Cited by 204Advanced Glycation End Products researchRetinal Diseases and TreatmentsAldose Reductase and Taurine

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Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy

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Xu, Jing, Chen, Lin-Jiang, Yu, Jian, Wang, Han-Jing, Zhang, Fan, Liu, Qiong, Wu, Jing·2018·Cellular Physiology and Biochemistry

DOI 10.1159/000491897

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Abstract

Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal barrier (BRB), the end result of all these events is damage to the neural and vascular components of the retina. Elucidation of AGE-induced mechanisms will help in the understanding of the complex cellular and molecular pathogenesis associated with DR. Novel anti-AGEs agents or AGE crosslink “breakers” are being investigated, it is hoped that in next few years, some of these promising therapies will be successfully applied in clinical context, aiming to reduce the major economical and medical burden caused by DR.

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Authors: Xu, J., Chen, L.-J., Yu, J., Wang, H.-J., Zhang, F., Liu, Q., & Wu, J.
Affiliations: Nanfang Hospital (CN)
ORCID: Xu, Jing
Yu, Jian
Zhang, Fan
Liu, Qiong
Wu, Jing
Venue: Cellular Physiology and Biochemistry
Publisher: S. Karger AG
Published: 2018
Volume: 48
Issue: 2
Pages: 705-717
ISSN: 1015-8987 (ISSN-L)
1421-9778
DOI: 10.1159/000491897
OpenAlex: W2883415922
Cited by: 204
References: 73
Citations by year: 2026: 13 · 2025: 28 · 2024: 21 · 2023: 28 · 2022: 35 · 2021: 33 · 2020: 31 · 2019: 14 · 2018: 1
FWCI: 15.34
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
creativecommons.org/licenses/by-nc-nd/4.0/ (tdm)
Locations: Cellular Physiology and Biochemistry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Science and Technology Planning Project of Guangdong Province
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: diabetic retinopathy, advanced glycation end products, receptor for advanced glycation end products, hyperglycemia, extracellular matrix cross-linking, vascular stiffness, endothelial dysfunction, pericyte apoptosis, angiogenesis, vascular inflammation, blood-retinal barrier breakdown, retinal microvascular complications
MeSH terms: Receptor for Advanced Glycation End Products, Blood-Retinal Barrier, Diabetic Retinopathy, Humans, Glycation End Products, Advanced, Reactive Oxygen Species, Vascular Endothelial Growth Factor A, Endoplasmic Reticulum Stress, Tight Junction Proteins

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Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy

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