The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Evolution and Future of Growth Plate Therapeutics
Abstract
Background: Longitudinal bone growth is regulated by multiple endocrine signals (e.g., growth hormone, insulin-like growth factor I, estrogen, and androgen) and local factors (e.g., fibroblast growth factors and their receptors and the C-natriuretic peptide/natriuretic peptide receptor-B pathway). Summary: Abnormalities in both endocrine and local regulation of growth plate physiology cause many disorders of human skeletal growth. Knowledge of these pathways creates therapeutic potential for sustaining or even augmenting linear growth. Key Message: During the past 4 decades, advances in understanding growth plate physiology have been accompanied by development and implementation of growth-promoting treatments that have progressed in both efficacy and specificity of action. This paper reviews the history and continuing evolution of growth plate therapeutics.
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“During puberty, increases in circulating GH, IGF-I, and sex hormones lead to accelerated height velocity but also to estrogen-induced epiphyseal fusion.93,103,104”
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“Some studies have suggested that adult height may also be achieved by increasing the GH dose during puberty (to mimic the pubertal increase in GH secretion observed in individuals who are GH sufficient) or by delaying puberty using gonadotropin-releasing hormone analogs.103,104,106”
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Hero, M., Norjavaara, E., & Dunkel, L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1392 · Cited by 198
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Cited by
Wexler, T. L., Reifschneider, K., Backeljauw, P., Cárdenas, J. F., Hoffman, A. R., Miller, B. S., & Yuen, K. C. J. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0384 · Cited by 19
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Metadata
- Authors
- Allen, D. B., Merchant, N., Miller, B. S., & Backeljauw, P. F.
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2021
- Volume
- 94
- Issue
- 9-10
- Pages
- 319-332
- ISSN
- 1663-2818
- 1663-2826
- Cited by
- 31
- References
- 2
- Language
- en
- Licence
- www.karger.com/Services/SiteLicenses (vor)
- www.karger.com/Services/SiteLicenses (tdm)
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- Allen, D. B., Merchant, N., Miller, B. S., & Backeljauw, P. F. (2021). Evolution and Future of Growth Plate Therapeutics. Hormone Research in Paediatrics. https://doi.org/10.1159/000520812
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
