Analysis of Oral Microbiota Revealed High Abundance of Prevotella Intermedia in Gout Patients
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Background/Aims: Microbes reside in a number of body sites, including the oral cavity, and are associated with the progression of many systemic diseases. In this study, we aimed to investigate the effects of gout and hyperuricemia (HUA) on the composition of oral microbiomes. Methods: Analysis of the oral microbiota from 12 gout patients, 11 HUA patients, and 19 healthy control subjects was performed using a deep sequencing approach, and validation of significant changes in Prevotella intermedia and Serratia marcescens in new patient cohorts was performed using quantitative PCR (qPCR). Results: Our analysis indicated that both gout and HUA significantly altered the composition of the oral microbiome in patients. Patients with gout or HUA had significantly greater levels of salivary Prevotella intermedia but significantly lower levels of Serratia marcescens than healthy control subjects. Conclusion: We demonstrated the association between the oral microbiome and gout and HUA for the first time. In particular, 16S sequencing and qPCR analysis revealed significantly higher levels of oral Prevotella intermedia in gout/HUA patients, which suggests that these patients might be at risk for the development of periodontitis.
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Based on reported target strain abundance in saliva (<10^7 cells/mL for each target species) and average saliva volume, the total amount of postbiotic cells required for efficient coaggregation was estimated to be 10^9 bacterial cells/g of product.
“Based on the reported target strain abundance in saliva (<107 cells/mL saliva for each of the target species) [43–46] and the average saliva volume in the mouth under stimulated conditions [47,48], we estimated that the total amount of postbiotic cells required for efficient coaggregation would be 109 bacterial cells/g of product.”
From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [44]
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Coaggregation of oral pathogens by postbiotic lactobacilli
Golletz, P., Jensen, S. D., Collignon, M., Hall, C., Khamas, A. B., Møllebjerg, A., Schlafer, S., Meyer, R. L., & Tykwinska, K. (2025) · Journal of oral microbiology · doi:10.1080/20002297.2025.2508483 · Cited by 10 · see citing works
- Authors
- Liu, J., Cui, L., Yan, X., Zhao, X., Cheng, J., Zhou, L., Gao, J., Cao, Z., Ye, X., & Hu, S.
- Affiliations
- Changzhou No.2 People's Hospital (CN)
- University of California, Los Angeles (US)
- Southern Medical University (CN)
- ORCID
- Venue
- Cellular Physiology and Biochemistry
- Publisher
- S. Karger AG
- Published
- 2018
- Volume
- 49
- Issue
- 5
- Pages
- 1804-1812
- ISSN
- 1015-8987 (ISSN-L)
- 1421-9778
- OpenAlex
- W2890625506
- Cited by
- 45
- References
- 24
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 13 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 2
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cellular Physiology and Biochemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- gout, hyperuricemia, oral microbiota, Prevotella intermedia, Serratia marcescens, salivary microbiota, periodontitis risk, dysbiosis
- MeSH terms
- Adult, Aged, Female, Gout, Humans, Male, Middle Aged, Mouth, RNA, Ribosomal, 16S, Serratia marcescens, Case-Control Studies, Prevotella intermedia, Hyperuricemia, Microbiota
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