The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TLR10: An intriguing Toll-like receptor with many unanswered questions
Abstract
Background: Toll-like receptors (TLRs) are one of the first pattern recognition receptors (PRRs) found in the innate immune system. The TLR family has 12 members (TLR1-TLR9, TLR11-TLR13) in mice and 10 members (TLR1-TLR10) in humans, with TLR10 being the latest identified. Summary: Considerable research has been performed on TLRs, however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, its function and signalling pathway are yet to be determined. Key messages: This review gives an insight into recent findings on TLR10 pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor.
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Cites
Assembly and localization of Toll-like receptor signalling complexes
Gay, N. J., Symmons, M. F., Gangloff, M., & Bryant, C. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3713 · Cited by 832
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
Soucie, E. L., Weng, Z., Geirsdóttir, L., Molawi, K., Maurizio, J., Fenouil, R., Mossadegh-Keller, N., Gimenez, G., VanHille, L., Beniazza, M., et al. (2016) · Science · doi:10.1126/science.aad5510 · Cited by 263
Dannemann, M., Andrés, A. M., & Kelso, J. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.11.015 · Cited by 249
Metadata
- Authors
- Rodrigues, C. R., Balachandran, Y., Aulakh, G. K., & Singh, B.
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2024-01-19
- ISSN
- 1662-811X
- 1662-8128
- Cited by
- 4
- References
- 3
- Language
- en
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