H., Lattie, E. G., Jutagir, D. R., Czaja, S. J., Perdomo, D. M., Lechner, S. C., Stagl, J. M., Bouchard, L. C., Gudenkauf, L. M., et al. (2015) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2015.1039289 · Cited by 15 · see citing works
Different Phenotyping Approaches Lead to Dissimilar Biologic Profiles in Men With Chronic Fatigue After Radiation Therapy
Feng, L., Dickinson, K. A., Kline, N. L., & Saligan, L. N. (2016) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2016.07.007 · Cited by 15 · see citing works
Self-citation
W472 A SINGLE 1000 MG IRON DOSE OF FERRIC CARBOXYMALTOSE IMPROVES FATIGUE IN IRON DEFICIENT, NON‐ANAEMIC PREMENOPAUSAL WOMEN – RESULTS OF THE RANDOMISED, PLACEBO‐CONTROLLED PREFER STUDY
Favrat, B., Balck, K., Gasché, C., Hedenus, M., Mezzacasa, A., Küng, C., & Breymann, C. (2012) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(12)62191-2 · Cited by 14 · see citing works
Obstructive airways disease clinical clues to diagnosis and management
Bobear, J. B. (1976) · Postgraduate Medicine · doi:10.1080/00325481.1976.11712092 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Yu L, Buysse DJ, Germain A, Moul DE, Stover A, Dodds NE, Johnston KL, Pilkonis PA: De- velopment of short forms from the PROM- IS TM Sleep Disturbance and Sleep-Related Im- pairment item banks. Behav Sleep Med 2011; 10: 6-24.

Sorted by citations

Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook
Olson, B. G., & Marks, D. L. (2019) · Cancers · doi:10.3390/cancers11050687 · Cited by 115 · see citing works
Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial
Piraux, E., Caty, G. D., Renard, L. G., Vancraeynest, D., TOMBAL, B. F., Geets, X., & Reychler, G. (2020) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-020-0259-6 · Cited by 55 · see citing works
Cognitive and motor aspects of cancer‐related fatigue
Feng, L., Regan, J. M., Shrader, J. A., Liwang, J. K., Ross, A., Maharaj, S. K., & Saligan, L. N. (2019) · Cancer Medicine · doi:10.1002/cam4.2490 · Cited by 42 · see citing works
Self-citation
Cognitive function, depression, and anxiety in patients undergoing radical prostatectomy with and without adjuvant treatment
Jarzemski, P., Brzoszczyk, B., Popiołek, A. K., Stachowicz-Karpińska, A., Gołota, S., Bieliński, M. K., & Borkowska, A. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200501 · Cited by 31 · see citing works
“However, similar results for deferred memory function have been reported in PC patients treated with radiotherapy, with no major deficits being detected in terms of attention or executive function.(42) Research in patients”
Result
Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer
Feng, L., Fuss, T., Dickinson, K. A., Ross, A., & Saligan, L. N. (2019) · Oncology · doi:10.1159/000494620 · Cited by 29 · see citing works
Self-citation
The Potential Effects of Radiation on the Gut-Brain Axis
Jones, C. B., Davis, C. M., & Sfanos, K. S. (2020) · Radiation Research · doi:10.1667/rr15493.1 · Cited by 27 · see citing works
“A prostate cancer study showed that cancer-related fatigue during radiotherapy was often associated with cognitive impairment, and the authors posited that there may be specific cognitive domains associated with fatigue and cognitive impairment during external beam radiation therapy (EBRT) (79).”
Background
Prevalence and associated factors of chemotherapy‐related cognitive impairment in older breast cancer survivors
Zhou, X., Zhang, X., Zhong, T., Zhou, M., Gao, L., & Chen, L. (2023) · Journal of Advanced Nursing · doi:10.1111/jan.15842 · Cited by 24 · see citing works
Fatigue and cognitive functions in epilepsy: A review of the literature
Lagogianni, C., Gatzonis, S. D., & Patrikelis, P. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107541 · Cited by 20 · see citing works
Brain-Derived Neurotrophic Factor Polymorphism Val66Met Protects Against Cancer-Related Fatigue
Feng, L., Juneau, P. L., Regan, J. M., Liwang, J. K., Alshawi, S. A., Wang, A. Y., & Saligan, L. N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00990-4 · Cited by 18 · see citing works
Self-citation
Risk of Cognitive Effects in Comorbid Patients With Prostate Cancer Treated With Androgen Receptor Inhibitors
Morgans, A. K., Renzulli, J., Olivier, K. M., & Shore, N. D. (2021) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2021.03.014 · Cited by 18 · see citing works
Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial
Mundell, N. L., Owen, P. J., Via, J. D., Macpherson, H., Daly, R. M., Livingston, P. M., Rantalainen, T., Foulkes, S., Millar, J. L., Murphy, D. G., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-060189 · Cited by 13 · see citing works
Cognition in patients treated with targeted therapy for chronic myeloid leukemia: a controlled comparison
Hyland, K. A., Eisel, S. L., Hoogland, A. I., Root, J. C., Bowles, K. E., James, B. W., Nelson, A. M., Booth‐Jones, M., Jacobsen, P. B., Ahles, T. A., et al. (2022) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2022.2148208 · Cited by 12 · see citing works
Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression
Wolff, B. S., Raheem, S. A., Alshawi, S. A., Regan, J. M., Feng, L., & Saligan, L. N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235566 · Cited by 7 · see citing works
Self-citation
Implementation Readiness and Initial Effects of a Brief Mindfulness Audio Intervention Compared With a Brief Music Control During Daily Radiation Therapy for Prostate Cancer: A Randomized Pilot Study.
Victorson, D., Mishra, K. K., Sauer, J., Langford, G., Maletich, C., Horowitz, B., Sauer, C., Sejpal, S. V., & Kalapurakal, J. (2024) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130241249140 · Cited by 5 · see citing works
Objective measurement of cancer-related fatigue
Beeler, D., O'Higgins, C. M., Brady, B., Walsh, D., & Reilly, R. B. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09764-4 · Cited by 5 · see citing works
“Research investigating brain mechanisms, like the default mode network [64] and neural connectivity patterns [65], may have a role in CRF.”
Development and validation of a risk prediction model for cognitive impairment in breast cancer patients
Zhang, X., Lu, J., Ding, Z., Qiao, Y., Li, X., Zhong, G., & Cui, H. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06278-x · Cited by 5 · see citing works
“In addition, cancer and treatment-related factors can cause patients to experience severe fatigue, which can negatively affect cognitive abilities such as executive function and recognition memory [54].”
Prostate cancer patients' experiences and preferences for web‐based physical activity applications: A qualitative meta‐synthesis
Zhang, R. Y., Sun, J., Zheng, X., Liu, M., Wang, H., Wang, X., & Guan, J. (2023) · Journal of Clinical Nursing · doi:10.1111/jocn.16819 · Cited by 4 · see citing works
Risk models of cancer-related cognitive complaints among early breast cancer survivors in the CANTO cohort
Presti, D., Meglio, A. D., Havas, J., Pagliuca, M., Cheaib, B., Martin, A., Gaudin, C., Jouannaud, C., Fournier, M., Kieffer, A., et al. (2025) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaf256 · Cited by 3 · see citing works
Characterization of cancer survivors clustered by subjective and objective cognitive function scores
Goto, T., Saligan, L. N., Juneau, P. L., Gonsalves, S. G., Rio, C. J., Graves, L. Y., & Ah, D. M. V. (2024) · Cancer Medicine · doi:10.1002/cam4.7255 · Cited by 2 · see citing works
“47 Similar relationships between cognitive function and fatigue were also observed in various cancer types, such as localized colorectal cancer and breast cancer.”
BackgroundSelf-citation
Effect Of Pranayama on Reducing the Level of Fatigue During External Radiation Therapy Among the Patients in A Cancer Hospital of Guwahati, Assam India
Kaur, R., Bordoloi, B., & Baruah, J. S. (2023) · National Journal of Community Medicine · doi:10.55489/njcm.140320232463 · Cited by 2 · see citing works
Feasibility and safety of physical exercise in men with prostate cancer receiving androgen deprivation therapy and radiotherapy: a study protocol
Bressi, B., Iotti, C., Cagliari, M., Cavuto, S., Fugazzaro, S., & Costi, S. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-048854 · Cited by 2 · see citing works
Feasibility and initial assessment of a holistic neuropsychological day program for vocational rehabilitation following non-central nervous system cancer
Bloch, A., Sharoni, L., Shany‐Ur, T., Maril, S., & Margalit, D. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1415038 · Cited by 1 · see citing works
“Depression, anxiety, and chronic fatigue are particularly common (Feng et al., 2018), as is fear of cancer recurrence (FCR), which has been reported in 78% of survivors and patients (Luigjes-Huizer et al., 2022).”
Cancer-related Fatigue and Associated Factors in Breast Cancer: Special Emphasis on Cognition
Kaya, G., & Tuğral, A. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02291-1
Non‐Medical Interventions to Improve Functional Outcomes for Men Undergoing Radiotherapy for Prostate Cancer: A Systematic Review
Hung, B., Tiruye, T. Y., Morias, S., & Beckmann, K. (2026) · European Journal of Cancer Care · doi:10.1155/ecc/1941313

Cognitive and motor aspects of cancer‐related fatigue
Feng, L., Regan, J. M., Shrader, J. A., Liwang, J. K., Ross, A., Maharaj, S. K., & Saligan, L. N. (2019) · Cancer Medicine · doi:10.1002/cam4.2490 · Cited by 42 · see citing works
Self-citation
Fatigue in prostate cancer patients treated with external beam radiotherapy: A prospective 5-year long-term patient-reported evaluation
Fransson, P. (2010) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.77076 · Cited by 26 · see citing works
(P109) Factors Associated With Increase in Fatigue in Prostate Cancer (PC) Patients Undergoing External Beam Radiation Therapy (EBRT)
Chao, H., Doucette, A. G., Raizen, D. M., & Vapiwala, N. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.02.205 · Cited by 2 · see citing works
Evaluating the Effects of Fatigue-Induction on Mice’s Cognitive Behavior
Bruinsma, S., Yang, A., Lopez-Tenorio, C., Lai, C., Lai, K., & Narayanan, S. (2021) · eScholarship (California Digital Library)
Factors Associated With Increase in Fatigue in Prostate Cancer Patients Undergoing External Beam Radiation Therapy
Chao, H. H., Doucette, A. G., Raizen, D. M., & Vapiwala, N. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.06.1877

Authors: Feng, L. R., Espina, A., & Saligan, L. N.
Affiliations: National Institutes of Health (US)
ORCID: Feng, Li Rebekah
Saligan, Leorey N.
Venue: Oncology
Publisher: S. Karger AG
Published: 2018
Volume: 94
Issue: 6
Pages: 363-372
ISSN: 0030-2414 (ISSN-L)
1423-0232
DOI: 10.1159/000487081
PMC: PMC6067654
OpenAlex: W2794380104
Cited by: 24
References: 57
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 4
FWCI: 1.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Oncology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health
National Institute of Nursing Research
NHLBI Division of Intramural Research
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: cancer-related fatigue, cognitive impairment, external beam radiotherapy, prostate cancer, executive function, recognition memory, route finding, mild cognitive impairment
MeSH terms: Aged, Fatigue, Humans, Male, Prostatic Neoplasms, Executive Function, Self Report, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of Fatigue Intensification with Cognitive Impairment during Radiation Therapy for Prostate Cancer

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks